Method: A multicenter study was carried out in consecutive patients with FM (1990 FMACRCC) and concurrent healthy controls matched by sex and age (± 3 years). The proposed site, the accepted ACR sites (pairs) and control sites (pairs) biceps, quadriceps, and external aspect of the foot were evaluated by digital pressure averaging 4 kg/cm2 exerted by a previous trained rheumatologist. Sensitivity and specificity of the new, the ACR accepted and the control tender points were compared by unpaired t-test and the McNemar test.
Results: : There was a total of 55 FM female patients with an average age of 47 ± 9.8 years. Healthy controls comprised 48 females with a similar age distribution (44 ± 11 years). The new plantar site was tender in 48/55 FM patients (87%) vs. 2/48 controls (4%) giving a sensitivity of 87%, specificity of 96%, positive LR of 20.9 (CI 95%=6.2-76.1) and negative LR of 0.13 (CI 95%=0.06-0.25). Some of the ACR tender sites had lower sensitivity and specificity than the new plantar site i.e, occiput was tender in 15% of controls (sensitivity 71%, specificity 85%), trapezius was positive in 33% of controls (sensitivity 87%, specificity 67%) and low cervical was positive in 35% of controls (sensitivity 78%, specificity 65%).Control sites were negative in 34/48 (71%) FM patients with the plantar site positive. The plantar site had good concordance in FM patients with tender sites such as the lateral epicondyle (73%) and the occiput (65%)
Conclusion: Our findings indicate that a tender site located infero-medially in the distal third of the longitudinal plantar arch has a high sensitivity and specificity in patients with FM as defined by the FMACRCC. Furthermore, it had a greater specificity than cephalad sites such as occiput, trapezium and low cervical sites. Further investigations on this novel site appear warranted.
Disclosure: A. Spindler, None; W. Spindler, None; V. Bellomio, None; A. Berman, None; E. Lucero, None; H. Berman, None; R. Sueldo, None; L. Gonzalez, None; M. V. Gandur, None; M. Guardia, None; A. L. Barbaglia, None; M. Santana, None; C. Waimann, None; K. Kyrmair, None; R. Chaparro del Moral, None; O. Rillo, None; J. Moreno, None.
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