Method: We reported the main characteristics, treatment and long-term outcome of 101 (12.3%) patients with arterial lesions among a cohort of 820 BD patients. Factors that affect prognosis were assessed by multivariate analysis.
Result: There was 93 (91.2%) male with a median age at diagnosis of BD of 33 [27-41] years. Arterial lesions included aneurysms (47.3%), occlusions (36.5%), stenosis (13.5%) and aortitis (2.7%). Lesions mainly involved aorta (n=25), femoral (n=23) and pulmonary (n=21) arteries. Patients with arterial lesions were more frequently of male gender (91.2% versus 62.4%, respectively, p=0.017) and had higher rate of venous involvement (80.4% versus 29.8%, respectively, p<0.001) compared to those without arterial manifestations. Thirty nine (38.6%) patients achieved a complete remission. In multivariate analysis, the presence of venous involvement [odds ratio (95% CI), 0.29 (0.08-1.11)] and arterial occlusive lesions [0.13 (0.01-1.25)] were negatively associated with complete remission. The use of immunosuppressants [3.38 (0.87-13.23)] was associated with the occurrence of complete remission. The 20-years survival rate was signicantly lower in BD patients with arterial involvement compared to those without arterial lesions (73% vs 89%, p<0.0001, respectively).
Conclusion: In conclusion, the long-term outcome of arterial lesions in BD is poor, especially in case of occlusive lesions and associated venous involvement. The use of immunosuppressants improved the prognosis.
Disclosure: D. Saadoun, None; B. Asli, None; B. Wechsler, None; H. Houman, None; G. Geri, None; J. C. Piette, None; Z. Amoura, None; M. Resche Rigon, None; P. Cacoub, None.