Mechanisms of Lymphoma Development in Systemic Autoimmune Disease

Session Type: ACR Basic Science Symposia
Tuesday, November 8, 2011: 2:30 PM-4:00 PM
W181a (McCormick Place West)
Research  SessionSelect

Session Overview:
Several systemic autoimmune diseases, including Sjögren’s syndrome and rheumatoid arthritis, are associated with a substantially increased risk of lymphoma. Case control and other population based studies have sought to identify common mechanisms and pathways underlying autoimmunity and lymphoma. More recently, molecular and other basic research has provided clues about underlying pathogenic mechanisms. Increased knowledge in this area has the potential to reveal shared etiologic factors that may be relevant to prognostic and therapeutic approaches to systemic autoimmunity.

Upon completion of this session, participants should be able to:

  • summarize the specific autoimmune diseases that have been demonstrated to be associated with an increased risk of lymphoma development, including the specific autoimmune diseases and lymphoma types, the strength of those associations, and limitations of the studies performed to date
  • discuss the disease features that characterize Sjögren’s syndrome patients of greatest risk of lymphoma development and the etiologic mechanisms implicated by those associations
  • describe the genes and pathways that are implicated in the development of both autoimmune disease and lymphoma based on their roles in inhibiting uncontrolled B-cell growth

Moderators: Corinne Miceli-Richard, MD, PhD, Hopital Bicêtre and Lindsey A. Criswell, MD, MPH, University of California San Francisco
Talks:
2:30 PM
Autoimmunity and Lymphomagenesis
Lynn Goldin, National Institutes of Health, National Cancer Institute, Bethesda, MD
2:55 PM
Mechanisms of Non-Hodgkin's Lymphoma in Sjögren's Syndrome
Xavier Mariette, Université Paris-Sud, Le Kremlin Bicetre, France
3:20 PM
Pathogenic Mechanisms of Lymphoma Development in Autoimmune Disease
Rafael Casellas, National Institutes of Health, Bethesda, MD
See more of: ACR Basic Science Symposia

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