Osteoarthritis: A Disease of the Joint as an Organ

Session Type: ACR Basic Science Symposia
Tuesday, November 8, 2011: 4:30 PM-6:00 PM
W196b (McCormick Place West)
Research  SessionSelect

Session Overview:
Much of the past research in osteoarthritis has focused on the articular cartilage, while it is clear that osteoarthritis involves the entire joint as an organ. More recent studies have examined the role of the synovium and the subchondral bone as well as on how developmental changes in the joint might contribute to development of osteoarthritis later in life. A better understanding of these processes will lead to new therapeutic targets needed for management of osteoarthritis.

Upon completion of this session, participants should be able to:

  • recognize osteoarthritis as a condition of the entire joint as an organ
  • identify developmental processes within the joint that may contribute to the development of osteoarthritis
  • define the synovial changes that occur in osteoarthritis and discuss how synovitis may contribute to disease progression
  • relate the changes in the subchondral bone to joint tissue changes in osteoarthritis

Moderators: Richard F. Loeser, MD, Wake Forest University and Carla R. Scanzello, MD, PhD, Rush University Medical Center
4:30 PM
How Understanding Joint Development Can Contribute to a New Understanding of Osteoarthritis
Maurizio Pacifici, Children's Hospital of Philadelphia, Philadelphia, PA
4:55 PM
The Role of Synovial Inflammation in Osteoarthritis
Wim B. Van Den Berg, Radboud Univ Nijmegen Med Centre, Nijmegen, Netherlands
5:20 PM
The Subchondral Bone and Osteoarthritis: Not Just Hard Tissue
Harrie Weinans, Erasmus MC, Rotterdam, Netherlands
See more of: ACR Basic Science Symposia

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