Next-Generation Sequencing Applied to Rheumatic Diseases

Session Type: ACR Basic Science Symposia
Tuesday, November 8, 2011: 2:30 PM-4:00 PM
W470b (McCormick Place West)
Research  SessionSelect

Session Overview:
Advances in genomic technology now make it possible to sequence the entire human genome at an affordable cost.  As a consequence, next-generation sequencing is being used as a tool to understand the genetic basis of rheumatic diseases.  The whole genome is being sequenced to search for rare variants that contribute to disease risk.  Regions of the T-cell receptor and immunoglobulin locus are being sequenced to search for somatic rearrangements that are specific to patients. Ribonucleic acid is being sequenced from affected tissues as a novel way to identify unique patterns of expression.

Upon completion of this session, participants should be able to:

  • define the role of next-generation sequencing in scientific discovery
  • recognize the difference between common and rare variants
  • describe the role of T-cell receptor and immunoglobulin locus in rheumatoid arthritis pathogenesis

Moderators: Robert M. Plenge, MD, PhD, Brigham and Women's Hospital and Paul L. Klarenbeek, MD, MSc, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital
2:30 PM
Large-Scale Sequencing in Patients with Rheumatoid Arthritis
Peter K. Gregersen, Feinstein Institute Medical Reschearch, Manhasset, NY
2:55 PM
Role of T-cell Receptor Sequencing in Rheumatic Diseases
Niek De Vries, AMC / University of Amsterdam F4-105, Amsterdam, Netherlands
3:20 PM
Sequencing of Immunoglobulin Repertoires in Rheumatoid Arthritis
William Robinson, Stanford Univ School of Med, Stanford, CA
See more of: ACR Basic Science Symposia

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