Towards Prevention of Atherosclerosis Progression in Rheumatoid Arthritis: Insights into the Relationship between Inflammation and Cardiovascular Disease

Session Type: ACR Basic Science Symposia
Tuesday, November 8, 2011: 11:00 AM-12:30 PM
W375c (McCormick Place West)
Research  SessionSelect

Session Overview:
Rheumatoid arthritis is a prototypical immune-mediated inflammatory disease that is characterized by increased cardiovascular morbidity and mortality, independent of the traditional risk factors for cardiovascular disease. Efforts to understand how the ‘chronic inflammatory state’ contributes to atherosclerotic disease, as well as to understand the molecular pathogenesis of atherosclerotic plaques, are leading to new targets for therapy.

Upon completion of this session, participants should be able to:

  • review the data on the molecular pathogenesis of accelerated atherogenesis in rheumatoid arthritis and other immune-mediated inflammatory disorders
  • identify the primary cellular and molecular pathways that are targeted by local and systemic inflammatory responses
  • discuss the potential targets for therapy that may reduce the cardiovascular burden as well as disease activity in rheumatoid arthritis

Moderators: Joćo E. Fonseca, MD, PhD, Lisbon Academic Medical Center, on behalf of Rheumatic Diseases Portuguese Register ( and Radjesh J. Bisoendial, MD, PhD, Academic Medical Center/ University of Amsterdam
11:00 AM
How Inflammation Impacts Endothelial Function as Primary Target for Cardiovascular Diseases
Kees Hovingh, Academic Medical Center at the University of Amsterdam , Amsterdam, Netherlands
11:25 AM
Macrophage Death and Defective Apoptotic Cell Clearance in Advanced Atherosclerotic Plaque Progression
Bart Staels, Universite de Lille II, Lille, France
11:50 AM
The Interacting Roles of Reverse Cholesterol Transport and Inflammation and Their Relationship to Atherosclerosis
Daniel J. Rader, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
See more of: ACR Basic Science Symposia

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