Mechanisms and origins of pain in arthritis are still poorly understood. Inflammation plays a central role in the manner that the nervous system responds to injury, one of which the effects is pain. Recent research has recognized the central role of cytokines, chemokines and their receptors in chronic pain generation.
Upon completion of this session, participants should be able to:
- describe how the expression of inflammatory cytokines in association with tissue damage triggers diverse changes in the behavior of sensory neurons in the context of chronic pain syndromes
- summarize the actions of inflammatory cytokines synthesized by dorsal root ganglia neurons, associated glial cells, as well as by astrocytes and microglia in the spinal cord
- translate the knowledge of mechanisms of chronic pain generation into novel analgesic targets
|Moderator:||Anne-Marie Malfait, MD, PhD, Rush University Medical Center|
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