Nearly a century after the significance of the human complement system was recognized, we have come to realize that its functions extend far beyond the elimination of microbes. Complement acts as a rapid and efficient immune surveillance system that has distinct effects on healthy and altered host cells and foreign intruders. By eliminating cellular debris and infectious microbes, orchestrating immune responses and sending danger signals, complement contributes substantially to homeostasis, but it can also take action against healthy cells if not properly controlled. This review describes our updated view of the function, structure and dynamics of the complement network, highlights its interconnection with immunity at large and with other endogenous pathways, and illustrates its multiple roles in homeostasis and disease. In addition, it will discuss promising points-of-intervention within the complement cascade and provide an overview over current treatment strategies to treat a rapidly growing number of diseases.
Upon completion of this session, participants should be able to:
- appreciate basic principles of complement biology
- define how particular complement factors can enhance immune defenses from infection, or contribute to host homeostasis
- review emerging data on unexpected roles of complement, and aberrant pathways in the immune pathogenesis of inflammatory diseases
|Moderator:||Gregg J. Silverman, MD, NYU School of Medicine|
To see other sessions for this day, use the date buttons to the left.