Rheumatologist understanding of autoimmune pathogenesis is rapidly advancing. There have been rapid advances in how T cell selection occurs to maintain a healthy immune system and how certain genetic defects can result in loss of tolerance. The maintenance of immunologic self-tolerance requires the coordination of multiple complementary systems. Studies of the autoimmune regulator gene have revealed that autoimmune regulator promotes self-tolerance partly by inducing the transcription of a wide array of tissue-specific antigens, particularly in the thymus. The importance of autoimmune regulator is highlighted by the fact that patients and mice defective in autoimmune regulator expression develop a multi-organ autoimmune syndrome.
Upon completion of this session, participants should be able to:
- describe basic principles of T cell biology and selection of antigen specific responses
- evaluate how expression of self antigens in the thymus is controlled and under the regulation of certain genetic elements
- cite how impaired expression of genes such as autoimmune regulator can result in organ specific autoimmunity, and how this has changed our understanding of autoimmune disease pathogenesis
|Moderator:||Gregg J. Silverman, MD, NYU School of Medicine|
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