Spondylarthropathies have a combined prevalence of between one and two percent and frequently result in chronic pain and functional impairment. Despite the discovery of the strong association of this cluster of diseases with the HLA B27 allele, an in-depth understanding of pathogenesis has remained elusive. While anti-TNF therapies have proven to be effective, approximately 40-50 percent of patients are inadequate responders to these agents, which underscores the need to improve our understanding of disease mechanisms in order to develop more effective therapies.
Upon completion of this session, participants should be able to:
- outline the impact of tumor necrosis factor inhibition on the progression of vertebral changes observed on magnetic resonance imaging in antiphospholipid syndrome patients
- discuss new treatment approaches to the prevention of pathologic new bone formation in antiphospholipid syndrome
- review the data on the efficacy and safety of methotrexate in prostate-specific antigen
- assess if methotrexate is a disease-modifying anti-rheumatic drugs in prostate-specific antigen
- state the strains of chlamydia associated with reactive arthritis
- summarize the recent evidence regarding the efficacy and safety of prolonged antibiotic therapy for reactive arthritis induced by chlamydia
|Moderator:||M. Elaine Husni, MD, MPH, Cleveland Clinic Foundation|
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