The interplay of the nervous, endocrine, and immune systems is recognized to be involved in pathophysiology of chronic inflammatory diseases. In addition, recent review articles highlight the importance of energy regulation in chronic inflammatory diseases as an interesting and important aspect. In this session we discuss energy regulation as having a top hierarchical position of homeostatic regulation in chronic inflammatory diseases. Combining energy regulation and neuroendocrine immune interplay in the context of chronic inflammatory diseases leads to a new comprehension of many clinical symptoms and laboratory abnormalities presently described as independent phenomena.
Upon completion of this session, participants should be able to:
- recognize the important role of energy regulation in the neuroendocrine immune interplay
- discuss how nervous, endocrine, immune and bioenergetic systems are involved in the pathophysiology of chronic inflammatory diseases
- discuss the involvement of macrophage migration inhibitory factor in the regulation of cellular energy metabolism
- review the bioenergetic aspects of insulin resistance in chronic inflammatory diseases
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