Macrophage Activation Syndrome

Session Type: ACR Study Groups
Tuesday, November 8, 2011: 1:00 PM-2:00 PM
W192b (McCormick Place West)

Session Overview:
Macrophage activation syndrome is an often lethal hemophagocytic syndrome associated with a variety of pediatric and adult infectious, oncologic, and rheumatic conditions. Early recognition of macrophage activation syndrome and institution of aggressive immunosuppressive therapy are keys to optimizing survival. This requires knowledge of the settings in which macrophage activation syndrome can occur, as well as tools/criteria for identifying various forms of secondary macrophage activation syndrome. Recently, novel biological therapies directed at shutting down the cytokine storm are being used to treat secondary forms of macrophage activation syndrome. The outcomes of these therapies appear promising relative to traditional etoposide based protocols used for primary/familial forms of hemophagocytic syndromes.

Upon completion of this session, participants should be able to:

  • identify the most common rheumatic disorders associated with macrophage activation syndrome
  • discuss the diagnostic criteria for macrophage activation syndrome for secondary forms of macrophage activation syndrome
  • distinguish the HLH-2004 protocol from biologic therapies for secondary macrophage activation syndrome
  • articulate the survival rates for current therapies for treating secondary macrophage activation syndrome

Talks:
1:00 PM
The Scope of Secondary Macrophage Activation Syndrome
Randy Q. Cron, Univ of Alabama-Birmingham, Birmingham, AL
1:15 PM
Developing Diagnostic Criteria for MAS in Patients with Secondary MAS
Angelo Ravelli, University of Genova, Genoa, Italy
1:35 PM
Treatment for Hemophagocytic Lymphohistiocytosis, An Historic Perspective
Jan-Inge Henter, Karolinska Institutet, Stockholm, Sweden
1:55 PM
Treatment Outcomes for Secondary MAS in the Era of Biologic Therapies
Paivi Miettunnen, University of Calgary, Calgary, AB
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