Psoriatic Arthritis is a unique condition which involves multiple organ systems (skin, joint, bone, tendons) in the setting of chronic immune activation. Psoriatic Arthritis may result in severe bone destruction (arthritis multilans) and, paradoxically, extensive new bone formation can coexist, even in the same digit. Therapeutic targets for inflammation may not impact on these bony features- the paradigm of early treatment to prevent bony changes has not yet been fully tested in this disease. The discipline of ostoimmunology promises to give new insights into the mechanisms underlying these changes, with the promise of new treatment targets to follow.
Upon completion of this session, participants should be able to:
- describe the new advances in the field of steoimmunology
- identify these changes to clinical and radiological appearance seen in psoriatic arthritis
- recognize how animal models can help our understanding of these mechanisms and how they may lead to new treatments
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