Systemic Sclerosis Fibrosing Syndromes and Raynaud's - Pathogenesis, Animal Models and Genetics I

Session Type: ACR Abstract Submissions
Tuesday, November 8, 2011: 4:30 PM-6:00 PM
W183c (McCormick Place West)
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Moderators: Marco Matucci-Cerinic, Univ Florence and Robert Lafyatis, MD, E5 Arthritis Ctr-Boston University Sch Medicine
Papers:
4:30 PM
Transforming Growth Factor Beta Mediated Activation of Canonical Wnt Signaling Is Crucial for the Development of Fibrosis In Systemic Sclerosis
Alfiya Akhmetshina1, Katrin Palumbo2, Christina Bergmann2, Paulius Venalis2, Clara Dees2, Pawel Zerr2, Angelika Horn2, Christian Beyer3, Jochen Zwerina2, Ormond A. MacDougald4, Oliver Distler5, Georg Schett2 and Jorg HW Distler2, 1Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 2Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 3University of Erlangen-Nuremberg, Erlangen, Germany, 4Department of Pediatrics, University of Erlangen-Nuremberg, Erlangen, Germany, 5University Hospital Zurich, Zurich, Switzerland
4:45 PM
Anti-Fibrotic Effects of Microrna-145 in Systemic Sclerosis Via a Multi-Step Regulation of TGF-Beta/CTGF Signaling
Serena Vettori1, Matthias Brock1, Naoki Iwamoto1, Britta Maurer1, Astrid Jungel1, Renate E. Gay1, Maurizio Calcagni2, Gabriele Valentini3, Jorg HW Distler4, Steffen Gay1 and Oliver Distler1, 1Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, 2Division of Plastic Surgery and Hand Surgery, Zurich University Hospital, Zurich, Switzerland, 3Rheumatology Unit, Second University of Napoli, Napoli, Italy, 4Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany
5:00 PM
TLR4 Activation Enhances Fibrotic Responses Induced by TGF-▀: A Mechanism for Maintaining and Amplifying Fibrosis in Scleroderma
Swati Bhattacharyya1, Kathleen Kelly2, Denisa S. Melichian2, Kohtaro Ooka3, Carol A. Feghali-Bostwick4, Robert Lafyatis5, Timothy RD Radstake6 and John Varga1, 1Northwestern Univ Med School, Chicago, IL, 2Northwestern University, Chicago, IL, 3Northwestern University, 4University of Pittsburgh, Pittsburgh, PA, 5E5 Arthritis Ctr-Boston University Sch Medicine, Boston, MA, 6Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
5:15 PM
Tribbles Homolog 3ámediates Transforming Growth Factor betaádriven Dermal Fibrosis In Systemic Sclerosis
Michal Tomcik1, Katrin Palumbo2, JÚr˘me Avouac3, Angelika Horn2, Aisa Khodzhigorova2, Pawel Zerr2, Clara Dees2, Alfiya Akhmetshina4, Christian Beyer5, Radim Becvar1, Ladislav Senolt6, Oliver Distler7, Georg Schett2 and Jorg HW Distler2, 1Institute of Rheumatology, Department of Clinical and Experimental Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, 2Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 3Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France, 4Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 5University of Erlangen-Nuremberg, Erlangen, Germany, 6Institute of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, 7University Hospital Zurich, Zurich, Switzerland
5:30 PM
Inhibition of Glycogen Synthase Kinase 3β Induces Dermal Fibrosis by Activation of the Canonical Wnt Pathway
Christina Bergmann1, Alfiya Akhmetshina2, Clara Dees1, Katrin Palumbo1, Pawel Zerr1, Christian Beyer3, Jochen Zwerina1, Oliver Distler4, Georg Schett1 and Jorg HW Distler1, 1Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 2Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 3University of Erlangen-Nuremberg, Erlangen, Germany, 4University Hospital Zurich, Zurich, Switzerland
5:45 PM
The Nuclear Receptor CAR Mediates the Pro-Fibrotic Effects of TGF-β and Contributes to the Development of Experimental Dermal Fibrosis
Jerome Avouac1, Michal Tomcik2, Katrin Palumbo1, Pawel Zerr1, Clara Dees1, Alfiya Akhmetshina1, Christian Beyer1, Oliver Distler3, Georg Schett1, Yannick Allanore4 and Jorg HW Distler1, 1Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 2Institute of Rheumatology, Department of Clinical and Experimental Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, 3University Hospital Zurich, Zurich, Switzerland, 4Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France
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