Systemic Sclerosis Fibrosing Syndromes and Raynaud's - Pathogenesis, Animal Models and Genetics

Session Type: ACR Abstract Submissions
Tuesday, November 8, 2011: 9:00 AM-6:00 PM
Hall F2 - Poster Hall (McCormick Place West)
Papers:
Hypophosphatemia Is Associated with Nephrogenic Systemic Fibrosis: A Case-Control Study
Elana J. Bernstein1, Tamara Isakova2, Mary E. Sullivan3, Lori B. Chibnik4, Hasan Bazari3, Myles Wolf2 and Jonathan Kay5, 1Hospital for Special Surgery, New York, NY, 2University of Miami, Miami, FL, 3Massachusetts General Hospital, Boston, MA, 4Brigham & Women's Hospital, Boston, MA, 5University of Massachusetts Medical School, Worcester, MA
HLA-DRB5* 01:05 Is a Risk Factor for Systemic Sclerosis with Interstitial Lung Disease
Toshio Odani, Shinsuke Yasuda, Ayaka Kubota, Hisako Nakagawa, Yuichiro Fujieda, Kotaro Otomo, Masaru Kato, Tetsuya Horita, Tatsuya Atsumi and Takao Koike, Medicine II, Hokkaido University Graduate School of Medicine, Sapporo, Japan
A Transforming Growth Factor-β Receptor One Variant Is Associated with Constitutively Decreased Transforming Growth Factor-β Signaling and Risk for Systemic Sclerosis
Monique E. Hinchcliff1, Michael Pennison2, Jacquelyn Zimmerman2, Naresh Bellam2, Qinghua Zeng2, Chiang-Ching Huang1, Richard M. Pope1, Maureen Sadim1, Wendy Wolf3, Jeffrey C. Edberg4, Robert P. Kimberly2, Kui Zhang5, Jun Li5, Nengjun Yi5, Canadian Scleroderma Research Group (CSRG)6, Scleroderma Registry Investigators7, Maureen D. Mayes7, John Varga1 and Boris Pasche2, 1Northwestern Univ Med School, Chicago, IL, 2University of Alabama at Birmingham, Birmingham, AL, 3Harvard Medical School, Boston, MA, 4Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 5University of Alabama at Birmingham School of Public Health, Birmingham, AL, 6SMBD Jewish General Hospital, Montreal, QC, 7University of Texas Health Science Center at Houston, Houston, TX
Anti-AT(1)R and Anti-ET(A)R Autoantibodies in Systemic Sclerosis: Indication of Possible Involvement in Disease Pathology
Angela Kill1, Mike O. Becker2, Jeannine Guenther1, Harald Heidecke3, Duska Dragun2 and Gabriela Riemekasten1, 1Charité University Hospital, German Rheumatology Research Center, a Leibniz Institute, Berlin, Germany, 2Charité University Hospital, Berlin, Germany, 3CellTrend GmbH, Luckenwalde, Germany
Identification of Major Histocompatibility Complex Class II Alleles Associated with Systemic Sclerosis Through Imputation Strategy
Jose Ezequiel Martin1, International Scleroderma Group2, Timothy RD Radstake3, Filemon K. Tan4, Frank C. Arnett4, Maureen D. Mayes4, Paul de Bakker5, Bobby P.C. Koeleman6 and Javier Martin7, 1Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Armilla (Granada), Spain, 2Granada, Spain, 3Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 4University of Texas Health Science Center at Houston, Houston, TX, 5Brigham and Women's Hospital, Boston, MA, 6University Medical Center Utrecht, Utrecht, Netherlands, 7Instituto de Parasitologia y Biomedicina Lopez-Neyra (CSIC), Granada, Spain
FLOW Cytometric Analysis of CIRCULATING Microparticles In Systemic Sclerosis
Line V. Iversen, Statens Serum Institut, Copenhagen S, Denmark
A Peptide Derived From Endostatin Ameliorates Fibrosis Induced by TGF–β and Bleomycin in Multiple Pre-Clinical Models
Yukie Yamaguchi1, Takahisa Takihara2, Roger Chambers2, Adriana T. Larregina2 and Carol A. Feghali-Bostwick2, 1Yokohama City University Graduate School of Medicine, Yokohama, Japan, 2University of Pittsburgh, Pittsburgh, PA
Thymic Stromal Lymphopoietin (TSLP) Is Overexpressed in Scleroderma Skin and It Is Induced by TLR3 Activation in Dermal Fibroblasts
Alicia Usategui, Manuel J. Del Rey, Elena Izquierdo, Patricia E. Carreira, Pablo Ortiz and Jose L. Pablos, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain
Oxidation of Protein Tyrosine Phosphatase-1B Leads to Pronounced PDGFR Activation in Scleroderma Fibroblasts
Pei-Suen Tsou1, Adam J. Pinney1, Nadin N. Talia1, Sonsoles Piera-Velazquez2, Sergio A. Jimenez3, James R. Seibold4, Kristine Phillips1 and Alisa E. Koch5, 1University of Michigan Medical School, Ann Arbor, MI, 2Thomas Jefferson University, Philadelphia, PA, 3Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, PA, 4Scleroderma Research Consultants LLC, Avon, CT, 5Department of Veteran's Affairs and University of Michigan, Ann Arbor, MI
The Expression and Activities of Protein Tyrosine Phosphatases in Scleroderma Dermal Fibroblasts: Impact of Oxidative Stress on DEP-1 and SHP-2
Pei-Suen Tsou1, Adam J. Pinney1, Ann Kendzucky2, Sonsoles Piera-Velazquez3, Sergio A. Jimenez4, Kristine Phillips1 and Alisa E. Koch5, 1University of Michigan Medical School, Ann Arbor, MI, 2Grand Valley State University, MI, 3Thomas Jefferson University, Philadelphia, PA, 4Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, PA, 5Department of Veteran's Affairs and Unversity of Michigan, Ann Arbor, MI
Atorvastatin Attenuates Skin Fibrosis Through the PI3K Pathway
Yuko OTA, Yasushi Kawaguchi, Kae Takagi, Hisae Ichida, Takahisa Gono, Masanori Hanaoka and Hisashi Yamanaka, Tokyo Women's Medical University, Tokyo, Japan
The Role of Adiponectin in the Pathogenesis of Dermal Fibrosis in Systemic Sclerosis
Yoshihide Asano, Yuri Masui, Takafumi Kadono and Shinichi Sato, The University of Tokyo, Tokyo, Japan
Platelet Derived Growth Factor receptor inhibitor ARRY-768 Prevents Experimental Dermal Fibrosis and Induces Regression of Pre-Established Dermal Fibrosis
Michal Tomcik1, Nicole Reich2, Katrin Palumbo2, Pawel Zerr2, Jérôme Avouac3, Alfiya Akhmetshina2, Clara Dees2, Christian Beyer4, Radim Becvar1, Ladislav Senolt5, Oliver Distler6, Georg Schett2 and Jorg HW Distler2, 1Institute of Rheumatology, Department of Clinical and Experimental Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, 2Department of Internal Medicine 3 and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany, 3Paris Descartes University, Rheumatology A department, Cochin Hospital, Paris, France, 4University of Erlangen-Nuremberg, Erlangen, Germany, 5Institute of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, 6University Hospital Zurich, Zurich, Switzerland
Adenosine-Mediated Dermal Fibrosis and Fli-1 Expression in CD39 and CD73 Knockout Mice
Edwin SL Chan1, Gideon Smith1, Patricia Fernandez2, Hailing Liu1, Andrew G. Franks2, Maria Trojanowska3 and Bruce N. Cronstein4, 1New York University School of Medicine, New York, NY, 2New York University, New York, NY, 3Boston University, Boston, MA, 4New York Univ Medical Center, New York, NY
Enhanced IL-6 Trans-Signalling in Early dcSSc May Drive Fibrotic Response Via JAK2/STAT3 Signalling Pathways
Korsa Khan, UCL medical School, London, United Kingdom, Xu Shiwen, Royal Free Hospital, London, United Kingdom, David J. Abraham, Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, Christopher P. Denton, UCL Medical School, London, United Kingdom and Voon Ong, UCL Medical School, London, England
Estimation of Cellular States From SSc Gene Expression Reveals Heterogeneity of Pathway Expression
J. Matthew Mahoney and Michael L. Whitfield, Dartmouth Medical School, Hanover, NH
The Melanocortin System: A New and Important Actor on the Scene of Systemic Sclerosis
Grethe N. Andersen, Hospital of Vendsyssel/Ålborg University, Hjørring, Denmark, Olga Nagaeva, University of Umeå, Umeå, Sweden, Lucia Mincheva-Nilsson, University of Umeå, Sweden and Jarl E.S. Wikberg, Department of Pharmaceutical Pharmacology, Uppsala, Sweden
Identification of a Gene Expression Signature in Limited Cutaneous Systemic Sclerosis That Includes Several Vascular Genetic Factors
Cecilia B. Chighizola1, Pia Moinzadeh2, Korsa Khan3, Tammara A. Wood4, Pier Luigi Meroni5, David J. Abraham6, Michael L. Whitfield4, Voon Ong7 and Christopher P. Denton3, 1University Of Milan, Milan, Italy, 2Royal Free Hospital, Medical School, London, United Kingdom, 3UCL Medical School, London, United Kingdom, 4Dartmouth Medical School, Hanover, NH, 5University of Milan, Milan, Italy, 6Centre for Rheumatology and Connective Tissue Diseases, UCL Medical School, London, United Kingdom, 7UCL Medical School, London, England
A Novel Automated Longitudinal In Vivo Assessment of Bleomycin Induced Pulmonary Fibrosis in Mice Using In Vivo High Resolution Micro-Computed Tomography
Ellen De Langhe1, Greetje Vande Velde1, Jeroen Hostens2, Frank P. Luyten1, Ben Nemery1, Uwe Himmelreich1, Jeroen Vanoirbeek1 and Rik Lories1, 1KU Leuven, Leuven, Belgium, 2Skyscan
Gene-Gene Interactions In Interferon Pathway Gene-Mutations In European and American Scleroderma Cohorts
Pravitt R. Gourh1, Filemon K. Tan2, Blanca Rueda3, Frank C. Arnett2, Shervin Assassi2, John D. Reveille2, Timothy RD Radstake4, Maureen D. Mayes2, Javier Martin5 and Sandeep K. Agarwal2, 1UTHSC-Houston Medical School, Houston, TX, 2University of Texas Health Science Center at Houston, Houston, TX, 3Facultad de Ciencias de la Salud. Universidad de Granada, Granada, Spain, 4Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 5Instituto de Parasitologia y Biomedicina Lopez-Neyra (CSIC), Granada, Spain
Human Leukocyte Antigen Alleles in Juvenile Onset Systemic Sclerosis
Anne M. Stevens1, Maureen D. Mayes2, John D. Reveille2, Gretchen R. Henstorf3 and J. Lee Nelson4, 1University of Washington, Seattle, WA, 2University of Texas Health Science Center at Houston, Houston, TX, 3Seattle Children's Research Institute, Seattle, WA, 4Fred Hutchinson Cancer Rsch, Seattle, WA
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