Biology and Pathology of Bone and Joint: Inflammation and Osteoarthritis

Session Type: ACR Abstract Submissions
Tuesday, November 8, 2011: 9:00 AM-6:00 PM
Hall F2 - Poster Hall (McCormick Place West)
Papers:
Enhanced Expression of mRNA for Interleukin 6 and Tumor Necrosis Factor-Alpha In CD34+ Cells of the Bone Marrow In Osteoarthritis
Shunsei Hirohata, Kitasato Univ School of Med, Kanagawa, Japan, Tamiko Yanagida, Teikyo University School of Medicine, Tokyo, Japan, Tetsuya Tomita, Osaka University Med School, Suita Osaka, Japan and Hideki Yoshikawa, Osaka University Graduate School of Medicine, Osaka, Japan
Transcriptome Analysis Reveals a Robust Profile In Osteoarthritis Synovial Fibroblasts
Manuel J. Del Rey1, Alicia Usategui1, Elena Izquierdo1, Vanessa Miranda1, Juan D. Cañete2, Francisco J. Blanco Sr.3, Gabriel Criado1 and Jose L. Pablos1, 1Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, 2Hospital Clínic de Barcelona, IDIBAPS, Barcelona, Spain, 3INIBIC-CHUAC, La Coruna, Spain
Destabilization of the Medial Meniscus As a Model to Study the Relationship Between Joint Degeneration and Pain
Rachel E. Miller, Phuong Tran, Nayereh Ghoreishi-Haack, Rosalina Das and Anne-Marie Malfait, Rush University Medical Center, Chicago, IL
IL-1beta Inhibits TNF-Mediated Differentiation of Human Osteoclast Precursors Grown in Presence of Fibroblast-Like Synoviocytes
Bohdan P. Harvey, Farhan A. Syed and Zehra Kaymakcalan, Abbott Laboratories, Worcester, MA
Norepinephrine (NE) Affects Mesenchymal Stem Cell (MSCs) Chondrogenesis and Accordingly the Self-Regeneration Capacity of Cartilage
Zsuzsa Jenei-Lanzl, 1Laboratory of Experimental Rheumatology and Neuroendocrine Immunology, Department of Internal Medicine, University Hospital Regensburg, Regensburg, Germany, Peter Angele, Department of Trauma Surgery, University Hospital Regensburg, Germany, Regensburg, Germany and Rainer H. Straub, University Hospital Regensburg, Regensburg, Germany
Adiponectin Is Associated with Joint Inflammation and Cartilage Degradation in Osteoarthritis
Anna Koskinen1, Sami Juslin1, Katriina Vuolteenaho1, Riina Nieminen1, Teemu Moilanen2 and Eeva Moilanen1, 1The Immunopharmacology Research Group, University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland, 2The Immunopharmacology Research Group, University of Tampere School of Medicine, Tampere University Hospital, and Coxa Hospital for Joint Replacement, Tampere, Finland
Mast Cell-Restricted, Tetramer-Forming Tryptases Are Novel Mediators of Articular Cartilage Aggrecanolysis by Activating Matrix Metalloprotease Zymogens
Natalia Magarinos1, Katherine J. Bryant1, Amanda J. Fosang2, Richard L. Stevens3 and H. Patrick McNeil1, 1University of New South Wales, Sydney, Australia, 2University of Melbourne, Melbourne, Australia, 3Brigham & Women's Hospital and Harvard Medical School, Boston, MA
Calcium Mineral Deposition In the Cultures of Fibroblast-Like Synoviocytes
Yubo Sun, David Mauerhan, Atiya Franklin, Andrew Sun, Natalia Zinchenko, H. Norton, Edward Hanley Jr. and Helen Gruber, Carolinas Medical Center, Charlotte, NC
Infliximab Does Reverse Cytokine - Mediated Anti-Apoptotic Effects In CD14+/CD11b+ Circulating Monocytes – Implications for Osteoclastogenesis
Michael Seitz, Daniel Aeberli, Richard K. Kamgang, Willy Hofstetter, Deepak Balani and Peter M. Villiger, University Hospital, Bern, Switzerland
New Alginate-Chitosan Hydrogel Beads with Anti-Inflammatory and Anabolic Effects on Human Chondrocytes
Frédéric Oprenyeszk1, Christelle Sanchez1, Jean-Emile Dubuc2, Véronique Maquet3 and Yves Henrotin4, 1University of Liège, Liège, Belgium, 2Clinical University Saint Luc, Bruxelles, Belgium, 3KitoZyme SA, Herstal, Belgium, 4Univ of Liege/Pathology Inst, Liege, Belgium
Activation of Adenosine A2A Receptors Prevents Wear Particle-Induced Osteolysis
Aranzazu Mediero1, Sally Frenkel2, Tuere Wilder1 and Bruce N. Cronstein3, 1NYU School of Medicine, New York, NY, 2Hospital for Joint Disease, New York, NY, 3New York Univ Medical Center, New York, NY
Heme Oxygenase-1 Lentiviral Transduction of Human Osteoarthritic Osteoblasts Down-Regulates Inflammatory, Degradative and Senescence Markers
Maria Isabel Guillen1, Victoria Clerigues1, Miguel Angel Castejon2, Francisco Gomar3 and Maria Jose Alcaraz1, 1University of Valencia, Burjasot, Valencia, Spain, 2La Ribera Hospital, Alzira, Valencia, Spain, 3University of Valencia and University Hospital, Valencia, Spain
Human End-Stage Osteoarthritic Cartilage is Responsive to Transforming Growth Factor Beta and Contains a Population of Cells That Expresses SMAD2/3P and SMAD1/5/8P
Arjan P. M. van Caam, Esmeralda N. Blaney Davidson, Elly L. Vitters, Wim B. van den Berg and Peter M. van der Kraan, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
A Single Injection of Adipose-Derived Stem cells protects Against Cartilage Damage and Lowers Synovial Activation in Experimental Osteoarthritis
Menno C. ter Huurne1, Peter L.E.M. van Lent1, Arjen B. Blom1, Roxane Blattes2, Yannick Jeanson2, Louis Casteilla2, Christian Jorgensen3 and Wim B. van den Berg1, 1Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 2INSERM U1031, Toulouse, France, 3Hospital Lapeyronie, Montpellier, France
Chondrocytes in a Subset of Osteo-Arthritic Patients with Reduced NuclearFactorkappaB-p65 Levels Are Vulnerable to Apoptosis Induced by Tumor Necrosis Factor Alpha, Which Could Be Released by the Synovium
Onno J. Arntz, Eline A. Vermeij, Esmeralda N. Blaney Davidson, Shahla Abdollahi-Roodsaz, Miranda B. Bennink, Peter M. van der Kraan, Wim B. van den Berg and Fons Van De Loo, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
Adipokines Leptin and Adiponectin Correlate with Matrix Metalloproteinases and Interleukin-6 in Synovial Fluid From Osteoarthritis Patients and Enhance Their Production in Osteoarthritic Cartilage Ex Vivo
Katriina Vuolteenaho1, Anna Koskinen1, Sami Juslin1, Riina Nieminen1, Teemu Moilanen2 and Eeva Moilanen1, 1The Immunopharmacology Research Group, University of Tampere School of Medicine, and Tampere University Hospital, Tampere, Finland, 2Coxa Hospital for Joint Replacement, Tampere, Finland
Adenosine A1 Receptor Blockade Inhibits Osteoclast Formation of Mouse Bone Marrow Cells by Downregulation RANKL Signaling
Wenjie He, NYU, New York, NY and Bruce N. Cronstein, New York Univ Medical Center, New York, NY
MAPK-Activated Protein Kinase-2 (MK2) Regulates Bone Homeostasis
Tobias Braun1, Johannes Lepper1, Gisela Ruiz Heiland1, Georg Schett1 and Jochen Zwerina2, 1University of Erlangen-Nuremberg, Erlangen, Germany, 2Hanusch Hospital, Vienna, Austria
Human MSCs Ameliorate Bone Erosion in TNF-Alpha Transgenic Mice
Joy M. Whitbred1, Robert M. Lowe2, Donald P. Lennon3, Joseph Molter4, Chris A. Flask4, Tracey L. Bonfield2, Arnold I. Caplan3 and Nora G. Singer1, 1Division of Rheumatology, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH, 2Department of Pediatrics, Case Western Reserve University, Cleveland, OH, 3Skeletal Research Center, Case Western Reserve University, Cleveland, OH, 4Department of Radiology, Case Western Reserve University, Cleveland, OH
The Role of Mir-29 in the Chondrogenic Differentiation of Mesenchymal Stem Cells
D. Guerit1, D. Philipot2, P. Chuchana1, JM Brondello2, Christian Jorgensen3 and Daniele Noel2, 1INSERM U844, Montpellier, France, 2UM1, Montpellier, France, 3CHU Lapeyronie, Montpellier, France
Activation of AMP-Activated Protein Kinase (AMPK) Alleviates Endoplasmic Reticulum (ER) Stress and Inhibits Catabolic Responses to Biomechanical Injury in Chondrocytes
Freyr Petursson1, Xianling Zhao1, Robert Terkeltaub2 and Ru L. Bryan1, 1UCSD/VAMC, San Diego, CA, 2VA Medical Ctr, San Diego, CA
Apolipoprotein E and Undercarboxylated Osteocalcin Are Associated with Bone Fragility but Not with Bone Mineral Density in Osteoarthritis Patients
Ana M. Rodrigues1, Joana Caetano-Lopes2, Ana Lopes3, Ana Catarina Vale4, Inês Aleixo3, Inês P. Perpétuo2, Ana Sofia Pena3, Alexandra Faustino3, Alexandre Sepriano3, Joaquim Polido-Pereira5, Elsa Vieira-Sousa6, Bruno Vidal7, JC Romeu8, PM Amaral4, Luis G. Rosa4, José A. Pereira da Silva9, Jacinto Monteiro10, Maria Fátima Vaz4, J. E. Fonseca5 and Helena Canhão5, 1Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa and Rheumatology Department, Centro Hospitalar de Lisboa Norte, EPE, Hospital de Santa Maria, Lisbon, Portugal, 2Rheumatology Research Unit, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal, 3Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal, 4Department of Mechanical Engineering, Instituto Superior Técnico, ICEMS, Lisbon, Portugal, 5Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa and Rheumatology Department, Centro Hospitalar de Lisboa Norte, EPE, Hospital de Santa Maria, Lisboa, Portugal, 6Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal, 7Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal., Lisbon, Portugal, 8Hospital de Santa Maria, Lisbon, Portugal, 9Rheumatology Department, Centro Hospitalar de Lisboa Norte, EPE, Hospital de Santa Maria, Lisbon, Portugal, 10Orthopaedics Department, Hospital de Santa Maria, Lisbon, Portugal
Alarmins s100a8 and s100a9 Elicit a Higher Catabolic Response in Osteoarthritic Chondrocytes Compared to Normal Chondrocytes That Is Toll Like Receptor 4 Dependent
Rik Schelbergen1, Arjen B. Blom1, Martijn H.J. van den Bosch1, Annet Sloetjes1, Thomas Vogl2, Johannes Roth2, Wim B. van den Berg1 and Peter L.E.M. van Lent1, 1Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 2University of Muenster, Munster, Germany
Periostin, An Osteoblast Stimulating Factor, Regulates Cartilage Metabolism Via MMP-13 Activation
Mukundan Attur1, Glyn Palmer1, Yuki Tachida2, Seiichiro Kumakura2, Kohei Shimada2 and Steven B. Abramson1, 1NYU Hospital for Joint Diseases, New York, NY, 2Daiichi-Sankyo Co. Ltd.,, Tokyo, Japan
Sirt1 Deficient Mice Exhibit An Altered Cartilage Phenotype
Odile H. Gabay Engel1, Christelle Sanchez2, Mona dvir-Ginzberg3, Viktoria Gagarina1, Eun Jin Lee1, Kristien J. Zaal1, Michael McBurney4 and David J. Hall1, 1NIH, Bethesda, MD, 2Bone and Cartilage Research Unit, Liege, Belgium, 3Hebrew University- Hadassah Ein Kerem, Jerusalem, Israel, 4Ottawa Hospital, Ottawa, ON
Rac1 and NADPH Oxidase Regulate NFκB Activity and MMP-13 Expression in Chondrocytes in Response to Integrin Activation  
Richard F. Loeser, Elizabeth A. Erickson and David A. Long, Wake Forest University, Winston-Salem, NC
Disease-Specific Induction of Fibroblast Activation Protein Alpha in Rheumatoid Arthritis
Christina Wunrau1, Marianne Heitzmann1, Corinna Wehmeyer1, George Kollias2, Thomas Pap1 and Berno Dankbar1, 1University Hospital Muenster, Muenster, Germany, 2Biomedical Sciences Research Center 'Alexander Fleming', Vari, Greece
Theragnostic Nanosomes for Detection and Treatment of Early Osteoarthritis and Cartilage Damage
Karen A. Hasty, University of Tennessee Health Science Center, VA Medical Center, Memphis, TN, Hongsik Cho, University of Tennessee Health Science Center, Memphis, TN, Eugene Pinkhassik, University of Memphis, Memphis, TN and John M. Stuart, VA Medical Center, University of Tennessee Health Science Center, Memphis, TN
Sclerostin Levels in RA and Its Relationship to Disease Activity and Radiographic Joint Damage
M. Vis1, K. Britsemmer2, A.C. Heijboer1, N. Bravenboer1, D. van Schaardenburg2 and W. F. Lems1, 1VU University medical center, Amsterdam, Netherlands, 2Jan van Breemen Research Institute / Reade, Amsterdam, Netherlands
A Novel Method of Basic Calcium Phosphate Crystal Quantification in Synovial Fluid Using a Tetracycline Binding Assay
Jonathan Kushi1, Claudia Gohr1, Brian Jubeck1, Peter A. Simkin2 and Ann K. Rosenthal1, 1Medical College of Wisconsin, Milwaukee, WI, 2University of Washington, Seattle, WA
Revisiting Chemical and Morphological Diversity of Calcium-Containing Crystals in Human Osteoarthritic Menisci
Christelle Nguyen1, Frédéric Lioté1, Didier Hannouche2, Valérie Bousson3, Frédéric Velard1, Michel Daudon4, Dominique Bazin5 and Hang-Korng Ea1, 1UMR-S 606, INSERM & Paris Diderot University; PRES Sorbonne Paris-Cité; Lariboisière Hospital, Paris, France, 2Orthopaedic Surgery Department; Lariboisière Hospital (AP-HP); Univ. Paris Diderot, Sorbonne Paris-Cité, Paris, France, 3Radiology Department; Lariboisière Hospital (AP-HP); University Paris Diderot, Paris, France, 4Service de Biochimie A; Necker Hospital (AP-HP), Paris, France, 5Laboratoire de Physique des Solides; Paris Sud University, Orsay, France
Human Chondrocyte Behaviour During In Vitro Over Expression of Normal and Mutated HFE, the Hemochromatosis Gene
Vanessa Martelli1, John A. Di Battista1, Pantelis Panopalis1, John Antoniou2, Michael Sebag1, Brian Gilfix1 and Henri A. Ménard1, 1McGill University Health Center, Montreal, QC, 2Jewish General Hospital, Montreal, QC
Blockade of Delta-like1 Suppresses Osteoclastgenesis and Arthritis
Chiyoko Sekine1, Akemi Koyanagi1, Noriko Koyama1, Katsuto Hozumi2, Shigeru Chiba3 and Hideo Yagita1, 1Juntendo University School of Medicine, Tokyo, Japan, 2Tokai University School of Medicine, Japan, 3University of Tsukuba, Tsukuba, Japan
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