T-cell Biology and Targets in Autoimmune Disease: Lymphocyte Biology and Targets in Autoimmune Disease

Session Type: ACR Abstract Submissions
Tuesday, November 8, 2011: 9:00 AM-6:00 PM
Hall F2 - Poster Hall (McCormick Place West)
Papers:
Methylprednisolone Modulates MicroRNA and Gene Expression in Human CD4+ T Cells: A Novel Mechanism of Anti-Inflammatory Action
Trevor E. Davis, Floating Hospital for Children at Tufts Medical Center; Beth Israel Deaconess Medical Center, Boston, MA, Katalin Kis-Toth, Beth Israel Deaconess Medical Center, Boston, MA, Attila Szanto, Harvard Medical School; Massachusetts General Hospital, Boston, MA, Laurie C. Miller, Tufts Medical Center, Boston, MA and George C. Tsokos, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
Deficient Thymic T Lymphopoeisis in Rheumatoid Arthritis Is Not Due to the Lack of CD34+ Lymphoid progenitors
Manuela Rossol1, Anett Schulz1, Annika Schatz2, Undine Meusch2, Dagmar Quandt2, Christoph G. Baerwald3 and Ulf Wagner3, 1Translationszentrum für Regenerative Medizin (TRM), University of Leipzig, Leipzig, Germany, 2University of Leipzig, Leipzig, Germany, 3University Hospital, Leipzig, Germany
Synovial Fluid Vγ9Vδ2 T Cells Activated by Synovial Fibroblasts  Induce Their Apoptosis
Anna Bendersky1, Victoria Marcu1, Yackov Berkun2, Itamar Goldstein1, Maya Gerstein1, Shay Padeh1 and Ilan Bank1, 1Sheba Medical Center, Ramat Gan, Israel, 2Hadassah Hebrew University Medical Center, Jerusalem, Israel
Defining Pathogenicity of Human Th17 Cells in RA
Hiroshi Kato1, Judith Endres1 and David A. Fox2, 1University of Michigan, Ann Arbor, MI, 2Univ of Michigan Med Ctr, Ann Arbor, MI
T Cell Receptor Signal Strength Controls Onset and Severity of Arthritis in Antigen (Proteoglycan Epitope)-Specific T Cell Receptor Transgenic Mice
Katalin Olasz1, Ferenc Boldizsar1, Katalin Kis-Toth2, Oktavia Tarjanyi1, Akos Hegyi3, Willem van Eden4, Tibor A. Rauch3, Katalin Mikecz3 and Tibor T. Glant3, 1Pecs, Hungary, 2Boston, MA, 3Rush University Medical Center, Chicago, IL, 4Utrecht,, Netherlands
Short Combination Therapy with Anti-CD3 and Anti-TNF Is Associated with Long Term Inhibition of Established Collagen-Induced Arthritis
Fabien Depis1, Eric Hatterer1, Céline Lamacchia2, Cem Gabay3, Jean-Marc Waldburger2, Walter Reith4, Marie Kosco-Vilbois1 and Yann Dean1, 1NovImmune S.A., Plan-Les-Ouates, Geneva, Switzerland, 2University Hospitals of Geneva, Geneva, Switzerland, 3MD, Geneva, Switzerland, 4University of Geneva Medical School, Geneva, Switzerland
Antigen-Specific Regulatory Tr1 Lymphocytes As New Cell-Therapy Approach for Immunotherapy in Arthritis
Delphine Martire1, Julie Quentin1, Anne-Laure Mausset-Bonnefont1, Helène Asgnali2, Nathalie Belmonte2, Arnaud Foussat2, Christian Jorgensen3 and Pascale Louis-Plence1, 1Inserm U844, Montpellier, France, 2TxCell, Valbonne-Sophia Antipolis, France, 3CHU Lapeyronie, Montpellier, France
Investigation of Fibrinogen-Reactive T Cells in the Pathogenesis of Mouse Models of Rheumatoid Arthritis
Kristen N. Cordova1, Rocky L. Baker1, Gene Barbour1, Kathryn Haskins1 and V. Michael Holers2, 1University of Colorado, AMC, Aurora, CO, 2Univ of Colorado School of Med, Aurora, CO
Lysophosphatidylcholine Enhances Suppressive Function of Human Naturally Occurring Regulatory T Cells Through TGF-Beta Production
Hitoshi Hasegawa, Jin Lei, Takuya Matsumoto, Sachiko Onishi, Koichiro Suemori and Masaki Yasukawa, Ehime University Graduate School of Medicine, Toon, Japan
Multifunctional T Cell Reactivity to Native and Glycosylated Type-II Collagen in Rheumatoid Arthritis
Vivianne Malmström1, Omri Snir1, Johan Bäcklund2, Lars Klareskog1 and Rikard Holmdahl1, 1Karolinska Institutet, Stockholm, Sweden, 2Karolinska Institutet, Stcokholm, Sweden
Circulating CD4+CD161+ T Cells As Biomarker of Disease Activity in Recently Diagnosed, Non- Treated Rheumatoid Arthritis Patients
Paulina Chalan, Wayel H. Abdulahad, Minke G. Huitema, Bart-Jan Kroesen, Elisabeth Brouwer and Annemieke M.H. Boots, University Medical Center Groningen, Groningen, Netherlands
CIRCULATING HUMAN Collagen II- REACTIVE T CELL In EARLY Rheumatoid Arthritis  PRODUCE IL17
Anna Laura Fedele1, Chiara Nicolò2, Gabriele Di Sante2, Barbara Tolusso1, Silvia L. Bosello1, Elisa Gremese1, Francesco Ria2 and Gianfranco Ferraccioli1, 1Division of Rheumatology, Catholic University of the Sacred Heart, Rome, Italy, 2Institute of General Pathology, Catholic University of the Sacred Heart, Rome, Italy
A Novel Human Autoantigen Induces T and B Cell Responses in Patients with Antibiotic-Refractory Lyme Arthritis
Elise E. Drouin1, Robert J. Seward2, Chunxiang Yao3, Kianoosh Katchar1, Gail McHugh1, Klemen Strle1, Catherine E. Costello3 and Allen C. Steere1, 1Massachusetts General Hospital and Harvard Medical School, Boston, MA, 2Massachusetts General Hospital, Harvard Medical School and Boston University School of Medicine, Boston, MA, 3Boston University School of Medicine, Boston, MA
IL-2/IL-2mAb Complex Induced Expansion of Treg Cells and Prolonged Suppression of Collagen Induced Arthritis in Mice by Fortifying IL-2 Signaling Pathways
seon Yeong Lee1, Hye Jwa Oh1, Joo-Yeon Jhun1, Jun Geol Ryu1, Mi La Cho1, ji Hyeon Ju1, Sang Heon Lee2, Sung Hwan Park1, Charles D. Surh3 and Ho Youn Kim1, 1Rhematism Research Center, Seoul, South Korea, 2Division of Rheumatology, Seoul, South Korea, 3Department of Immunology
High Density Lipoproteins Stabilize Antigen Presenting Cell:T Cell Conjugates by Altering the T Cell Receptor Signalling Kinetics
A.L. Gomes1, J. Delgado-Alves1 and E.C. Jury2, 1Faculdade de Ciências Médicas da Universidade Nova de Lisboa, Lisboa, Portugal, 2University College London, London, United Kingdom
The Induction of c-Maf in Th17 Cells and Its Implications in the Development of Memory Th Cells
Kojiro Sato, Fumihiko Miyoshi and Toshihide Mimura, Saitama Medical University, Saitama, Japan
A Novel Role for Vitamin D in Immunosenescence: Is Enough Too Much for Naïve CD8 T Cells?
Yong Gil Hwang1, Fei Chu Lim1, Qi Wu1, PingAr Yang1, Gordon Fisher2, Gary Hunter3, Hui-Chen Hsu1 and John D. Mountz4, 1University of Alabama at Birmingham, Birmingham, AL, 2Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA, 3Department of Human Studies, University of Alabama at Birmingham, Birmingham, Alabama, USA, 4University of Albama at Birmingham/Birmingham VA Medical Center, Birmingham, AL
AKAP79 Expression Is Increased in Systemic Lupus Erythematosus T Cells and Reduces IL2 Production
Gabriel Criado, María Galindo, A. Javier García-González, Jose L. Pablos and María J. Pérez-Lorenzo, Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain
Oxidation Impairs PKCä Signaling in Lupus
Gabriela Gorelik and Bruce C. Richardson, University of Michigan, Ann Arbor, MI
Linker for Activation of T Cells Is Displaced From the Immunological Synapse in Lupus T Cells After T Cell Activation
Nursamaa Abdoel1, Carmen Bracho2, Martin A. Rodriguez1 and Ana M. Blasini1, 1Hospital Universitario de Caracas, Caracas, Venezuela, 2Instituto Venezolano de Investigaciones Científicas, Miranda, Venezuela
Effects of Direct Ras Inhibition on Lupus T Cell Cytokine Secretion
Ioana Moldovan, Leticia Ortloff, Adrian Costinescu, Keith K. Colburn and Lora Green, Loma Linda University, Loma Linda, CA
A Progesterone Receptor Regulates T Helper Cell Type 1 Functions and T Cell-Dependent Antibody Responses In Vivo
Alan Wong, Edward A. Clark and Grant C. Hughes, University of Washington, Seattle, WA
The Autoantibody-Inducing CD4 T Cell (aiCD4 T cell) Which Induces Systemic Lupus Erytematosus (SLE) Belongs to CD45RBlo 122lo Subpopulation
Yumi Miyazaki1, Ken Tsumiyama1 and Shunichi Shiozawa2, 1Kobe University Graduate School of Health Science, Kobe, Japan, 2Kobe University Graduate School of Health Science and Medicine/ The Center for Rheumatic Diseases, Kobe University Hospital, Kobe, Japan
Sex-Specific Effects of Segmented Filamentous Bacteria In the Autoimmune-Prone NOD Mouse Strain – Segregation with Diabetes Protection In Females but Not Males
Martin A. Kriegel1, Esen Sefik2, Jonathan A. Hill2, Hsin-Jung Wu2, Christophe Benoist2 and Diane Mathis2, 1Brigham & Women's Hospital/Harvard Medical School, Boston, MA, 2Harvard Medical School, Boston, MA
Expansions of Interleukin-21-Secreting CD4+ T Helper Cells in Inflammatory Arthritides
Pedro L. Vieira1, Maria C. Lebre2, Saïda Aarrass2, Thomas Newsom-Davis1, PP. Tak2 and Gavin R. Screaton1, 1Imperial College London, London, United Kingdom, 2Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
Th17 but Not Th22 Cells Display Pathological Behaviour in Rheumatoid Arthritis Synovial Inflammation
Jan Piet van Hamburg, Odilia B.J. Corneth, Sandra M.J. Paulissen, Nadine Davelaar, Patrick S. Asmawidjaja and Erik Lubberts, Erasmus MC, University Medical Center, Rotterdam, Netherlands
HRES-1/Rab4 Lupus Susceptibility Gene Selectively Regulates Mammalian Target of Rapamycin Complexes 1 and 2 in T Lymphocytes
Tiffany Telarico1, Gabriella Miklossy2, David Sabatini3, David Kwiatkowski4, Nahum Sonenberg5 and Andras Perl2, 1SUNY Upstate Medical University, Syracuse, NY, 2Upstate Medical University, Syracuse, NY, 3Whitehead Institute for Biomedical Research, Cambridge, MA, 4Brigham and Women's Hospital, Boston, MA, 5Goodman Cancer Research Centre, McGill University, Montreal, QC
Abatacept (CTLA-4Ig) Treatment Reduces Activation Induced Cell Death (AICD) and Susceptibility of T Cells to Regulatory T Cell Suppression in Patients with Rheumatoid Arthritis (RA)
Michael Bonelli1, Lisa Goeschl1, Stefan Blueml1, Anastasiya Hladik1, Emmi Puujalka1, Carl-Walter Steiner1, Josef Smolen2 and Clemens Scheinecker1, 1Medical University of Vienna, Vienna, Austria, 2Medical University of Vienna and Hietzing Hospital, Vienna, Austria
Do Immune Complexes (ICs) Binding Low Affinity FcγRIIIA/B Bearing CD4+ T Cells Contribute to the Autoimmune Pathology?
Anil K. Chauhan, Saint Louis University, St. Louis, MO and Terry L. Moore, Saint Louis University, Saint Louis, MO
Leptin Modulates Apoptosis of Autoimmune T Cells in Systemic Lupus Erythematosus
Gil Amarilyo, UCLA, Los Angeles, CA, Noriko Iikuni, UCLA, CA, Bevra H. Hahn, UCLA David Geffen School of Medicine, Los Angeles, CA and Antonio La Cava, Univ of California Los Angeles, Los Angeles, CA
Identification of a CD62LhiCD44low TFH Precursor Capable of Developing into  An IL21hi IL17hi Mature TFH in Autoimmune BXD2 Mice
Yanna Ding1, Hui-Chen Hsu1 and John D. Mountz2, 1University of Alabama at Birmingham, Birmingham, AL, 2University of Alabama at Birmingham and Birmingham VAMC, Birmingham, AL
Effects of Altering Fli1 Levels in Lupus T Cells on Disease Expression and T Cell Function in the MRL/Lpr Mouse Model
Fahmin Basher1, Marlene Bunni1, Zainab Amani1, Xian Zhang2 and Tamara K. Nowling2, 1Medical University of South Carolina, Charleston, SC, 2Medical University of South Carolina & Ralph H Johnson VA Medical Center, Charleston, SC
DNA Methylation Regulates Gene Expression in CD4+CD28- T Cells Through Micrornas
Dipak R. Patel, Anura Hewagama, Gabriela Gorelik, Sushma Yarlagadda, Faith Strickland and Bruce C. Richardson, University of Michigan, Ann Arbor, MI
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