Innate Immunity and Rheumatic Disease

Session Type: ACR Abstract Submissions
Monday, November 7, 2011: 9:00 AM-6:00 PM
Hall F2 - Poster Hall (McCormick Place West)
Papers:
A Toll-Like Receptor 1 Polymorphism Is Associated with Heightened T Helper 1 Responses and Antibiotic-Refractory Lyme Arthritis
Klemen Strle, Junghee J. Shin, Lisa Glickstein and Allen C. Steere, Massachusetts General Hospital, Harvard Medical School, Boston, MA
Toll Like Receptor-2 Activation Prevents Cartilage Damage in Osteoarthritis Models That Display Synovial Activation
Arjen Blom, Peter van Lent, Shahla Abdollahi-Roodsaz, Peter M. van der Kraan and Wim B. van den Berg, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
NI-0101, a Therapeutic TLR4 Monoclonal Antibody for Rheumatoid Arthritis
Greg Elson1, Theresa Page2, Vanessa Buatois1, Bruno Daubeuf1, Laurence Chatel1, Laura Cons1, Carla Lippens1, Susana Salgado-Pires1, Walter Ferlin1, Marie Kosco-Vilbois1, Kim Midwood2 and Limin Shang1, 1NovImmune S.A., Plan-Les-Ouates, Geneva, Switzerland, 2Kennedy Institute of Rheumatology, Imperial College of Science, Technology and Medicine, London, United Kingdom
MiR-20a Regulates Negatively TLR4 Signalling Pathway by Targeting ASK1 in Rheumatoid Synoviocytes
Lucas Philippe1, Ghada Alsaleh1, Sébastien Pfeffer2, Jacques-Eric Gottenberg1, Jean Sibilia1, Dominique Wachsmann1 and Philippe Georgel3, 1EA4438 Laboratoire Physiopathologie des Arthrites, Illkirch-Strasbourg, France, 2Architecture et Réactivité de l'ARN, Université de Strasbourg, Strasbourg, France, 3Laboratoire d'ImmunoGénétique Moléculaire Humaine, Strasbourg, France
TIR-Domain-Containing Adaptor-Inducing Interferon-β (TRIF)-Dependent Toll-Like Receptor 4 Signaling Mediates Antibody Class Switching in a Mouse Model of Histidyl-tRNA Synthetase-Induced Myositis
Lisa Harlow, University of Miami Miller School of Medicine, Miami, FL, Makoto Soejima, University of Pittsburgh, Pittsburgh, PA and Dana P. Ascherman, University of Miami, Miami, FL
Presence of Fas Associated Death Domain Protein in the Synovial Fluids and Sera (ESPOIR Cohort) of Rheumatoid Arthritis Patients Mirrors the Inflammatory Attribute of the Disease
Léa Tourneur1, Sylvie Mistou1, Valérie Vilmont1, Nicolas Cagnard2, Jacques-Eric Gottenberg3, Valerie Devauchelle4 and Gilles Chiocchia2, 1Institut Cochin, Paris, France, 2Institut Cochin, 75014 Paris, France, 3Strasbourg University Hospital, Strasbourg, France, 4Brest university medical school, EA 2216, UBO and CHU de la Cavale Blanche,, Brest, France
TLR4 on Resident Cells and Bone Marrow Derived Cells Contribute Equally to Arthritis
Ben T. van Den Brand1, Shahla Abdollahi-Roodsaz1, Miranda B. Bennink2, Onno J. Arntz2, Wim van den Berg1 and Fons A. van de Loo1, 1Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 2Nijmegen, Netherlands
Toll-Like Receptor-9 Activation Regulates Macrophage Triggering Receptor Expressed on Myeloid Cells-1 Expression and shedding
Yair Molad, Felsenstein Medical Reseach Center, Sackler Faculty of Medicine, Tel Aviv University, and Beilinson Hospital, Rabin Medical Center, Petah Tikva, Israel, Elisheva Shapira, Beilinson Hospital, Rabin Medical Center, Petah Tikva, Israel and Vered Carmon, Laboratory of Inflammation Research, Felsenstein Medical Research Center, Tel Aviv University, Petah Tikva, Israel
A TLR 9 Antagonist Diminishes Arthritis Severity and Inhibits Bone Erosion in a Rat Model of Rheumatoid arthritis 
Sonja Herman1, Anita Fischer1, Markus Hoffmann2 and Gunter Steiner1, 1Medical University of Vienna, Vienna, Austria, 2Karolinska Institutet, Stockholm, Sweden
Upregulated High Mobility Group Box One Acts in Synergy with Danger Signals Through the Activation of of p38 Mitogen-Activated Protein Kinases to Promote Inflammation in Patients with Lupus Nephritis
Shui-Lian Yu, Chun-Kwok Wong, Da-Peng Chen, cheuk-Chun Szeto, Edmund K. Li and Lai-Shan Tam, The Chinese University of Hong Kong, Hong Kong, China
The Anti-Inflammatory Action of Nerve Growth Factor Is Mediated by Trka Signalling: Modification in Trka Expression in Juvenile Idiopathic Arthritis Mononuclear Cells Create An Unbalance Between Inflammatory and Anti-Inflammatory Pathways?
Gaetana Minnone1, Giusi Prencipe1, Raffaele Strippoli1, Loredana De Pasquale1, Ivan Caiello1, Fabrizio De Benedetti1 and Luisa Bracci-Laudiero2, 1Children Hospital Bambino Gesù, Rome, Italy, 2Institure of Translational Pharmacology-CNR, Rome, Italy
Dysregulation of Pyrin, the Familial Mediterranean Fever Protein, Exacerbates Endotoxin-Induced Uveitis in Mice
Holly L. Rosenzweig1, Jenna S. Clowers2, Jordan Allensworth1, Emily E. Vance1, Stephen R. Planck1, Michael P. Davey2, Jae Jin Chae3, Daniel L. Kastner4 and James T. Rosenbaum1, 1Oregon Health & Science University, Portland, OR, 2Veterans Affairs Medical Center, Portland, OR, 3Medical Genetics Branch, National Human Genome Research Institute, MD, 4National Human Genome Research Institute, National Institutes of Health, Bethesda, MD
Expression and Function of the NALP3 Inflammasome in Behçet’s Disease
En Hyung Kim1, Jae Young Shin2, Mi-Jin Park2, Sun Park2 and Eun-So Lee2, 1Kwan Dong University, Cheil General Hospital and Women's Healthcare Center, Seoul, South Korea, 2Ajou University School of Medicine, Suwon, South Korea
Demographic and Genetic Results From the EUROFEVERS/EUROTRAPS Consortia in the Largest Series of Patients with TRAPS Yet Reported
Helen J. Lachmann1, Antonella Meini2, Isabelle Touitou3, Laura Obici4, Martina Finetti5, Kirsten Minden6, Luca Cantarini7, Marine Desjonqueres8, Joost Frenkel9, Isabelle Kone-Paut10, Olga Vougiouka11, Maria Jesus Rua Elorduy12, Nicola Ruperto13, Patricia Woo1 and Marco Gattorno14, 1University College London Medical School, London, United Kingdom, 2Dipartimento di Pediatria, University of Brescia, Brescia, Italy, 3CHU Montpellier - Hôpital Arnaud de Villeneuve, Montpellier, France, 4IRCCS Policlinico S. Matteo, Pavia, Italy, 5IRCCS Istituto G. Gaslini, Genova, Italy, 6Charite, Berlin, Germany, 7Policlinico le Scotte, Sienna, Italy, 8Hopital Femme Mere Enfant, Groupement Hospitalier Est, Lyon, France, 9University Medical Center Utrecht, Utrecht, Netherlands, 10CHU Le Kremlin Bicetre, Paris, France, 11P. A. Kyriakou Childrens Hospital of Athens University, Athens, Greece, 12Hospital de Cruces, Barakaldo, Spain, 13Paediatric Rheumatology International Trials Organisation – IRCCS [PRINTO], Genova, Italy, 14G Gaslini Institute, Genoa, Italy
The Pattern-Recognition Receptor NOD1 Promotes Production of Inflammatory Mediators in Different Cell Types of the Synovium in Rheumatoid Arthritis
Kazuhiro Yokota1, Toshihide Mimura2, Renate E. Gay1, Steffen Gay1, Christoph Kolling3 and Caroline Ospelt1, 1Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, 2Saitama Medical University, Saitama, Japan, 3Schultess Clinic, Zurich, Switzerland
Innate Immune Stimulation Triggers Early-Onset Spondyloarthritis in HLA-B27/Human beta2 Microglobulin Transgenic Rats
Leonie M. van Duivenvoorde1, Gleb M. Slobodin2, Nimman Satumtira2, Martha L. Dorris2, Paul P. Tak3, Dominique L. Baeten1 and Joel D. Taurog2, 1Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, 2UT Southwestern Medical Center, Dallas, TX, 3Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam The Netherlands, Amsterdam, Netherlands
Dual Signaling Pathways Dependent Upon the Adaptor Protein SLP-76 Lead to Distinct Natural Killer Cell Effector Functions
Rebecca May1, Chih-Jung Hsu1, Mariko Okumura1, Gary A. Koretzky2 and Taku Kambayashi1, 1University of Pennsylvania, Philadelphia, PA, 2University Pennsylvania, Philadelphia, PA
Untreated Juvenile Dermatomyositis: Altered Peripheral Blood Natural Killer Cell Receptors Associated with Increased Natural Killer Cell Localization in Inflamed Muscle
Sheela Shrestha1, Maurice O'Gorman2, Jordan Orange3, Chelsea Tessler-Verville1, Katelin Snow1, Gabrielle Morgan1, Deli Wang4 and Lauren M. Pachman2, 1Children's Memorial Hospital, Chicago, IL, 2Northwestern University Feinberg School of Medicine, Chicago, IL, 3Children's Hospital of Philadelphia, Philadelphia, 4Northwestern University's Feinberg School of Medicine, Chicago, IL
Antigen Cross-Presentation Is Essentially Required for the Pathogenesis of Lupus Nephritis: Essential Role of Endosomal Trafficking
Ken Tsumiyama1, Mai Takimoto1 and Shunichi Shiozawa2, 1Kobe University Graduate School of Health Science, Kobe, Japan, 2Kobe University Graduate School of Health Science and Medicine/ The Center for Rheumatic Diseases, Kobe University Hospital, Kobe, Japan
Immune-Complex Induced Inflammation Is Augmented in the Absence Nicotinic Acetylcholine Receptors in Mice
Milena Vukelic1, Gloria Koo1, Patricia M. Redecha1 and Jane E. Salmon2, 1Hospital for Special Surgery, New York, NY, 2Hospital for Special Surgery, Weill Cornell Medical College, New York, NY
Association of Functional Fcgammariic (FCGR2C) Polymorphisms with Rheumatoid Arthritis in African Americans
Jianming Wu1, Xinrui Li2, Rui Lin3, Howard Wiener4, Hemant Tiwari4, Cunren Liu4, Travis Ptacek2, Jeffrey C. Edberg5, S. Louis Bridges Jr.6 and Robert P. Kimberly4, 1University of minnesota, St. Paul, MN, 2University of Alabama at Birmingham, Brimingham, AL, 3University of Minnesota, St. Paul, MN, 4University of Alabama at Birmingham, Birmingham, AL, 5Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 6Marguerite Jones Harbert-Gene V. Ball, MD Professor of Medicine, and Director, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Low Copy Number of Fcgamma Receptor 3B Gene Is a Disease Susceptibility and Severity Factor in Primary Sjøgren’s Syndrome
Johannes C. Nossent1, Maureen Rischmueller2, Andrea Becker-Merok1 and Sue Lester2, 1University of Tromsø, Tromso, Norway, 2Queen Elizabeth Hospital, Adelaide, Australia
C1q Diverts Lupus Immune Complexes Away From CD14dimCD16+ “Patrolling” Monocytes
Pradipta Ghosh*, Alice Wiedeman*, Deanna M. Santer, Vivian E. Vlamakis and Keith B. Elkon, University of Washington, Seattle, WA
Functional Effects Attributable to the R77H Lupus Susceptibility Variant Encoded by ITGAM
Benjamin Rhodes1, Barbara G. Fürnrohr1 and Timothy J. Vyse2, 1King's College London, London, United Kingdom, 2Divisions of Genetics and Molecular Medicine and Immunology, King's College London, London, United Kingdom
Anti-Inflammatory Profile of AS2444697, A Novel Interleukin-1 Receptor-Associated Kinase-4 Inhibitor
Junko Imanishi, Takeshi Ishikawa, Emiko Imamura, Hidekazu Mizuhara, Haruna Iwaoka, Ball Evelyn, Hiroshi Inami, Tsuyoshi Mizutani, Junko Watanabe, Hiroyuki Usuda, Shinya Nagashima, Tomonori Ito, Toru Kontani, Yasuaki Shimizu and Seitaro Mutoh, Astellas Pharma Inc., Tsukuba, Japan
MicroRNA-15a Regulates Etk/BMX Expression and IL-6 Release In Activated Rheumatoid Synoviocytes
Ghada Alsaleh1, Lucas Philippe1, Angélique Pichot1, Sébastien Pfeffer2, Jacques-Eric Gottenberg1, Jean Sibilia1, Philippe Georgel3 and Dominique Wachsmann1, 1EA4438 Laboratoire Physiopathologie des Arthrites, Illkirch-Strasbourg, France, 2Architecture et Réactivité de l'ARN, Université de Strasbourg, Strasbourg, France, 3Laboratoire d'ImmunoGénétique Moléculaire Humaine, Strasbourg, France
Knock-Down of Galectin-3 Inhibits Spontaneous and Lipopolysaccharide -Induced IL-6 Secretion In Fibroblast-Like Synoviocytes
Uri Arad, Avital Angel-Korman, Sharon Amir, Sharon Tzadok, Ortal Seagal, Ori Elkayam and Dan Caspi, Tel Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
Vimentin Suppresses the Production of Reactive Oxygen Species and the Antimicrobial Response Via p47phox
Nirit Mor-Vaknin, Maureen Legendre, Yue Yu, Carlos H.C. Serezani, Sanjay Garg, Anna Jatzek, Michael D. Swanson, Seagal Teitz-Tennenbaum, Antonello Punturieri, N. Cary Engleberg, Ruma Banerjee, Marc Peters-Golden and David Markovitz, University of Michigan, Ann Arbor, MI
SNAPIN Is Overexpressed in Rheumatoid Arthritis Synovial Tissue and Involved in Endosomal Lysosomal Pathway
Bo Shi1, Qi Quan Huang1, Andrea Dorfleutner1, Christian Stehlik1, Paul P. Tak2 and Richard M. Pope1, 1Northwestern University, Feinberg School of Medicine, Chicago, IL, 2Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam The Netherlands, Amsterdam, Netherlands
Mechanisms of Human Monocytes and Macrophages to Adapt to Hypoxia
Monique Fangradt1, Timo Gaber1, Martin Hahne1, Paula Hoff1, Manuela Jakstadt1, Cindy Strehl1, Gerd-Rüdiger Burmester2 and Frank Buttgereit1, 1Charité University Medicine, Berlin, Germany, 2Charité University Hospital, Berlin, Germany
The Key Apoptotic Cell Receptor Mer and Its Ligand Gas6 Are Differentially Regulated in M2 Macrophage Subsets
Gaetano Zizzo, Brendan A. Hilliard, Marc Monestier and Philip L. Cohen, Temple University School of Medicine, Philadelphia, PA
Ly-6Chigh Monocytes Are Key Cells in Pathogenesis of Autoimmune Arthritis and May Be An Interesting Target for Immunotherapy
Jessy Presumey1, Gabriel Courties1, Virginie Escriou2, Daniel Scherman2, Diego Kyburz3, Steffen Gay4, Yves-Marie Pers5, Christian Jorgensen5 and Florence Apparailly1, 1Inserm, Montpellier, France, 2Inserm, Paris, France, 3University hospital of Zurich, Zurich, Switzerland, 4University Hospital of Zürich, Zürich, Switzerland, 5CHU Lapeyronie, Montpellier, France
Myeloid-Derived Suppressor Cells Present in the Synovial Fluid of Mice with Proteoglycan-Induced Arthritis Are Potent Suppressors of Dendritic Cell Maturation and T Cell Proliferation
Julia Kurko, Colt Egelston, Timea Besenyei, Beata Tryniszewska, Tamas Kobezda, Tibor A. Rauch, Tibor T. Glant and Katalin Mikecz, Rush University Medical Center, Chicago, IL
Analysis of the Expression of Interferon Regulatory Factors on Dendritic Cells From Systemic Lupus Erythematosus Patients
Karina Santana-de Anda, Adriana Elizabeth Monsivais-Urenda, Diana Gomez-Martin, Jose Cruz-Ruiz and Jorge Alcocer-Varela, Instituto Nacional de Ciencias Médicas y Nutrición, Salvador Zubirán, Mexico city, Mexico
Expression of Caspase 8 in Dendritic Cells Is More Potent Than in Myeloid Cells in the Prevention of SLE-Like Disease Onset
Carla M. Cuda1, Jaime Chowaniec1, Jack Hutcheson2, G. Kenneth Haines III3, Chandra Mohan2 and Harris R. Perlman4, 1Northwestern University Feinberg School of Medicine, Chicago, IL, 2University of Texas Southwestern Medical Center, Dallas, TX, 3Yale University, New Harven, CT, 4Northwestern University, Chicago, IL
Analysis of the Bioactive Molecules That Promote the Induction of Human Tolerogenic Dendritic Cells
Takuya Matsumoto, Hitoshi Hasegawa, Jin Lei, Koichiro Suemori, Sachiko Onishi and Masaki Yasukawa, Ehime University Graduate School of Medicine, Toon, Japan
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