The ACR thanks Genentech, A Member of the Roche Group, for support of the 2011 ACR/ARHP Annual Scientific Meeting My ACR.
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Innate Immunity and Rheumatic Disease
Session Type: ACR Abstract Submissions
Monday, November 7, 2011: 9:00 AM-6:00 PM
Hall F2 - Poster Hall (McCormick Place West)
Papers:
NI-0101, a Therapeutic TLR4 Monoclonal Antibody for Rheumatoid Arthritis
Greg Elson1, Theresa Page2, Vanessa Buatois1, Bruno Daubeuf1, Laurence Chatel1, Laura Cons1, Carla Lippens1, Susana Salgado-Pires1, Walter Ferlin1, Marie Kosco-Vilbois1, Kim Midwood2 and Limin Shang1, 1NovImmune S.A., Plan-Les-Ouates, Geneva, Switzerland, 2Kennedy Institute of Rheumatology, Imperial College of Science, Technology and Medicine, London, United Kingdom
MiR-20a Regulates Negatively TLR4 Signalling Pathway by Targeting ASK1 in Rheumatoid Synoviocytes
Lucas Philippe1, Ghada Alsaleh1, Sébastien Pfeffer2, Jacques-Eric Gottenberg1, Jean Sibilia1, Dominique Wachsmann1 and Philippe Georgel3, 1EA4438 Laboratoire Physiopathologie des Arthrites, Illkirch-Strasbourg, France, 2Architecture et Réactivité de l'ARN, Université de Strasbourg, Strasbourg, France, 3Laboratoire d'ImmunoGénétique Moléculaire Humaine, Strasbourg, France
TIR-Domain-Containing Adaptor-Inducing Interferon-β (TRIF)-Dependent Toll-Like Receptor 4 Signaling Mediates Antibody Class Switching in a Mouse Model of Histidyl-tRNA Synthetase-Induced Myositis
Lisa Harlow, University of Miami Miller School of Medicine, Miami, FL, Makoto Soejima, University of Pittsburgh, Pittsburgh, PA and Dana P. Ascherman, University of Miami, Miami, FL
Presence of Fas Associated Death Domain Protein in the Synovial Fluids and Sera (ESPOIR Cohort) of Rheumatoid Arthritis Patients Mirrors the Inflammatory Attribute of the Disease
Léa Tourneur1, Sylvie Mistou1, Valérie Vilmont1, Nicolas Cagnard2, Jacques-Eric Gottenberg3, Valerie Devauchelle4 and Gilles Chiocchia2, 1Institut Cochin, Paris, France, 2Institut Cochin, 75014 Paris, France, 3Strasbourg University Hospital, Strasbourg, France, 4Brest university medical school, EA 2216, UBO and CHU de la Cavale Blanche,, Brest, France
Toll-Like Receptor-9 Activation Regulates Macrophage Triggering Receptor Expressed on Myeloid Cells-1 Expression and shedding
Yair Molad, Felsenstein Medical Reseach Center, Sackler Faculty of Medicine, Tel Aviv University, and Beilinson Hospital, Rabin Medical Center, Petah Tikva, Israel, Elisheva Shapira, Beilinson Hospital, Rabin Medical Center, Petah Tikva, Israel and Vered Carmon, Laboratory of Inflammation Research, Felsenstein Medical Research Center, Tel Aviv University, Petah Tikva, Israel
The Anti-Inflammatory Action of Nerve Growth Factor Is Mediated by Trka Signalling: Modification in Trka Expression in Juvenile Idiopathic Arthritis Mononuclear Cells Create An Unbalance Between Inflammatory and Anti-Inflammatory Pathways?
Gaetana Minnone1, Giusi Prencipe1, Raffaele Strippoli1, Loredana De Pasquale1, Ivan Caiello1, Fabrizio De Benedetti1 and Luisa Bracci-Laudiero2, 1Children Hospital Bambino Gesù, Rome, Italy, 2Institure of Translational Pharmacology-CNR, Rome, Italy
Dysregulation of Pyrin, the Familial Mediterranean Fever Protein, Exacerbates Endotoxin-Induced Uveitis in Mice
Holly L. Rosenzweig1, Jenna S. Clowers2, Jordan Allensworth1, Emily E. Vance1, Stephen R. Planck1, Michael P. Davey2, Jae Jin Chae3, Daniel L. Kastner4 and James T. Rosenbaum1, 1Oregon Health & Science University, Portland, OR, 2Veterans Affairs Medical Center, Portland, OR, 3Medical Genetics Branch, National Human Genome Research Institute, MD, 4National Human Genome Research Institute, National Institutes of Health, Bethesda, MD
Expression and Function of the NALP3 Inflammasome in Behçet’s Disease
En Hyung Kim1, Jae Young Shin2, Mi-Jin Park2, Sun Park2 and Eun-So Lee2, 1Kwan Dong University, Cheil General Hospital and Women's Healthcare Center, Seoul, South Korea, 2Ajou University School of Medicine, Suwon, South Korea
Demographic and Genetic Results From the EUROFEVERS/EUROTRAPS Consortia in the Largest Series of Patients with TRAPS Yet Reported
Helen J. Lachmann1, Antonella Meini2, Isabelle Touitou3, Laura Obici4, Martina Finetti5, Kirsten Minden6, Luca Cantarini7, Marine Desjonqueres8, Joost Frenkel9, Isabelle Kone-Paut10, Olga Vougiouka11, Maria Jesus Rua Elorduy12, Nicola Ruperto13, Patricia Woo1 and Marco Gattorno14, 1University College London Medical School, London, United Kingdom, 2Dipartimento di Pediatria, University of Brescia, Brescia, Italy, 3CHU Montpellier - Hôpital Arnaud de Villeneuve, Montpellier, France, 4IRCCS Policlinico S. Matteo, Pavia, Italy, 5IRCCS Istituto G. Gaslini, Genova, Italy, 6Charite, Berlin, Germany, 7Policlinico le Scotte, Sienna, Italy, 8Hopital Femme Mere Enfant, Groupement Hospitalier Est, Lyon, France, 9University Medical Center Utrecht, Utrecht, Netherlands, 10CHU Le Kremlin Bicetre, Paris, France, 11P. A. Kyriakou Childrens Hospital of Athens University, Athens, Greece, 12Hospital de Cruces, Barakaldo, Spain, 13Paediatric Rheumatology International Trials Organisation – IRCCS [PRINTO], Genova, Italy, 14G Gaslini Institute, Genoa, Italy
The Pattern-Recognition Receptor NOD1 Promotes Production of Inflammatory Mediators in Different Cell Types of the Synovium in Rheumatoid Arthritis
Kazuhiro Yokota1, Toshihide Mimura2, Renate E. Gay1, Steffen Gay1, Christoph Kolling3 and Caroline Ospelt1, 1Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, 2Saitama Medical University, Saitama, Japan, 3Schultess Clinic, Zurich, Switzerland
Innate Immune Stimulation Triggers Early-Onset Spondyloarthritis in HLA-B27/Human beta2 Microglobulin Transgenic Rats
Leonie M. van Duivenvoorde1, Gleb M. Slobodin2, Nimman Satumtira2, Martha L. Dorris2, Paul P. Tak3, Dominique L. Baeten1 and Joel D. Taurog2, 1Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, 2UT Southwestern Medical Center, Dallas, TX, 3Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam The Netherlands, Amsterdam, Netherlands
Untreated Juvenile Dermatomyositis: Altered Peripheral Blood Natural Killer Cell Receptors Associated with Increased Natural Killer Cell Localization in Inflamed Muscle
Sheela Shrestha1, Maurice O'Gorman2, Jordan Orange3, Chelsea Tessler-Verville1, Katelin Snow1, Gabrielle Morgan1, Deli Wang4 and Lauren M. Pachman2, 1Children's Memorial Hospital, Chicago, IL, 2Northwestern University Feinberg School of Medicine, Chicago, IL, 3Children's Hospital of Philadelphia, Philadelphia, 4Northwestern University's Feinberg School of Medicine, Chicago, IL
Association of Functional Fcgammariic (FCGR2C) Polymorphisms with Rheumatoid Arthritis in African Americans
Jianming Wu1, Xinrui Li2, Rui Lin3, Howard Wiener4, Hemant Tiwari4, Cunren Liu4, Travis Ptacek2, Jeffrey C. Edberg5, S. Louis Bridges Jr.6 and Robert P. Kimberly4, 1University of minnesota, St. Paul, MN, 2University of Alabama at Birmingham, Brimingham, AL, 3University of Minnesota, St. Paul, MN, 4University of Alabama at Birmingham, Birmingham, AL, 5Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 6Marguerite Jones Harbert-Gene V. Ball, MD Professor of Medicine, and Director, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Anti-Inflammatory Profile of AS2444697, A Novel Interleukin-1 Receptor-Associated Kinase-4 Inhibitor
Junko Imanishi, Takeshi Ishikawa, Emiko Imamura, Hidekazu Mizuhara, Haruna Iwaoka, Ball Evelyn, Hiroshi Inami, Tsuyoshi Mizutani, Junko Watanabe, Hiroyuki Usuda, Shinya Nagashima, Tomonori Ito, Toru Kontani, Yasuaki Shimizu and Seitaro Mutoh, Astellas Pharma Inc., Tsukuba, Japan
MicroRNA-15a Regulates Etk/BMX Expression and IL-6 Release In Activated Rheumatoid Synoviocytes
Ghada Alsaleh1, Lucas Philippe1, Angélique Pichot1, Sébastien Pfeffer2, Jacques-Eric Gottenberg1, Jean Sibilia1, Philippe Georgel3 and Dominique Wachsmann1, 1EA4438 Laboratoire Physiopathologie des Arthrites, Illkirch-Strasbourg, France, 2Architecture et Réactivité de l'ARN, Université de Strasbourg, Strasbourg, France, 3Laboratoire d'ImmunoGénétique Moléculaire Humaine, Strasbourg, France
Vimentin Suppresses the Production of Reactive Oxygen Species and the Antimicrobial Response Via p47phox
Nirit Mor-Vaknin, Maureen Legendre, Yue Yu, Carlos H.C. Serezani, Sanjay Garg, Anna Jatzek, Michael D. Swanson, Seagal Teitz-Tennenbaum, Antonello Punturieri, N. Cary Engleberg, Ruma Banerjee, Marc Peters-Golden and David Markovitz, University of Michigan, Ann Arbor, MI
SNAPIN Is Overexpressed in Rheumatoid Arthritis Synovial Tissue and Involved in Endosomal Lysosomal Pathway
Bo Shi1, Qi Quan Huang1, Andrea Dorfleutner1, Christian Stehlik1, Paul P. Tak2 and Richard M. Pope1, 1Northwestern University, Feinberg School of Medicine, Chicago, IL, 2Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam The Netherlands, Amsterdam, Netherlands
Mechanisms of Human Monocytes and Macrophages to Adapt to Hypoxia
Monique Fangradt1, Timo Gaber1, Martin Hahne1, Paula Hoff1, Manuela Jakstadt1, Cindy Strehl1, Gerd-Rüdiger Burmester2 and Frank Buttgereit1, 1Charité University Medicine, Berlin, Germany, 2Charité University Hospital, Berlin, Germany
Ly-6Chigh Monocytes Are Key Cells in Pathogenesis of Autoimmune Arthritis and May Be An Interesting Target for Immunotherapy
Jessy Presumey1, Gabriel Courties1, Virginie Escriou2, Daniel Scherman2, Diego Kyburz3, Steffen Gay4, Yves-Marie Pers5, Christian Jorgensen5 and Florence Apparailly1, 1Inserm, Montpellier, France, 2Inserm, Paris, France, 3University hospital of Zurich, Zurich, Switzerland, 4University Hospital of Zürich, Zürich, Switzerland, 5CHU Lapeyronie, Montpellier, France
Expression of Caspase 8 in Dendritic Cells Is More Potent Than in Myeloid Cells in the Prevention of SLE-Like Disease Onset
Carla M. Cuda1, Jaime Chowaniec1, Jack Hutcheson2, G. Kenneth Haines III3, Chandra Mohan2 and Harris R. Perlman4, 1Northwestern University Feinberg School of Medicine, Chicago, IL, 2University of Texas Southwestern Medical Center, Dallas, TX, 3Yale University, New Harven, CT, 4Northwestern University, Chicago, IL
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