Innate Immunity and Rheumatic Disease

Session Type: ACR Abstract Submissions
Sunday, November 6, 2011: 4:30 PM-6:00 PM
W474a (McCormick Place West)
Moderators: Richard M. Pope, MD, Northwestern Univ Med School and Susan A. Boackle, MD, University of Colorado Denver School of Medicine
4:45 PM
4:45 PM
Circulating Mitochondrial DNA Copy Numbers As a Disease and Activity Marker in ANCA-Associated Vasculitis
Ulrich A. Walker1, Nora M. Effelsberg2, Nils Venhoff3, Chingching Foocharoen1, Jens Thiel3, Paul Hasler4 and Dirk Lebrecht3, 1University of Basel, Basel, Switzerland, 2Dept. of Rheumatology and Centre of Chronic Immunodeficiency, University of Freiburg, Freiburg, Germany, Freiburg, Germany, 3Dpt. of Rheumatology and Center of Chronic Immunodeficiency, University of Freiburg, Freiburg, Germany, Freiburg, Germany, 4Dept. of Rheumatology, Kantonsspital Aarau, Aarau, Switzerland, Aarau, Switzerland
5:00 PM
Active involvement of “alarmins” S100A8 and A9 in regulation of Synovial Activation and Joint Destruction During Mouse and Human Osteoarthritis
Peter Van Lent1, Arjen Blom1, Rik Schelbergen1, Annet Sloetjes1, Thomas Vogl2, Johannes Roth2, Wim B. Van Den Berg1 and and The NOAC study group3, 1Radboud University Nijmegen Medical Center, Nijmegen, Netherlands, 2University of Munster, Munster, Germany, 3Maartens Clinic, Nijmegen, Netherlands
5:15 PM
Soluble CD14 in Synovial Fluid From Patients with Early-Stage Osteoarthritis Augments Synoviocyte Responses to TLR-2 and TLR-4 Ligands
Anjali Nair1, Veero Kanda1, Charles Bush-Joseph1, Nikhil Verma1, Susanna Chubinskaya1, Katalin Mikecz1, Tibor T. Glant1, Anne-Marie Malfait1, Mary K. Crow2, Greg Spear1, Alison Finnegan1 and Carla R. Scanzello1, 1Rush University Medical Center, Chicago, IL, 2Hospital for Special Surgery, New York, NY
5:30 PM
Abatacept (CTLA-4Ig) Treatment Reduces Adhesion and Migratory Capacity of Monocytes in Patients with Rheumatoid Arthritis (RA)
Michael Bonelli1, Elisabeth Ferner1, Anastasiya Hladik1, Lisa Goeschl1, Thomas Karonitsch1, Hans Peter Kiener1, Stefan Blueml1, Carl-Walter Steiner1, Michael Bergmann1, Josef Smolen2 and Clemens Scheinecker1, 1Medical University of Vienna, Vienna, Austria, 2Medical University of Vienna and Hietzing Hospital, Vienna, Austria
5:45 PM
A Novel Autoinflammatory Syndrome Presenting with Chronic Atypical Neutrophilic Dermatitis, Lipodystrophy and Elevated Temperatures (CANDLE syndrome) Caused by Mutation in the Immunoproteasome
Yin Liu1, Yongqing Chen1, Yuval Ramot2, Damaris Garcia1, Antonio Torrelo3, Afzal Sheikh4, Amy Paller5, Adam Reinhardt6, Deborah Stone1, Massimo Gadina7, Plass1 Plass1, Dawn Chapelle1, Zlotogorski Zlotogorski2 and Raphaela T. Goldbach-Mansky8, 1Translational Autoinflammatory Disease Section, Office of the Clinical Director NIAMS, Bethesda, MD, 2Department of Dermatology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel., Jerusalem, Israel, 3Departments of Pediatric Dermatology, Hospital Niño Jesús, Madrid, Spain, Madrid, Spain, 4Medical Genetics Branch, NHGRI, Bethesda, MD, 5Departments of Dermatology and Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA;, Chicago, IL, 6Faculty of Physicians of the University of Nebraska Medical Center, College of Medicine, Nebraska, 7NIAMS, Bethesda, MD, 8NIH Building 10 Room 6D47B, Bethesda, MD
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