Rheumatoid Arthritis - Human Etiology and Pathogenesis II: Pathogenesis of Rheumatoid Arthritis - What's New?

Session Type: ACR Abstract Submissions
Tuesday, November 8, 2011: 4:30 PM-6:00 PM
W196a (McCormick Place West)
Moderators: Kris Reedquist, PhD, Academic Medical Center, University of Amsterdam and Maripat Corr, MD, Univ of California-San Diego
4:30 PM
Unique DNA Methylome Signature in Rheumatoid Arthritis (RA)
Kazuhisa Nakano1, John Whitaker2, Wei Wang3, David L. Boyle2 and Gary S. Firestein2, 1University of Occupational and Environmental Health, Japan, Kitakyushu, Japan, 2UCSD School of Medicine, La Jolla, CA, 3UCSD, La Jolla, CA
4:45 PM
A Distinctive Oral Microbiome Characterizes Periodontitis in Patients with Early Rheumatoid Arthritis
Jose U. Scher*1, Carles Ubeda*2, Walter Bretz3, Michael H. Pillinger1, Yvonne Buischi3, Pamela B. Rosenthal4, Soumya M. Reddy1, Jonathan Samuels1, Peter M. Izmirly4, Gary E. Solomon1, Mukundan Attur1, Michele Equinda2, Nicholas Socci2, Agnes Viale2, Gerald Weissmann4, Dan R. Littman4, Eric G. Pamer2 and Steven B. Abramson1, 1NYU Hospital for Joint Diseases, New York, NY, 2Memorial Sloan-Kettering Cancer Center, The Lucille Castori Center for Microbes, Inflammation and Cancer, New York, NY, 3NYU College of Dentistry, New York, NY, 4NYU School of Medicine, New York, NY
5:00 PM
MiR-196a Is An Important Regulator of Synovial Fibroblasts In the Pathogenesis of Rheumatoid Arthritis
Maria Filkova1, Michelle Trenkmann1, Joanna Stanczyk1, Mojca Frank1, Christoph Kolling2, Lars C. Huber3, Beat A. Michel1, Renate E. Gay1, Ladislav Senolt4, Steffen Gay1 and Astrid Jüngel1, 1Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, 2Schultess Clinic, Zurich, Switzerland, 3Clinic and Policlinic for Internal Medicine, University Hospital Zurich, Switzerland, Zurich, Switzerland, 4Institute of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
5:15 PM
Epigenome Analysis Reveals TBX-5 As a Novel Transcription Factor Involved in the Activation of Rheumatoid Arthritis Synovial Fibroblasts
Emmanuel Karouzakis1, Michelle Trenkmann1, Caroline Ospelt1, Christoph Kolling2, Renate E. Gay1, Beat A. Michel1, Steffen Gay1 and Michel Neidhart1, 1Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, 2Schultess Clinic, Zurich, Switzerland
5:30 PM
9G4 Expression on Antibodies to Citrullinated Residues in Patients with Early Inflammatory Arthritis and Established Rheumatoid Arthritis
Rita A. Moura1, Inmaculada de la Torre2, Maria J. Leandro3, Jonathan CW Edwards3 and Geraldine Cambridge4, 1Rheumatology Research Unit, Instituto de Medicina Molecular, Lisbon, Portugal, Lisbon, Portugal, 2Gregorio Marańón Hospital, Madrid, Spain, 3UCL, London, United Kingdom, 4University College London, London, United Kingdom
5:45 PM
Heightened Immune Response to Autocitrullinated Porphyromonas Gingivalis Peptidylarginine Deiminase Is a Potential Mechanism for Breaching Immunologic Tolerance in Rheumatoid Arthritis
Anne-Marie Quirke1, Natalia Wegner1, Bart Hamilton2, Peter J. Charles3, Muslima Chowdhury1, Elena B. Lugli1, Jan Potempa4, Geoffrey M. Thiele5, Ted R. Mikuls6 and Patrick Venables7, 1Imperial College London, London, United Kingdom, 2University of Nebraska Medical Centre and Omaha VA Medical Center, Omaha, 3Charing Cross Hospital, London, United Kingdom, 4Jagiellonian University, Krakow, Poland, 5Univ of Nebraska Med Ctr, Omaha, NE, 6Omaha VA and University of Nebraska, Omaha, NE, 7Kennedy Institute, London, United Kingdom
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