B-cell Biology and Targets in Autoimmune Disease

Session Type: ACR Abstract Submissions
Tuesday, November 8, 2011: 4:30 PM-6:00 PM
W475a (McCormick Place West)
Moderators: William Stohl, MD, PhD, University of Southern California Keck School of Medicine and Jennifer H. Anolik, MD, PhD, University of Rochester
4:30 PM
Effective Anti-CD20 Therapy for Arthritis Is Associated with B-Cell Depletion in Efferent Lymph Nodes and Increased Lymph and Cellular Flow in Lymphatic Vessels From Arthritic Joints
Jie Li1, Christopher T. Ritchlin2, Ignacio Sanz1, Andrea Bottaro1, Ronald Wood1, Lianping Xing1 and Edward M. Schwarz1, 1University of Rochester School of Medicine and Dentistry, Rochester, NY, 2University of Rochester Medical Center, Rochester, NY
4:45 PM
A Whole-Blood Transcriptomic Signature Predicts Clinical Response to Rituximab in Rheumatoid Arthritis
Jeremie Sellam1, Sandrine Marion-Thore2, F. Dumont2, Franck Letourneur3, Stephanie Rouanet4, Yassine Taoufik5, Jean Sibilia6, Jacques G. Tebib7, Xavier Le Loët8, Bernard G. Combe9, Maxime Dougados10, Xavier Mariette11 and Gilles Chiocchia3, 1Hopital Saint-Antoine, Pierre et Marie Curie University Paris 6, AP-HP, 75012, France, 2INSERM U1016, Institut Cochin, Paris Descartes University, Paris, France, 3Institut Cochin, 75014 Paris, France, 4Roche, Neuilly sur Seine, France, 5Hopital Bicetre, Université Paris Sud, AP-HP, France, 6Service de rhumatologie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France, Strasbourg, France, 7Centre Hosp Lyon Sud, Pierre Benite, France, 8Department of Rheumatology, Rouen University Hospital & Inserm 905, Institute for Biomedical Research, University of Rouen, Rouen, France, 9Hopital Lapeyronie, Montpellier, France, 10Paris-Descartes University, Paris, France, 11Université Paris-Sud, Le Kremlin Bicetre, France
5:00 PM
A Humanized Monoclonal Antibody Against a Surface Ligand of Mononuclear Cells Suppress Autoimmune Inflammatory Diseases by Upregulation of IL-10 Secretion
Yaakov Naparstek, Rina Ulmansky, Galia Katzavian, Ronit Meyuhas, Alon Hershko, Eli Moallem, Shira Yair and Dorit Landstein, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
5:15 PM
B Cells Enhance the Type I Interferon Production by Plasmacytoid Dendritic Cells Via CD31
Lars Rönnblom1, Olof Berggren1, Gert Weber2, Niklas Hagberg1 and Maija-Leena Eloranta1, 1Section of Rheumatology, Uppsala University, Uppsala, Sweden, 2Structural Biochemistry, Free University of Berlin, Berlin, Germany
5:30 PM
The Critical Role of Protein Kinase C Beta in Lupus Development in Lupus Mice
Luojing Chen, University of Rochester, Rochester, NY
5:45 PM
Effect of Intravenous Cyclophosphamide Treatment on B Cells in SLE Nephritis
Chungwen Wei1, John Jung1, Valentin Marian1, Donna F. Hardwick2, Gema Souto-Adeva3, Youqun Huang1, Bridget Neary1, Gabor G. Illei3 and Ińaki Sanz1, 1University of Rochester, Rochester, NY, 2NIH MSC 1616, Bethesda, MD, 3NIDCR/ NIH #10 1N110, Bethesda, MD
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