B-cell Biology and Targets in Autoimmune Disease

Session Type: ACR Abstract Submissions
Tuesday, November 8, 2011: 9:00 AM-6:00 PM
Hall F2 - Poster Hall (McCormick Place West)
Papers:
Reduced Imprints of Receptor Editing At the Immunologlobulin κ and λ Light Chain Loci During Rituximab Treatment
Khalid Muhammad1, Arumugam Palanichamy1, Petra Roll1, Stefan Kleinert1, Thomas Dörner2 and Hans-Peter Tony1, 1University of Würzburg, Würzburg, Germany, 2Charite Universitätsmedizin Berlin and DRFZ, Berlin, Germany
The Levels of Memory B-Cells with a Plasmablast-Like Phenotype Are Associated with Response to Anti-CD20 Treatment in Rheumatoid Arthritis
Gururaj Arumugakani1, Andrew Rawstron2, Reuben Tooze1, Paul Emery3 and Dennis McGonagle4, 1University of Leeds, Leeds, United Kingdom, 2NIHR Leeds Biomedical Research Unit, University of Leeds and Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom, 3Chapel Allerton Hospital, Leeds, United Kingdom, 4University of Leeds and Leeds Teaching Hospitals, Leeds, United Kingdom
B Cell Depletion Therapy After Multiple Cycles of  Rituximab in Patients with Rheumatoid Arthritis: B Cell and Plasma Cell Dynamics Measured Using Serology
Geraldine Cambridge1, Maria J. Leandro1, Jonathan CW Edwards1, Harvey M. Parsons1, Marion C. Dickson2 and Hayley Perry2, 1UCL, London, United Kingdom, 2GSK, Stevenage
Value of Predictive B Cell Markers for EULAR Response to RITUXIMAB in Patients with Rheumatoid Arthritis (FIRST)
Hans-Peter Tony1, Petra Roll1, Henrik Mei2, Lara Gnuegge3, Monika Kobialko3, Thomas Dörner4 and FIRST study team5, 1University of Würzburg, Würzburg, Germany, 2Charite Universitätsmedizin Berlin and DRFZ,, 10117 Berlin, Germany, 3Roche Pharma AG, 79639 Grenzach-Wyhlen, Germany, 4Charite Universitätsmedizin Berlin and DRFZ,, Berlin,, Germany, 5Würzburg
B Cell Activating Factor (BAFF) Binding Receptors (BBR) on B Cells: Characterization in Patients with Rheumatoid Arthritis (RA) Receiving B Cell Depletion Therapy (BCDT) Based on Rituximab ( Rtx)
Elena Becerra-Fernandez1, Inmaculada de la Torre2, Lara Valor2, Maria J. Leandro1 and Geraldine Cambridge1, 1UCL, London, United Kingdom, 2Gregorio Marañón Hospital, Madrid, Spain
No Expression of An Alternative CD20 Transcript Variant in B Cells From Patients with Rheumatoid Arthritis
Marina Deschamp1, Béatrice Gaugler1, Philippe Saas1, Christophe Ferrand1 and Eric Toussirot2, 1INSERM UMR645 - IFR 133, Besançon, 2Rheumatology and CIC Biotherapy 506 and EA 4266 Pathogens and Inflammation, Besançon, France
B Cell Function and Cytokine Secretion After B Cell Depletion Therapy in SLE and RA
Arumugam Palanichamy, James Roger, Wensheng Wang, Jennifer Barnard, Jamie Biear, Chungwen Wei, Iñaki Sanz and Jennifer H. Anolik, University of Rochester, Rochester, NY
Rituximab for the Treatment of IgG4-Related Disease:Lessons From Ten Consecutive Patients
Arezou Khosroshahi, Mollie Carruthers, Vikram Deshpande, Sebastian Unizony, Donald B. Bloch and John H. Stone, Massachusetts General Hospital, Boston, MA
Antibody Secreting Cells Arising After Vaccination From Anti-Cardiolipin Positive Individuals Can Produce Antibodies Which Are Bi-Specific and Bind to Both Cardiolipin and the Vaccinating Antigen
Kenneth Smith1, Jennifer Muther1, Angie Duke1, Emily McKee1, Patrick C. Wilson2 and Judith A. James3, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2University of Chicago, Chicago, IL, 3Oklahoma Medical Research Foundation and Oklahoma University Health Sciences Center, Oklahoma City, OK
Epratuzumab Inhibits Upstream B Cell Receptor Signaling and Modulates Ca2+ Flux Upon Activation
N. Sieger1, K. Reiter1, H.E. Mei1, T. Shock2, C. Daridon1 and T. Dörner1, 1Charité University Medicine Berlin, Berlin, Germany, 2UCB, Slough, United Kingdom
PTPN22 Risk Allele Interferes with the Removal of Developing Autoreactive B Cells in Humans
David Saadoun1, Laurence Menard2, Isabelle Isnardi2, Yen-shing Ng3, Greta Meyers2, Clara Abraham4, Roja Moyaghedi5, Jane Buckner6, Peter K. Gregersen7 and Eric Meffre8, 1Department of Internal Medicine and Laboratory I3 “Immunology, Immunopathology, Immunotherapy”, UMR CNRS 7211, INSERM U959, Groupe Hospitalier Pitié-Salpetrière, Université Pierre et Marie Curie, Paris 6, Paris, France, Paris, France, 2Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06511, USA;, New haven, 3Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06511, USA;, New Haven, 4Department of Medicine, Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT 06509, USA,, New Haven, 5Department of Pediatrics, Weill Medical College of Cornell University, New York, NY 10021, USA,, New York, 6Translational Research Program, Benaroya Research Institute, Seattle, WA 98101, USA,, Seattle, 7Feinstein Institute Medical Reschearch, Manhasset, NY, 8Yale University School of Medicine, New Haven, CT
Syk Inhibition with Fostamatinib Leads to Transitional B Lymphocyte Depletion
Chungwen Wei, Paul M. Barr, Julia Schaefer-Cutillo, John Jung, James Roger, Jennifer L. Kelly, Alex Rosenberg, Jonathan W. Friedberg and Iñaki Sanz, University of Rochester, Rochester, NY
Carbamoylation of Vimentin in Patients with Rheumatoid Arthritis: Identification of a Novel Protein Modification with a Possible Link to Disease Pathogenesis
Holger Bang1, Karl Egerer2, Anette Krämer1, Eugen Feist2 and Gerd R. Burmester2, 1Orgentec Diagnostika GmbH, Mainz, Germany, 2Charité - Universitätsmedizin Berlin, Berlin, Germany
Early Rheumatoid Arthritis (ERA) Has Lower Levels of Plasmablasts and Memory B Cells Compared to Long-Standing RA (LSRA) and Responds to Conventional Therapy with a Normalization of  B Cell Subsets Abnormalities
Anna Laura Fedele, Barbara Tolusso, Silvia L. Bosello, Silvia Canestri, Elisa Gremese and Gianfranco Ferraccioli, Division of Rheumatology, Catholic University of the Sacred Heart, Rome, Italy
Identification of Autoantibody Profiles by Monitoring Autoantibody Biomarkers in RA with Microarray Surface Plasmon Resonance Imaging
Joyce J.B.C. Van Beers1, Angelique M.C. Segbers-Lokate1, Wilma T.M. Vree Egberts1, Richard B.M. Schasfoort2 and Ger J.M. Pruijn1, 1Radboud University Nijmegen, Nijmegen, Netherlands, 2University of Twente and IBIS Technologies BV, Enschede, Netherlands
Development of a High-Throughput, Multiplex Assay for Profiling the Autoantibody Fine Specificity in Rheumatoid Arthritis
Xiaoyan Zhao1, P. Scott Eastman1, Ferhan Qureshi1, William C. Manning1, William Robinson2 and Lyndal K. Hesterberg1, 1Crescendo Bioscience, Inc., South San Francisco, CA, 2Stanford Univ School of Med, Stanford, CA
Anti-hnRNP Autoantibodies Detected in Inflammatory Rheumatic Diseases in Use to Close the Sensitivity gap  left  by Rheumatoid Factor and Anti CCP in Early RA
Bianka Marklein1, Zoltan Konthur2, Gerd-Rüdiger Burmester3 and Karl Skriner1, 1Charité - Universitätsmedizin Berlin, Berlin, Germany, 2Max Planck Institute for Molecular Genetics, Berlin, Germany, 3Charité - University Medicine Berlin, Berlin, Germany
Substantial Influence of Rheumatoid Factor Positivity On the Peripheral Memory B Cells and Its Modulation by TNF Inhibition In RA
Petra Roll1, Khalid Muhammad1, Mathias Schumann1, Stefan Kleinert2 and Hans-Peter Tony1, 1University of Würzburg, Würzburg, Germany, 2Rheumatology, University of Würzburg, Würzburg, Germany
Dynamic Evolution of a Public Clonotypic Autoantibody Specific for Ro60: Perpetuating Humoral Autoimmunity Through Clonotypic Shift
Rhianna Lindop1, Georgia Arentz1, Tim, K. Chataway2, Lauren A. Thurgood1, Michael W. Jackson1 and Tom P. Gordon1, 1Flinders Medical Centre and Flinders University, Adelaide, Australia, 2Flinders University, Adelaide, Australia
APRIL and BAFF Levels After Rituximab Treatment in Patients with Primary Sjögren’s Syndrome: A Placebo-Controlled Clinical Trial
Rodney Pollard, Wayel H. Abdulahad, Minke G. Huitema, Annie Visser, Jiska Meijer, Hans Burgerhof, Fred Spijkervet, Cees GM Kallenberg, Arjan Vissink, Frans Kroese and Hendrika Bootsma, University Medical Center Groningen, Groningen, Netherlands
Expansion of Functionally Anergic Autoreactive CD21-/Low Marginal Zone B Cell Clones in Hepatitis C Virus Infection-Related Autoimmunity
Benjamin Terrier1, Florence Joly2, Philippe Benech2, Michelle Rosenzwajg3, Wassila Carpentier4, Pascale Ghillani-Dalbin5, David Klatzmann3, Patrice Cacoub5 and David Saadoun6, 1Pitié-Salpêtrière Hospital, Paris, France, 2Prediguard, Marseille, France, 3Laboratory I3 “Immunology, Immunopathology, Immunotherapy”, UMR CNRS 7211, INSERM U959, Paris, France, 4Plateforme génomique P3S, Paris, France, 5CHU Pitié-Salpêtrière, Paris, France, 6Department of Internal Medicine and Laboratory I3 “Immunology, Immunopathology, Immunotherapy”, UMR CNRS 7211, INSERM U959, Groupe Hospitalier Pitié-Salpetrière, Université Pierre et Marie Curie, Paris 6, Paris, France, Paris, France
The Sympathetic Neurotransmitter Norepinephrine Inhibits Proinflammatory IL-7-Receptor Alpha Positive B Cells in Arthritis
Georg Pongratz, Judith Anthofer, Madlen Melzer and Rainer H. Straub, University Hospital Regensburg, Regensburg, Germany
Arthritogenic T Cells Regulate the Homeostatic Expansion of Antigen-Specific B Cells, and These B Cells or Antibodies Are Essential for the Development of Arthritis
Katalin Kis-Toth1, Marianna Radacs2, Tamas Kobezda3, Willem van Eden4, Katalin Mikecz3 and Tibor T. Glant3, 1Boston, MA, 2Szegedi Tudomany Egyetem: JGYPK, Szeged, Hungary, 3Rush University Medical Center, Chicago, IL, 4Utrecht,, Netherlands
FasL+ Regulatory B Cells Are Expanded by Interleukin-5 and Induce Apoptosis in CD4+ T Cells Via Cell-Cell Contact and Secretion of FasL+ Exosomes
Matthew W. Klinker, Brian Alzua, Tamra Reed, Campbell Shaw, David A. Fox and Steven K. Lundy, University of Michigan, Ann Arbor, MI
Translational Medicine of a Selective Inhibitor of Btk in Rheumatic Diseases: Pharmacology and Early Clinical Development
Erica Evans, Richland Tester, Sharon Aslanian, Prasoon Chaturvedi, Russell Karp, Matt Labenski, Hormoz Mazdiyasni, Mariana Nacht, Michael Sheets, Kathryn Stiede, Steve Witowski, Heather Lounsbury, Russ Petter, Juswinder Singh and William Westlin, Avila Therapeutics, Waltham, MA
A Bruton’s Tyrosine Kinase Inhibitor Prevents Antigen-Driven B Cell Activation In Vivo
Micah Benson1, Varenka A. Rodriguez1, Tatyana Andreyeva1, Sean Keegan1, John R. Springer2, Mark E. Schnute2, Kyri Dunussi-Joannopoulos1, Cheryl L. Nickerson-Nutter1, Andrew L. Rankin1, Melanie Ruzek1 and John Douhan III1, 1Pfizer, Cambridge, MA, 2Pfizer, Inc, Cambridge, MA
IL-10-Producing Regulatory B Cells (B10 cells) Inhibit Intestinal Injury In Mice
Koichi Yanaba and Shinichi Sato, The University of Tokyo, Tokyo, Japan
B Cell Depletion Enhances T Regulatory Activity Essential in the Suppression of Arthritis 
Susan Ashaye, Keith Hamel, Yanxia Cao, Yumei Wang, Tibor T. Glant and Alison Finnegan, Rush University Medical Center, Chicago, IL
Efficient Depletion of Autoreactive Plasma Cells within the Nephritic Kidneys in a Murine Model of SLE by Bortezomib
Charlotte M. Starke1, Vilma Urbonaviciute1, Silke Frey1, Georg Schett2 and Reinhard E. Voll3, 1Clinical Research Group, Nikolaus-Fiebiger Center of Molecular Medicine, Erlangen, Germany, 2University of Erlangen-Nuremberg, Erlangen, Germany, 3Dept. of Rheumatology and Centre of Chronic Immunodeficiency, University of Freiburg, Freiburg, Germany
TLR7 Overexpression Promotes Accumulation of Autoreactive CD19+ CD11c+ B Cells
Alice Wiedeman and Keith B. Elkon, University of Washington, Seattle, WA
Anti-DNA Antibody Production Is Restricted by the Germline Composition of DH Genes
Aaron Silva-Sanchez1, Cunren Liu1, Pratibha Kapoor1, Yingxin Zhuang1, Trenton R. Schoeb1 and Harry W. Schroeder Jr.2, 1University of Alabama at Birmingham, Birmingham, AL, 2University of Alabama-Birmingham, Birmingham, AL
A Novel Method to Evaluate Autoreactivity by Inducing Antibodies Secretion Allows the Study of Tolerance In Mice
Emiliano Marasco1, Nataly Manjarrez Orduño1, Peter K. Gregersen2 and Betty Diamond3, 1Feinstein Institute for Medical Research, Manhasset, NY, 2Feinstein Institute Medical Reschearch, Manhasset, NY, 3Feinstein Institute Med Rsch, Manhasset, NY
Subtoxic Dose of Mercury Reduces Splenic Marginal Zone B Cells, Resulting in the Increase in Autoantibodies in Murine Mercury-Induced Autoimmunity
Takaji Matsutani1, Miho Murakami1, Hooi-Ming Lee2, Hidehiko Sugino2 and Norihiro Nishimoto1, 1Wakayama Medical University, Ibaraki, Japan, 2Osaka University, Suita, Japan
Induction of Regulatory B Cells in Healthy Individuals and Patients with Systemic Lupus Erythematosus
Shun-ichiro Ota, Hiroaki Niiro, Naoko Ueki, Hirofumi Tsuzuki, Siamak Jabbarzadeh-Tabrizi, Yasushi Inoue, Yojiro Arinobu and Koichi Akashi, Kyushu University, Fukuoka, Japan
The Comprehensive B Cell Profiling Analysis of a Multicenter SLE Cohort
John Jung1, Jamie Biear1, Youqun Huang1, Bridget Neary1, Elides Marin1, Jennifer Hossler1, Elise Palmer1, Sharleen Smith1, Ehtisham Akhter2, Tracey Sanford1, Jie Xu2, Michelle Petri2, Alex Rosenberg1, Jennifer H. Anolik1, Chungwen Wei1 and Iñaki Sanz1, 1University of Rochester, Rochester, NY, 2Johns Hopkins University School of Medicine, Baltimore, MD
A Novel Circulating CXCR5-CD20++ B Cell Compartment  in Patients with Systemic Lupus Erythematosus
Eric S. Sobel, Edward Butfiloski, James Hunt, Mark Segal, Laurence Morel, Westley H. Reeves and Minoru Satoh, University of Florida, Gainesville, FL
Effect of Mycophenolat Mofetil (MMF) on Clinical and Paraclinical Parameters in Systemic Lupus Erythematosus (SLE)
Sebastian Eickenberg, Elisabeth Jung, Eva Mickholz and Annett M. Jacobi, University Hospital Münster, Münster, Germany
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