Cytokines, Mediators, and Gene Regulation II

Session Type: ACR Abstract Submissions
Tuesday, November 8, 2011: 4:30 PM-6:00 PM
W193a (McCormick Place West)
Moderators: Harris R. Perlman, PhD, Northwestern University and Kyriakos A. Kirou, MD, Hospital for Special Surgery
4:30 PM
IL-27 Receptor Signaling Is Critical for B Cell Differentiation in Collagen Induced Arthritis
Odilia B.J. Corneth1, Anne-Marie Mus2, Patrick S. Asmawidjaja2, Rudi W. Hendriks2 and Erik Lubberts2, 1Erasmus MC, University Medical Center, Rotterdam, Rotterdam, Netherlands, 2Erasmus MC, University Medical Center, Rotterdam, Netherlands
4:45 PM
Interleukin-27 Receptor-Deficient Mice Develop Exacerbated Inflammatory Arthritis Associated with Heightened T- and B- Cell Responses
Gareth W. Jones1, Anwen S. Williams1, Mari A. Nowell1, Brendan J. Jenkins2 and Simon A. Jones3, 1School of Medicine, Cardiff University, Cardiff, Wales, United Kingdom, 2Monash Institute of Medical Research, Monash University, Melbourne, Australia, 3Cardiff University, Cardiff, United Kingdom
5:00 PM
IL-22 Restrains the Progression to Severe Arthritis
Sujata Sarkar, Xiaoqun Zhou and Swaroopa Bommireddy, University of Arizona, Tucson, AZ
5:15 PM
Interferon-γ and Toll-Like Receptor 9 Collaborate to Cause Both Leukopenia and Anemia In a Murine Model of Macrophage Activation Syndrome by Two Distinct Mechanisms
Katharine Slade1, Scott Canna1, Portia Kreiger2 and Edward M. Behrens1, 1Childrens Hospital of Philadelphia, Philadelphia, PA, 2A.I. DuPont Hospital for Children, Wilmington, DE
5:30 PM
Opposing Regulation of IFN Response Genes and STAT1 in Rheumatoid Arthritis Synovial Fluid Macrophages by TNFß and the Synovial Fluid Microenvironment
Rachael A. Gordon, Galina Grigoriev, George D. Kalliolias and Lionel B. Ivashkiv, Hospital for Special Surgery, New York, NY
5:45 PM
Plasmacytoid Dendritic Cells ináHuman Lupus Bone Marrow Are Primed for Interferon Alpha Production
Sarah Nevarez1, Arumugam Palanichamy1, Alfred Rabinovich1, Jennifer Barnard1, Jamie Biear1, Ben Panepento1, Chungwen Wei1, Christopher T. Ritchlin2, James Kobie1, I˝aki Sanz1 and Jennifer H. Anolik1, 1University of Rochester, Rochester, NY, 2University of Rochester Medical Center, Rochester, NY
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