Cytokines, Mediators, and Gene Regulation

Session Type: ACR Abstract Submissions
Sunday, November 6, 2011: 9:00 AM-6:00 PM
Hall F2 - Poster Hall (McCormick Place West)
Papers:
Epigenetically Regulated MicroRNA-126 Influences Migratory Potential and Apoptosis of Synovial Fibroblasts in Rheumatoid Arthritis
Mojca Frank1, Maria Filkova1, Joanna Stanczyk1, Mary Connolly1, Christoph Kolling2, Beat A. Michel1, Blaz Rozman3, Renate E. Gay1, Steffen Gay1 and Astrid Jungel1, 1Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, 2Schultess Clinic, Zurich, Switzerland, 3University Medical Centre, Ljubljana, Slovenia
Mathematical Modeling of Interleukin-6 Signaling Inhibition: Comparative Efficiency of Different Intervention Strategies
Saroja Ramanujan1, Daniel Young1, Peter Maisonpierre1, Stevan Shaw2, Jason Chan1 and Kosmas Kretsos2, 1Entelos, Inc., Foster City, CA, 2UCB, Slough, United Kingdom
Abnormalities in a JAK-STAT Pathway Are Involved in the Aberrant Production of IL-6 by BAFF-Stimulated Peripheral Monocytes of Patients with Primary Sjögren’s Syndrome
Keiko Yoshimoto1, Maiko Tanaka1, Masako Kojuma1, Hideko Ogata1, Hideto Kameda1, Tohru Abe2 and Tsutomu Takeuchi1, 1Keio University School of Medicine, Tokyo, Japan, 2Saitama Medical School, Kawagoe-shi Saitama, Japan
MiR-451 in Microparticles Derived From Monocytes Influences Gene Expression in Rheumatoid Arthritis Synovial Fibroblasts
Meike Dahlhaus1, Joanna Stanczyk1, Mojca Frank1, Beat A. Michel1, Christoph Kolling2, David S. Pisetsky3, Renate E. Gay1, Steffen Gay1, Astrid Jüngel1 and Diego Kyburz1, 1Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, 2Schultess Clinic, Zurich, Switzerland, 3Duke University Medical Center, Durham, NC
The Influence of Cigarette Smoke on Expression of Histone Deacetylases in Rheumatoid Arthritis
Anna Loeffler1, Peter Kunzler1, Fabienne Niederer1, Astrid Jungel1, Christoph Kolling2, Giovanni Camici3, Beat A. Michel4, Renate E. Gay1, Steffen Gay1 and Caroline Ospelt1, 1Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, 2Schultess Clinic, Zurich, Switzerland, 3Institute of Physiology, University of Zurich, Switzerland, 4University Hospital, Zurich, Switzerland
A-SAA Induced Angiogenesis and Endothelial Cell Invasion Is Mediated Through NOTCH Signalling Pathways
Peter Rooney1, Mary Connolly2, Wei Gao3, Douglas J. Veale4 and Ursula Fearon4, 1University College Dublin, Dublin, Ireland, 2Center of Experimental Rheumatology, University Hospital Zürich, Zurich, Switzerland, 3St. Vincent's University Hospital, Dublin, Ireland, 4Dublin Academic Medical Centre, University College Dublin, Dublin, Ireland
Age-Related Mitochondrial Dysfunction Sensitizes Human Synoviocytes to Inflammatory Response
M. Noa Valcárcel-Ares1, Romina R. Riveiro-Naveira1, Carlos Vaamonde-García1, Laura Hermida-Carballo1, Francisco J. Blanco2 and Maria J. López-Armada1, 1Aging and Inflammation Research Lab, INIBIC-CHU A Coruña, A Coruña, Spain, 2Osteoarticular and Aging Research Lab, INIBIC-CHU A Coruña, A Coruña, Spain
Regulatory and Anti-Inflammatory Effects of MAP Kinase Phosphatase-1 in Inflammation and Arthritis
Riku Korhonen1, Riina Nieminen1, Tuija Turpeinen1, Ville Taimi1, Antonis Goulas2, Andrew R. Clark3 and Eeva Moilanen1, 1University of Tampere School of Medicine and Tampere University Hospital, Tampere, Finland, 2Aristotle University of Thessaloniki, Greece, 3Imperial College London, London, United Kingdom
Critical Role for the IL-23/TNF Axis During TLR2/NOD2 Mediated Acute Joint Inflammation
Ferry Cornelissen1, Odilia B.J. Corneth2, Anne-Marie Mus1, Patrick S. Asmawidjaja1 and Erik Lubberts1, 1Erasmus MC, University Medical Center, Rotterdam, Netherlands, 2Erasmus MC, University Medical Center, Rotterdam, Rotterdam, Netherlands
T-Cell-Related Cytokines Are Inhibited in Response to Tocilizumab in Patients with Rheumatoid Arthritis in Contrast with TNF-Inhibitor
Jiro Yamana1, Mitsuyoshi Iwahashi2, Motoaki Kim1, Rie Sasaki1, Keisuke Kobayashi1, Seizo Yamana1, Yusuke Sasaki3, Yasushi Shimonaka3 and Masahiko Mihara4, 1Higashi-hiroshima memorial Hospital, Hiroshima, Japan, 2Higashi-Hiroshima Memorial Hospital, Higashi-hiroshima, Japan, 3Chugai Pharmaceutical Co., Ltd., Kamakura, Kanagawa, Japan, 4Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan
Increased Plasma Levels of IL17F in Rheumatoid Arthritis Patients Are Reduced by Methotrexate and Biologic Agents
Jeffrey D. Greenberg1, Victoria Furer1, John Todd2, Quynh Ann Lu2, Renita Ramirez2, Michael Lock2, Steven B. Abramson1 and Mukundan Attur1, 1NYU Hospital for Joint Diseases, New York, NY, 2Singulex, Alameda, California, Alameda, CA
Decrease of Serum IL-35 Predicts Clinical Improvement in Patients with Very Early RA
Ladislav Senolt1, Mária Filková1, Hana Hulejová1, Lucie Andrés Cerezo1, Ondrej Pecha2, Lenka Plestilová1, Katerina Jarosova1, Karel Pavelka1, Jiri Vencovsky1 and Herman F. Mann1, 1Institute of Rheumatology, Department of Clinical and Experimental Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic, 2Institute of Biophysics and Informatics, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
Vitamin D Deficient Healthy Individuals Have Decreased Activated T Cells and Altered Lymphocyte Responses to Cytokine Stimulation
Lauren L. Ritterhouse1, Holden T. Maecker2, Hongwu Du3, C. Garrison Fathman4, Joel Guthridge1 and Judith A. James5, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2University School of Medicine, Stanford, CA, 3Stanford University School of Medicine, Stanford, CA, 4Stanford Univ Medical Center, Stanford, CA, 5Oklahoma Medical Research Foundation and Oklahoma University Health Sciences Center, Oklahoma City, OK
Hypoxia and Inflammation Synergistically Promote Bone Destruction
Shankar Revu1, Vivekananda Sunkari2, Akilan Krishnamurthy3, Ileana R. Botusan2, Sergiu-Bogdan Catrina2 and Anca Irinel Catrina4, 1Rheumatology unit, Stockholm, Sweden, 2Stockholm, Sweden, 3Karolinska Institute, Karolinska University Hospital, Solna, Stockholm, Sweden, 4D2:01, Stockholm, Sweden
Anti-TNF Therapy Sensitizes RA Monocytes to TRAIL-Induced Apoptosis Via Inhibition of Pro-Survival Effects of Soluble TNF
Undine Meusch1, Manuela Rossol2, Dagmar Quandt1, Christoph G. Baerwald3 and Ulf Wagner1, 1University of Leipzig, Leipzig, Germany, 2Translationszentrum für Regenerative Medizin (TRM), University of Leipzig, Leipzig, Germany, 3University Hospital, Leipzig, Germany
Regulation of Suppressor of Cytokine Signaling-1, -2 and -3 Expression in Patients with Early Arthritis
Ricardo J. Villares1, Amalia Lamana2, Coloma Costas1, Ana M. Ortiz2, Mercedes López-Santalla1, Mario Mellado1 and Isidoro González-Alvaro2, 1Centro Nacional de Biotecnología. CNIC, Madrid, Spain, 2Hospital Universitario de La Princesa. IIS Princesa, Madrid, Spain
Expression Levels of Interleukin-17A, Interleukin-17F and Their Receptors in Synovium of Patients with Rheumatoid Arthritis, Psoriatic Arthritis and Osteoarthritis: A Target Validation Study
Lisa G.M. van Baarsen, Maria C. Lebre, Dennis van der Coelen, Danielle M. Gerlag and PP. Tak, Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
Type I Interferon and Clinical Phenotype in Idiopathic Inflammatory Myopathies
Louise Ekholm1, Anna Tjärnlund1, Clio P. Mavragani2, Peter J. Charles3, Leonid Padyukov1, Mary K. Crow4 and Ingrid E. Lundberg5, 1Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Solna, Karolinska Institutet, Stockholm, Sweden, 2Department of Experimental Physiology, School of Medicine, University of Athens, Athens, Greece, 3Kennedy Institute of Rheumatology, Imperial College, London, United Kingdom, 4Hospital for Special Surgery, New York, NY, 5Karolinska Institutet, Stockholm, Sweden
Comparative Cytokine Analysis Across a Spectrum of Genetically and/or Clinically Defined Auto-Inflammatory Syndromes
Apostolos Kontzias1, Yongqing Chen1, Nicole Plass1, Damaris Garcia1, Elizabeth Joyal1, Robert Wesley2 and Raphaela T. Goldbach-Mansky1, 1National Institutes of Health Clinical Center, Bethesda, MD, 2National Insitutes of Health Clinical Center, Bethesda, MD
PGE2 and FGF-2 Upregulate Activities of the Human F-Spondin Promoter
Mukundan Attur1, Yang Qing2, Jinhua Wang3, Kimberlee Mix4, Glyn Palmer1 and Steven B. Abramson1, 1NYU Hospital for Joint Diseases, New York, NY, 2New York University School of Medicine, New York, NY, 3New York University Cancer Institute, New York, NY, 4Loyola University New Orleans, New Orleans, LA
Correlation of Vascular Endothelial Growth Factor and Interleukin-6 Levels with Power Doppler Ultrasound of Synovial Joints in Early Inflammatory Arthritis
Joanne Kitchen, Adelaide and Meath Hospital, Dublin, Ireland and David Kane, Adelaide, Meath hospital Dublin (incorporating the National Children's hospital), Dublin 24, Ireland
Preferential Inhibition of IL-6 TRANS-Signaling Shows Potent Anti-Inflammatory Activity In Vivo: The Potential of NI-1201, a Novel Fully Human IL-6R Monoclonal Antibody
Florence Guilhot1, Vanessa Buatois1, Laurence Chatel1, Laura Cons1, Eric Hatterer1, Greg Elson1, Suzanne Herren1, Giovanni Magistrelli1, Pauline Malinge1, Simon Jones2, Manuela Gabler3, Thomas Kamradt3, Cristina de Min1, Marie Kosco-Vilbois1 and Walter Ferlin1, 1NovImmune S.A., Plan-Les-Ouates, Geneva, Switzerland, 2Cardiff University, Cardiff, United Kingdom, 3Institute of Immunology, Jena University Hospital, Jena, Germany
Interleukin-22 Promotes Osteoclastogenesis in Rheumatoid Arthritis Through Induction of Receptor Activator of Nuclear Factor-Kb Ligand From Synovial Fibroblasts
Sang-Heon Lee1, Jung-Hwa Lee1, Hae-Rim Kim1 and Kyoung-Woon Kim2, 1Konkuk University Medical Center, Seoul, South Korea, 2Konkuk University, Institute of Biomedical Science and Technology, South Korea
Leptin Promotes Th17 Responses
Yiyun Yu1, Yaoyang Liu1 and Antonio La Cava2, 1UCLA, Los Angeles, 2Univ of California Los Angeles, Los Angeles, CA
Differential Regulation of Serum Cytokine Profiles In Patients with Rheumatoid Arthritis Treated with Tocilizumab: Possible Involvement of Macrophage Migration Inhibitory Factor
Tsuyoshi Kasama1, Kuninobu Wakabayashi1, Takeo Isozaki2, Hidekazu Furuya1, Ryo Yanai1, Kumiko Ohtsuka1, Michihito Sato1 and Ryo Takahashi1, 1Showa University School of Med, Shinagawa-ku Tokyo, Japan, 2University of Michigan Medical School, Ann Arbor, MI
Glucosamine Sulphate Reduces the Prostaglandin E2 Production In Osteoarthritic Cartilage Through the Inhibition of Microsomal Prostaglandin E Synthase-1
Mohit Kapoor, Francois Mineau, Hassan Fahmi, Jean Pierre Pelletier and Johanne Martel-Pelletier, Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Notre-Dame Hospital, Montreal, QC
Role of Transcription Factor Fli-1 in Regulation of Dendritic Cell and Monocyte Development
Eiji Suzuki1, Sarah Williams2, Eva Karam1, Gary S. Gilkeson3 and Xian Zhang3, 1Medical University of South Carolina, Charleston, SC, 2Ralph H. Johnson VA Medical Center, Charleston, SC, 3Medical University of South Carolina and Ralph H. Johnson VA Medical Center, Charleston, SC
Resveratrol Deacetylating Rela/p65 Contributes to Inhibit Transforming Growth Factor-Alpha Induced Inflammation Via a Sirt1 Dependent Manner
Xiaoxia Zhu1, Meimei Wang2, Jianhua Qiu3 and Hejian Zou1, 1Division of Rheumatology, Huashan Hospital, Fudan University, Shanghai, China, 2Division of Rheumatology, Zhongda Hospital, Dongnan University, Nanjing, China, 3Neuroscience Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA
  Fasting Expands Regulatory T Cells in Lupus Mice
Yaoyang Liu1, Yiyun Yu1 and Antonio La Cava2, 1UCLA, Los Angeles, 2Univ of California Los Angeles, Los Angeles, CA
Microarray Gene Expression Profiling of Articular Chondrocyte In Patients with Osteoarthritis
Ying-Juan Chen1, Ci-Bo Huang1, Su-Ping Niu1, Ai-Hua Liu, Bei Lai and Chun-Mei Zhang, 1Beijing Hospital, Beijing, China
Progesterone Modulates Interferon-Alpha-Inducible Gene Expression in Human Leukocytes
Michael Cho1, John Zheng2 and Grant C. Hughes2, 1Univ of Wash School of Medicine, Seattle, WA, 2University of Washington, Seattle, WA
Temperature Sensitive Transient Receptor Potential Channels in Human Peripheral Blood Mononuclear Cells Enhance the LPS-Mediated Cytokine Response
Monique Stoffels, Lonneke M. Elders, Heleen D. de Koning, Jos W. M. van der Meer and Anna Simon, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands
Synergy Between Adiponectin and Interleukin-1ß on the Expression of Interleukin-6, Interleukin-8, and Cyclooxygenase-2 in Fibroblast-Like Synoviocytes
Yeon-Ah Lee1, Sang-Hoon Lee2, Hyung-In Yang2, So Mi Kim1, Seung-Jae Hong1, Myung Chul Yoo3 and Kyoung Soo Kim1, 1Kyung Hee University, Seoul, South Korea, 2Kyung Hee University Hospital at KANGDONG, Kyung Hee University, Seoul, South Korea, 3Kyung Hee University Hospital at KANGDONG, Seoul, South Korea
The Discordant Impact of IL-1 Signaling on Experimental Uveitis and Arthritis
Holly L. Rosenzweig1, Stephen R. Planck1, April L. Woods1, Jenna S. Clowers2, Martin J. Nicklin3 and James T. Rosenbaum1, 1Oregon Health & Science University, Portland, OR, 2Veterans Affairs Medical Center, Portland, OR, 3University of Sheffield, United Kingdom
The Expression of the Receptor for Advanced Glycation End-products  in Fibroblast Like synoviocytes  From Rheumatoid Arthritis Patients Is Induced by Interleukin-17
Young Ok Jung1, Mila Cho2, Hae-Rim Kim3, Sang-Heon Lee4, Sung-Hwan Park5, Hye-Jwa Oh2 and Ho-Youn Kim5, 1Seoul, South Korea, 2Catholic Medical Univ, Seoul, South Korea, 3Konkuk University Medical Center, Seoul, South Korea, 4Konkuk University Hospital, Seoul, South Korea, 5Division of Rheumatology, Department of Internal Medicine, School of Medicine, The Catholic University of Korea, Seoul, South Korea
Interleukin 17 Increased Cadherin 11 Expression in rheumatoid Arthritis
Young Eun Park1, Seong Hu Park2, Seung Geun Lee2, Seung Hoon Baek3, Geun Tae Kim4, Jun Hee Lee5, Joung Wook Lee6, Mi La Cho7 and Sung Il Kim1, 1PUSAN NATIONAL UNIVERSITY HOSPITAL, Busan, South Korea, 2Pusan Nationl University Hospital, Busan, South Korea, 3PUSAN NATIONAL UNIVERSITY YANGSAN HOSPITAL, Yangsan, South Korea, 4Kosin University Gopsel Hospital, Pusan, South Korea, 5Ilsin Christian Hospital, Pusan, South Korea, 6Busan st. Mary's Medical Center, Busan, South Korea, 72The Rheumatism Research Center, Catholic Research Institute of Medical Science, The Catholic University of Korea, Seoul, South Korea
Type-1 Interferon Does Not Directly Impair Endothelial Cell Function in Vitro:  Implications for Cardiovascular Models of Systemic Lupus Erythematosus
John A. Reynolds1, David W. Ray1, Terence O'Neill1, M. Yvonne Alexander1 and Ian N. Bruce2, 1The University of Manchester, Manchester, United Kingdom, 2A, Manchester, United Kingdom
Polymyalgia Rheumatica Has a Nocturnal Rise in Serum Interleukin-6 Which Is Almost Completely Suppressed by Nighttime Prednisone
Samy Zakout and John R. Kirwan, University Hospitals Bristol NHS Foundation Trust, Bristol, United Kingdom
Early Growth Response factor−1 Mediates the Suppressive Effect of Interleukin-1 on Peroxisome proliferator–activated Receptor Gamma Expression in Human Osteoarthritic Chondrocytes
Sarah S. Nebbaki1, Fatima Ezzahra El Mansouri2, Nadia Zayed2, Mohamed Benderdour3, Johanne M. Pelletier2, Jean Pierre Pelletier2 and Hassan Fahmi2, 1Osteoarthritis Research Unit, University of Montreal Hospital Research Center (CRCHUM), Notre-Dame Hospital, Montreal, QC, 2Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Notre-Dame Hospital, Montreal, QC, 3University of Montreal Hospital Research Centre , Sacré-Coeur Hospital, Montreal, QC
Circulating cytokines in Patients with Hidradenitis Suppurativa: is there a Clue for new Therapeutic Options?
Orlando Pompei1, Lorena Álvarez-Rodríguez1, Ricardo Blanco1, Ignacio Villa2, Marcos López-Hoyos1, Marcos González López1, Hector Fernandez-Llaca1, M. del Carmen Gonzalez Vela1, Carmen Bejerano1, Inés Pérez-Martín1 and Victor M. Martinez-Taboada1, 1Hospital Universitario Marqués de Valdecilla-IFIMAV, Santander, Spain, 2Hospital Sierrallana, Torrelavega, Spain
Differential Production of Angiopoietins-1 and -2 in Synovial Tissue of Rheumatoid Arthritis and Psoriatic Arthritis Patients Is Associated with Expression of Specific Putative Transcription Factors
M. Frleta, L.G.M. van Baarsen, A.M. Grabiec, D. de Launay, M. Garrelfs, D. Gerlag, PP. Tak and K.A. Reedquist, Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
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