Cytokines, Mediators, and Gene Regulation

Session Type: ACR Abstract Submissions
Tuesday, November 8, 2011: 9:00 AM-6:00 PM
Hall F2 - Poster Hall (McCormick Place West)
Papers:
Induction of Tyrosine Hydroxylase (TH) and Modulation of Cytokine Release by Hypoxia in Mixed Synovial Cells of Patients with Rheumatoid Arthritis and Osteoarthritis
Silvia Capellino1, Zsuzsa Jenei-Lanzl1 and Rainer H. Straub2, 11Laboratory of Experimental Rheumatology and Neuroendocrine Immunology, Department of Internal Medicine, University Hospital Regensburg, Regensburg, Germany, 2University Hospital Regensburg, Regensburg, Germany
Synovial Tissue Cytokine Expression in Rheumatoid Arthritis and Associations with Lymphoid Neogenesis, Disease Activity and the European League Against Rheumatism Response
Juan D. Canete1, Raquel Celis2, Julio Ramirez1, Sara Marsal3, Gabriel Avila3, Raimon Sanmarti2 and Jose L. Pablos4, 1Hospital Clinic, Barcelona, Spain, 2Clinic Hospital, Barcelona, Spain, 3Hospital Vall de Hebró, Grup de Recerca de Reumatologia, Barcelona, Spain, 4Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain
Mucocutaneous Flares As Opposed to Flares From Other Organs Have the Strongest Association with High Type I Interferon Levels in Patents with Systemic Lupus Erythematosus
Elzbieta E. Jacek1, Mikhail Olferiev2, Vinicius Domingues3, Rolando Duculan1, Nancy Pan4, Mary K. Crow4 and Kyriakos A. Kirou5, 1Mary Kirkland Center for Lupus Research-Hospital for Special Surgery, New York, NY, 2Mary Kirkland Center for Lupus Research, Hospital for Special Surgery, New York, NY, 3Estacio de Sá University, Rio de Janeiro, Brazil, 4Hospital for Special Surgery, New York, NY, 5Mary Kirkland Center for Lupus Care, Hospital for Special Surgery, New York, NY
Atherogenic Properties of Rheumatoid Arthritis and SLE Plasma Are Attenuated by Interferon-γ Depletion
Allison B. Reiss, Iryna Voloshyna, Michael J. Littlefield, Elise Belilos, Kristina B. Belostocki, Lois A. Bonetti, Gary C. Rosenblum and Steven E. Carsons, Winthrop University Hospital, Mineola, NY
Potentiation of TNF-Induced T Cell Chemokine Expression by Type I Interferon in Fibroblast-Like Synoviocytes: Target for JAK Inhibition
Sanna Rosengren, Gary S. Firestein and David L. Boyle, UCSD School of Medicine, La Jolla, CA
IL-6 and TNF-α Enhance the Expression of U1C and Affect the Splicing of Functional Defective Angiopoietin-1 (Ang1) Gene Mediated by Anti-U1C Antibody in the Patients with MCTD
Tatsuki Okuyama1, Yuka Kosugi1, Koichiro Komai1, Akira Hashiramoto2, Kazuko Shiozawa3 and Shunichi Shiozawa2, 1Graduate School of Health Sciences, Kobe Univ., Kobe, Japan, 2Graduate School of Health Sciences and Medicine, Kobe Univ. / The Center for Rheumatic Diseases, Kobe Univ., Hosp., Kobe, Japan, 3Rheumatic Diseases Center, Konan Kakogawa Hospital, Kakogawa, Japan
Chemerin/ChemR23 Expression and Pro-Inflammatory Effects in  Synovitis of Patients with Rheumatoid Arthritis
Hirahito Endo, Makoto Kabraki, Yoshie Kusunoki, Natsuko Kusunoki and Shinichi Kawai, Toho University School of Medicine, Tokyo, Japan
Functional Characterization of An Allosteric Enhancer of the Adenosine A2a Receptor That Inhibits Pro-Inflammatory Cytokine Production
Ajith A. Welihinda and Edward P. Amento, Molecular Medicine Research Institute, Sunnyvale, CA
Mechanism of Fractalkine/CX3CL1 Synthesis and Shedding in Rheumatoid Arthritis Synovial Fibroblasts
Brian Jones, Maria Beamer, Ayesha Rahman, Wissam Ali Aboualaiwi and Salahuddin Ahmed, Department of Pharmacology, University of Toledo College of Pharmacy & Pharmaceutical Sciences, Toledo, OH
Comparison of Anti-Interleukin-6 and Anti-Interleukin-6 Receptor Antibodies Using In Vivo Functional Systems
Stevan Shaw, Diane Marshall, Helen Neale, Kosmas Kretsos, Tim Bourne and Alastair Lawson, UCB, Slough, United Kingdom
Oncostatin M Is a Potent Regulator of Interleukin-6 and RANKL Expression in Mouse Synovial Fibroblasts and Synergises with Interleukin-1
Benoit Le Goff, Brett A. Tonkin, Sofie Singbrant, T. John Martin, Evange Romas, Natalie A. Sims and Nicole C. Walsh, St Vincent's Institute of Medical Research, Melbourne, Australia
Late Apoptotic Bodies Mediates Sterile Inflammation in Vitro and In Vivo Via IL-1alpha
Yael Berda-Haddad1, Stéphane Robert1, Paul Salers1, Leila Zekraoui2, Catherine Farnarier3, Charles A. Dinarello4, Françoise Dignat-George1 and Gilles Kaplanski1, 1INSERM U608, Marseille, France, 2Faculté de Médecine-Timone, Marseille, France, 3Hopital de la Conception, Marseille, France, 4Denver, CO
Fatty Acid-Binding Protein (FABP)-4 Is Increased in Patients with Rheumatoid Arthritis and Correlates with Metabolic Rather Than with Disease Activity Status
Lucie Andrés Cerezo1, Hana Hulejová1, Zdenka Vernerová2, Markéta Kuklová1, Ondrej Pecha3, Vlasta Pesáková1, Karel Pavelka1, Jiri Vencovsky1 and Ladislav Senolt1, 1Institute of Rheumatology, Department of Experimental Rheumatology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, 2Department of Pathology, 3rd Medical Faculty, Charles Universityin Prague, Prague, Czech Republic, 3Institute of Biophysics and Informatics, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
Role of Liver X Receptors In the Regulation of Effector Functions of Fibroblast-Like Synoviocytes In Rheumatoid Arthritis
M.Teresa Arce-Franco1, M. Jesus Dominguez-Luis2, Ana Diaz-Martin2, Ada Herrera-Garcia3, Maria Eugenia Miranda-Carus4, Sagrario Bustabad-Reyes3, Antonio Castrillo5 and Federico Diaz-Gonzalez1, 1Rheumatology Service, La Laguna, Spain, 2Hospital Universitario de Canarias, La Laguna, Spain, 3Hospital Universitario de Canarias, La Laguna. Tenerife, Spain, 4La Paz Hospital. IdiPaz, Madrid, Spain, 5University of Las Palmas de Gran Canaria (ULPGC), Canary Islands, Las Palmas (Gran Canaria), Spain
Poly I:C, a Ligand for TLR3, Abrogates Stimulation of Fibrotic Response Induced by Transforming Growth Factor-β
Feng Fang1, Kohtaro Ooka2, Swati Bhattacharyya3 and John Varga3, 1Northwestern University, Chicago, IL, 2Northwestern University, 3Northwestern Univ Med School, Chicago, IL
Visfatin and B-Cell Activating Factor of the TNF Family Serum Levels Correlate with Disease Activity in Anti-Jo-1 Positive Patients with Idiopathic Inflammatory Myopathies
Hana Hulejová1, Olga Kryštufková1, Klára Kuncová2, Josef Zámecník2, Herman F. Mann1, Ladislav Senolt1 and Jiri Vencovsky1, 1Institute of Rheumatology,1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic, 22nd Medical School and University Hospital Motol, Charles University, Prague, Czech Republic, Prague, Czech Republic
FMS-Like Tyrosine Kinase 3 Ligand/CD135 in Arthritis: A New Inflammatory System in RA?
Maria I. Martins Ramos, Saïda Aarrass, Lisa G.M. van Baarsen, Danielle M. Gerlag, PP. Tak and Maria C. Lebre, Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
Adiponectin Isoforms Differentially Affect Gene Expression, Signaling Transduction and Migration of Rheumatoid Arthritis Synovial Fibroblasts
Klaus Frommer1, Rosel Engel1, Andreas Schäffler2, Christa Büchler2, Jürgen Steinmeyer3, Markus Rickert3, Stefan Rehart4, Fabia Brentano5, Steffen Gay6, Ulf Müller-Ladner1 and Elena Neumann1, 1Justus-Liebig-University of Gießen, Bad Nauheim, Germany, 2University of Regensburg, Regensburg, Germany, 3University Hospital Gießen and Marburg, Gießen, Germany, 4Markus-Hospital, Frankfurt, Germany, 5University Hospital Zürich, 6University Hospital of Zürich, Zürich, Switzerland
F-Spondin Mediates Catabolic Effects on Articular Chondrocytes Via Its Thrombospondin Repeat Domain
James Liu1, Glyn Palmer1, Yang Qing2, Daniel Rifkin2, Mukundan Attur1 and Steven B. Abramson1, 1NYU Hospital for Joint Diseases, New York, NY, 2New York University School of Medicine, New York, NY
Adipokine Expression in Osteoarthritis Osteophytes
Susann Junker1, Klaus Frommer1, Grit Krumbholz1, Angela Lehr2, Stefan Rehart2, Markus Rickert3, Jürgen Steinmeyer3, Georg Schett4, Ulf Müller-Ladner1 and Elena Neumann1, 1Justus-Liebig-University of Gießen, Bad Nauheim, Germany, 2Markus-Hospital, Frankfurt, Germany, 3University Hospital Gießen and Marburg, Gießen, Germany, 4University of Erlangen-Nuremberg, Erlangen, Germany
Increasing Serum IL-17F Levels in Pediatric Localized Scleroderma As Disease Enters Remission
Kathryn S. Torok1, Katherine Kurzinski1, Christina Kelsey1 and Carol A. Feghali-Bostwick2, 1Univ of Pittsburgh Med Ctr, Pittsburgh, PA, 2University of Pittsburgh, Pittsburgh, PA
TWEAKing Cutaneous Manifestations In MRL-Lpr/Lpr Lupus Prone mice  
Yumin Xia1, Karin Blecher1, Jing Wen1, Jennifer S. Michaelson2, Linda C. Burkly2, Adam Friedman1 and Chaim Putterman3, 1Albert Einstein College of Med, Bronx, NY, 2Biogen Idec, Cambridge, MA, 3Albert Einstein College of Medicine, Bronx, NY
Pro-Inflammatory Cytokine Measurement in Whole Blood Cultures Stimulated with Lipopolysaccharide Predicts Treatment Outcomes of Patients with Rheumatoid Arthritis Treated with Biologics
Ken Kayakabe1, Takashi Kuroiwa2, Noriyuki Sakurai1, Hidekazu Ikeuchi1, Anastasie K.T.1, Toru Sakairi1, Akito Maeshima1, Keiju Hiromura1 and Yoshihisa Nojima1, 1Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan, 2Jichi Medical University, Saitama Medical Center, Saitama, Japan
Mitochondrial Mutagenesis Correlates with the Local Inflammatory Environment in Arthritis
Leonard C. Harty1, Monika Biniecka1, Edward Fox2, Jacintha N. O'Sullivan3, Ursula Fearon1 and Douglas J. Veale1, 1Translation Rheumatology Research Group, Dublin, Ireland, 2University of Washington, Seattle, WA, 3Trinity University, Dublin, Ireland
The Role of IL-17 in Systemic Lupus Erythematosus
Gil Amarilyo, University of California, Los Angeles, Los Angeles, CA, Elaine Lourenco, UCLA David Geffen School of Medicine, Los Angeles, CA and Antonio La Cava, Univ of California Los Angeles, Los Angeles, CA
A Specific Microrna Pattern Discriminates Synovial Macrophages From Rheumatoid Arthritis and Osteoarthritis Patients
Andrea Diaz-Alderete1, Vanessa Miranda2, Ignacio Caballero1, Manuel Tardaguila1, Alberto Pascual-Montano1, Jose L. Pablos2 and Santos Mañes1, 1Centro Nacional de Biotecnología- CSIC, Madrid, Spain, 2Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain
The Influence of Interleukin-32γ on Osteoclastogenesis, with a Focus on Fusion-Related Genes
Bon San Koo, Yong-Gil Kim, Min Wook So, Chang-Keun Lee and Bin Yoo, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea
Identification of Activated Cytokine Pathways in the Blood of Systemic Lupus Erythematosus, Myositis, Rheumatoid Arthritis, and Scleroderma Patients
Brandon W. Higgs1, Wei Zhu1, Laura Richman1, David Fiorentino2, Steven A. Greenberg3, Bahija Jallal1 and Yihong Yao1, 1MedImmune, Gaithersburg, MD, 2Stanford, Stanford, CA, 3Brigham Women's Hospital, Harvard Medical School, Boston, MA
Systemic Lupus Erythematosus, Myositis, Rheumatoid Arthritis, and Scleroderma Patients Share Activation of a Common Type I Interferon Pathway
Brandon W. Higgs1, Zheng Liu1, Barbara White1, Wei Zhu1, Wendy White1, Chris Morehouse1, Philip Brohawn1, Peter Kiener1, Laura Richman1, David Fiorentino2, Steven A. Greenberg3, Bahija Jallal1 and Yihong Yao1, 1MedImmune, Gaithersburg, MD, 2Stanford, Stanford, CA, 3Brigham Women's Hospital, Harvard Medical School, Boston, MA
Extracellular 14-3-3η: A Novel Mediator of Inflammation Associated with Selective Activation of Intracellular Pathways
Anthony Marotta1, Yuan Gui1, Aziz Ghahary2, Ruhangiz Kilani2 and Walter P. Maksymowych3, 1Augurex Life Sciences Corp, North Vancouver, BC, 2University of British Columbia, Vancover, BC, 3University of Alberta, Edmonton, AB
Serum Galectin-3 Level in Patients with Scleroderma
Metin Ozgen1, Suleyman Serdar Koca1, Fatma Akbas1, Nevin Ilhan2, Baris Gundogdu1 and Ahmet Isik1, 1Department of Rheumatology, Faculty of Medicine, Firat University, Elazig, Turkey, 2Department of Biochemistry, Faculty of Medicine, Firat University, Elazig, Turkey
Atherogenic Effect of Inflammatory Cytokines in Chronic Inflammatory Diseases
Misato Hashizume and Masahiko Mihara, Chugai Pharmaceutical Co., Ltd., Gotemba, Shizuoka, Japan
Follistatin-Like Protein 1 Promotes Arthritis by Enhancing Cytokine/Chemokine Gene Expression
Yury Chaly1, Anthony Marinov1, Leif Oxburgh2, Daniel Bushnell1 and Raphael Hirsch1, 1Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, 2Maine Medical Center Research Institute, Scarborough, ME
Decreased Interleukin-22 in Pulmonary Fibrosis: Potential Role As a Regulatory Cytokine
Minrui Liang1, Xiangjun Chen2, Jiu-Cun Wang3, Min Guan2, Haiyan Chu4 and Hejian Zou5, 1Huashan Hospital,Fudan University,Shanghai, Shanghai, China, 2Huashan Hospital, Fudan University, Shanghai, China, 3Fudan University, Shanghai, China, 4School of Life Science, Fudan University, China, 5Huashan Hospital, Shanghai, China
Bridging ELISA As a Screening Assay to Monitor Immunogenicity in Routine Clinical Practice
Sandra Garcês, Instituto Gulbenkian Ciência; Hospital Garcia de Orta, Oeiras, Portugal, Jocelyne Demengeot, Instituto Gulbenkian Ciência, Oeiras, Portugal, J. Canas da Silva, Hospital Garcia de Orta, Almada, Portugal and L. Aarden, Sanquin Research and Landsteiner Laboratory, Amsterdam, Netherlands
In Vivo Gene Transfer of IL-17A Induces Osteoclast Formation in a RANKL-Dependent Manner, Exacerbates Collagen-Induced Arthritis and Induces Epidermal Hyperplasia
Iannis E. Adamopoulos, UC Davis, Sacramento, CA, Cheng-Chi Chao, Merck, Palo Alto, CA and Eddie P. Bowman, Merck, Palo Alto
FMS-Like Tyrosine Kinase 3 Receptor Inhibition Leads to Decreased Production of Interleukin 6 by Synovial Biopsies, Fibroblast-Like Synoviocytes and Monocytic Cells From Arthritic Patients
Maria I. Martins Ramos, Saïda Aarrass, Danielle M. Gerlag, PP. Tak and Maria C. Lebre, Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
Anti-Inflammatory Activity of Apremilast Against T Cells, Chondrocytes, and Rheumatoid Arthritis Synovial Fibroblasts in Vitro
Lori Capone, Audry Rogovitz, Anita Gandhi and Peter Schafer, Celgene Corporation, Summit, NJ
C5orf30 a Candidate Susceptibility Gene in Rheumatoid Arthritis
Sachin Khetan1, Munitta Muthana1 and A. G. Wilson2, 1Dr, Sheffield, United Kingdom, 2Sheffield Uni /Medical School, Sheffield, United Kingdom
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