Systemic Lupus Erythematosus - Human Etiology and Pathogenesis II: Genetics

Session Type: ACR Abstract Submissions
Tuesday, November 8, 2011: 2:30 PM-4:00 PM
W474a (McCormick Place West)
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Moderators: Kathy L. Moser, PhD, Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation and Betty P. Tsao, PhD, UCLA School of Medicine
Papers:
2:30 PM
A Large-Scale, Multi-Racial Replication Study Identifies Novel Systemic Lupus Erythematosus Susceptibility Loci At IRF8, TMEM39A, and IKZF3/ZPBP2
Christopher J. Lessard1, Indra Adrianto1, John A. Ice1, Jennifer A. Kelly1, He Li1, Graham B. Wiley1, Astrid Rasmussen1, Marta E. Alarcon-Riquelme2, Juan-Manuel Anaya3, Sang-Cheol Bae4, Elizabeth E. Brown for PROFILE5, Chaim O. Jacob6, Judith A. James7, Javier Martin8, Timothy B. Niewold9, Bernardo Pons-Estel10, Betty P. Tsao11, Timothy J. Vyse12, John B. Harley13, Edward Wakeland14, Kenneth M. Kaufman15, Courtney Montgomery1, Carl D. Langefeld16, Patrick M. Gaffney17 and Kathy L. Moser17, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Oklahoma Medical Research Foundation, Center for Genomics and Oncological Research Pfizer-University of Granada-Junta de Andalucia, Oklahoma City, OK, 3Universidad del Rosario-Corporacion para Investigaciones Biologicas, Bogota, Colombia, 4Hanyang University Hospital for Rheumatic Diseases, Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, South Korea, 5University of Alabama at Birmingham, Birmingham, AL, 6Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, 7Oklahoma Medical Research Foundation and Oklahoma University Health Sciences Center, Oklahoma City, OK, 8Instituto de Parasitologia y Biomedicina Lopez-Neyra (CSIC), Granada, Spain, 9University of Chicago, Chicago, IL, 10Rosario, Argentina, 11UCLA School of Medicine, Los Angeles, CA, 12Divisions of Genetics and Molecular Medicine and Immunology, King's College London, London, United Kingdom, 13Cincinnati Children's Hospital Medical Center and the US Department of Veterans Affairs Medical Center, Cincinnati, OH, 14Univ of Texas SW Med Ctr, Dallas, TX, 15Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation and US Department of Veterans Affairs Medical Center, Oklahoma City, OK, 16Wake Forest University Health Sciences, Winston-Salem, NC, 17Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK
2:45 PM
Identification of Novel Genetic Susceptibility Loci In African-American lupus patients Using a Candidate Gene Association Study
Elena Sanchez1, Mary E. Comeau2, Barry I. Freedman2, Jennifer A. Kelly1, Kenneth Kaufman3, Carl D. Langefeld2, Elizabeth E. Brown for PROFILE4, Robert P. Kimberly4, Jeffrey C. Edberg5, Rosalind Ramsey-Goldman6, M. Petri7, John D. Reveille8, Luis M. Vila9, J.T. Merrill1, Betty P. Tsao10, Diane L. Kamen11, Gary S. Gilkeson12, Judith A. James13, Tomothy J. Vyse14, Patrick M. Gaffney15, Chaim O. Jacob16, Timothy B. Niewold17, Bruce C. Richardson18, John B. Harley19, Marta E. Alarcon-Riquelme20 and Amr H. Sawalha1, 1Oklahoma Medical Research Foundation, Oklahoma City, OK, 2Wake Forest University Health Sciences, Winston-Salem, NC, 3Oklahoma Medical Research Foundation, Oklahoma CIty, OK, 4University of Alabama at Birmingham, Birmingham, AL, 5Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 6Northwestern University, Chicago, IL, 7Johns Hopkins University School of Medicine, Baltimore, MD, 8University of Texas Health Science Center at Houston, Houston, TX, 9University of PuertoRico Medical Sciences Campus, San Juan, PR, 10UCLA School of Medicine, Los Angeles, CA, 11Medical University of SC, Charleston, SC, 12Division of Rheumatologyand Immunology, Medical University of South Carolina, Charleston, SC, 13Oklahoma Medical Research Foundation and Oklahoma University Health Sciences Center, Oklahoma City, OK, 14King's College London, Guy's Hospital, London, United Kingdom, 15Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 16Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, 17University of Chicago, Chicago, IL, 18University of Michigan, Ann Arbor, MI, 19Cincinnati Children's Hospital Medical Center and the US Department of Veterans Affairs Medical Center, Cincinnati, OH, 20Oklahoma Medical Research Foundation, Center for Genomics and Oncological Research Pfizer-University of Granada-Junta de Andalucia, Oklahoma City, OK
3:00 PM
Risk Alleles of SLE Associated IL10 SNPs Conferred Differential Binding to Transcription Factors
Daisuke Sakurai1, Jian Zhao1, Yun Deng1, Kenneth Kaufman2, Jennifer A. Kelly3, Robert P. Kimberly on behalf of PROFILE investigators4, Marta E. Alarcón-Riquelme on behalf of the BIOLUPUS and GENLES networ5, John B. Harley6, Sang-Cheol Bae7, Chaim O. Jacob8, Timothy J. Vyse9, Timothy B. Niewold10, Patrick M. Gaffney11, Kathy L. Moser11, Judith A. James12, Gary S. Gilkeson13, Diane L. Kamen14, Carl D. Langefeld15, Deh-Ming Chang16, Yeong Wook Song17, Chack-Yung Yu18, Jennifer M. Grossman19, Rita M. Cantor20, Bevra H. Hahn19 and Betty P. Tsao1, 1David Geffen School of Medicine University of California Los Angeles, Los Angeles, CA, 2Oklahoma Medical Research Foundation, Oklahoma CIty, OK, 3Oklahoma Medical Research Foundation, Oklahoma City, OK, 4Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, 5Oklahoma Medical Research Foundation; Center for Genomics and Oncological Research, Oklahoma City; Granada, Spain, OK, 6Cincinnati Children's Hospital Medical Center and the US Department of Veterans Affairs Medical Center, Cincinnati, OH, 7Hanyang University Hospital for Rheumatic Diseases, Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, South Korea, 8Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, 9Divisions of Genetics and Molecular Medicine and Immunology, King's College London, London, United Kingdom, 10University of Chicago, Chicago, IL, 11Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, 12Oklahoma Medical Research Foundation and Oklahoma University Health Sciences Center, Oklahoma City, OK, 13Division of Rheumatologyand Immunology, Medical University of South Carolina, Charleston, SC, 14Medical University of SC, Charleston, SC, 15Wake Forest University Health Sciences, Winston-Salem, NC, 16National Defense Medical Center, Taipei, 17Seoul National University College of Medicine, Seoul, South Korea, 187Center for Molecular and Human Genetics, The Research Institute at Nationwide Children's Hospital and The Ohio State University, Columbus, OH, 19UCLA David Geffen School of Medicine, Los Angeles, CA, 20University of California Los Angeles, Los Angeles, CA
3:15 PM
Determination of the Contribution of An IRF5-SLE Risk Haplotype to IRF5 expression and Alternative Splicing Using Next-Generation Sequencing
Rivka Stone1, Peicheng Du2, Di Feng1, Lars Ronnblom3, Maija-Leena Eloranta4, Robert Donnelly1 and Betsy Barnes1, 1University of Medicine and Dentistry of New Jersey, Newark, NJ, 2New Jersey Medical School, Newark, NJ, 3Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala, Sweden, 4Section of Rheumatology, Uppsala University, Uppsala, Sweden
3:30 PM
Lupus Nephritis Susceptibility Markers in PDGRFA-GSX2, SLC5A11, ID4, and HAS2-SNTB1 Regions Identified From a Meta-Analysis of Genome Wide Association Studies of Women with Systemic Lupus Erythematosus
Sharon A. Chung1, Elizabeth E. Brown2, Adrienne H. Williams3, Tushar Bhangale4, Paula S. Ramos3, Julie T. Ziegler3, Barry I. Freedman3, Robert P. Kimberly2, Timothy J. Vyse5, Peter K. Gregersen6, Chaim O. Jacob7, Marta E. Alarcon-Riquelme8, Betty P. Tsao9, John B. Harley10, Timothy W. Behrens4, M. Petri11, M. Ilyas Kamboh12, F. Yesim Demirci12, Susan Manzi13, Lindsey A. Criswell1, Kathy L. Moser14, Patrick M. Gaffney14, Robert R. Graham4 and Carl D. Langefeld3, 1University of California, San Francisco, San Francisco, CA, 2University of Alabama at Birmingham, Birmingham, AL, 3Wake Forest School of Medicine, Winston-Salem, NC, 4Genentech, Inc., South San Francisco, CA, 5King's College London, London, United Kingdom, 6Feinstein Institute for Medical Research, Manhasset, NY, 7University of Southern California, Los Angeles, CA, 8Oklahoma Medical Research Foundation, Center for Genomics and Oncological Research Pfizer-University of Granada-Junta de Andalucia, Oklahoma City, OK, 9University of California, Los Angeles, Los Angeles, CA, 10Cincinnati Children's Hospital Medical Center and the US Department of Veterans Affairs Medical Center, Cincinnati, OH, 11Johns Hopkins University School of Medicine, Baltimore, MD, 12University of Pittsburgh, Pittsburgh, PA, 13Allegheny Singer Research Institute, Pittsburgh, PA, 14Oklahoma Medical Research Foundation, Oklahoma City, OK
3:45 PM
Association of STAT4, IRF5 and BLK Polymorphisms with Severity and Outcome in Lupus Nephritis
Karin G. Eriksson1, Agneta Zickert2, Johanna K. Sandling3, Andreas Jönsen4, Elisabet Svenungsson2, Lars Rönnblom1, Timothy W. Behrens5, Robert R. Graham5, Ward Ortmann5, Ann-Christine Syvänen3, Iva Gunnarsson2 and Gunnel Nordmark6, 1Section of Rheumatology, Uppsala University, Uppsala, Sweden, 2Rheumatology Unit, Karolinska Institutet, Stockholm, Sweden, 3Molecular Medicine, Uppsala University, Uppsala, Sweden, 4Section of Rheumatology, Lund University, Lund, Sweden, 5Genentech Inc, South San Francisco, CA, 6Department of Medical Sciences, Section of Rheumatology, Uppsala University, Uppsala, Sweden
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