Spondylarthropathies and Psoriatic Arthritis - Pathogenesis, Etiology

Session Type: ACR Abstract Submissions
Monday, November 7, 2011: 9:00 AM-6:00 PM
Hall F2 - Poster Hall (McCormick Place West)
Papers:
Association of Platelet Endothelial Cell Adhesion Molecule-1 and β1 Integrin Gene Polymorphisms with Uveitis Development in Ankylosing Spondylitis
Seung Cheol Shim, Donghyuk Sheen, Mi-Kyoung Lim, Jiyoung Kim, Soyoung Lee and Sangkwang Lee, Eulji University Hospital, Daejeon, South Korea
Predictive and Protective Value of Biomarkers in Patients with Ankylosing Spondylitis Who Are At High Risk of Radiographic Spinal Progression
Denis Poddubnyy1, Kristina Conrad2, Gisela Ruiz-Heiland3, Uta Syrbe2, Hildrun Haibel2, Heiner Appel2, Martin Rudwaleit4, Georg Schett3 and Joachim Sieper2, 1Charité Medical University, Campus Benjamin Franklin, Berlin, Germany, 2Charité – Campus Benjamin Franklin, Berlin, Germany, 3University of Erlangen-Nuremberg, Erlangen, Germany, 4Ev. Krankenhaus Hagen-Haspe, Hagen, Germany
Increased T Cell Receptor Clonotype Sharing Among Ankylosing Spondylitis Patients Revealed by Deep Repertoire Sequence Analysis 
Malek Faham1, Victoria Carlton1, Martin Moorhead1, Jianbiao Zheng1, Tom Asbury1 and R. D. Inman2, 1Sequenta, Inc., San Francisco, CA, 2The Arthritis Program, Toronto Western Hospital and Division of Rheumatology, Toronto Western Hospital and University of Toronto, Toronto, ON
Family-Based Association Study of SPA3, a New Susceptibility Locus for Spondyloarthritis on 6p11-q11
Félicie Costantino1, Brigitte Izac1, Gilles Chiocchia2, Roula Said-Nahal3, Ariane Leboime3, Elena Zinovieva1, Diana Zelenika4, Maxime A. Breban3 and Henri-Jean Garchon1, 1Institut Cochin, Paris, France, 2Institut Cochin, 75014 Paris, France, 3Ambroise Paré Hospital, Boulogne-Billancourt, France, 4Centre National de Génotypage, Evry
Highly Expressed HLA-B27 Accumulate in Subcellular Vesicular Compartments and Form Oligomers That Behave Differently From HLA-B7
Cindy Jeanty1, Adèle Sourisce1, Aurore Wielgosik1, Maxime A. Breban2 and Claudine André1, 1Institut Cochin, 75014 Paris, France, 2Hopital Ambroise Pare, Boulogne, France
Exacerbated Uveitis in the Context of IFN-Gamma Deficiency Is Ameliorated by Blockade of the Th17 Response in a murine model of Proteoglycan-Induced Arthritis and Spondylitis
Holly L. Rosenzweig1, Jelena M. Kezic1, Michael P. Davey2, Stephen R. Planck1, Tibor T. Glant3 and James T. Rosenbaum1, 1Oregon Health & Science University, Portland, OR, 2Veterans Affairs Medical Center, Portland, OR, 3Rush University Medical Center, Chicago, IL
Identification of Immunogenic HLA-B*27:05 Restricted Peptides of Salmonella Outer Membrane Protein (OMP) in Patients with Reactive Arthritis and Undifferentiated Spondyloarthropathy
Ramnath Misra1, Amit Singh1 and Amita Aggarwal2, 1Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, 2Additional Professor Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Lucknow, India
Endoplasmic Reticulum Aminopeptidase 1 Interaction with Human Leukocyte Antigen B27 Influences the Unfolded Protein Response
Nigil Haroon1, Aifeng Lin2, Ali Akram1 and Robert D. Inman1, 1Toronto Western Research Institute, University Health Network and University of Toronto, Toronto, ON, 2Toronto Western Research Institute and University Health Network, Toronto, ON
Phenotype of Resting and Activated Monocyte-Derived Dendritic Cells Grown From Peripheral Blood of Patients with Ankylosing Spondylitis
Gleb Slobodin1, Aharon Kessel1, Natalia Kofman2, Elias Toubi1, Itzhak A. Rosner1 and Majed Odeh1, 1Bnai Zion Medical Center, Haifa, Israel, 2Technion, Haifa, Israel
Chondrocalcin, C-Terminal Propeptide of Type II Collagen, Can Be Found in Sclerotic Lesions of Spine and Its Gene Expression Is Significantly Increased in Patients with Ankylosing Spondylitis
Yong-Jin Kwon, Tae-Yeon Kim, Sang-Won Lee, Yong-Beom Park, Soo Kon Lee and Min-Chan Park, Yonse University College of Medicine, Seoul, South Korea
Serial Ultrasonography Documents New Bone Formation At Entheses in Spondyloarthritis
Ralf G. Thiele1, Bethany A. Marston1, Darren Tabechian2, Allen P. Anandarajah3 and Christopher T. Ritchlin4, 1University of Rochester, Rochester, NY, 2Univ of Rochester Schl of Med, Rochester, NY, 3Univ of Rochester Medical Ctr, Rochester, NY, 4University of Rochester Medical Center, Rochester, NY
Syndesmophyte Formation Is Associated with Low-Grade Spine Inflammation and Disconnected From Peripheral Arthritis in Mice Immunized with Recombinant Human Aggrecan G1 Domain
Mohamed Ramez, Toni S. Forde, Elena Kudryavtseva and Vyacheslav A. Adarichev, Albert Einstein College of Medicine, Bronx, NY
Transition From a Cartilage Phenotype Into Bone in the Intervertebral Disc End Plate in Ageing Mice: Role for Bone Morphogenetic Protein 2
Esmeralda N. Blaney Davidson1, Elly Vitters2, Wim B. van den Berg1 and Peter M. van der Kraan1, 1Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands, 2Radboud University Medical Centre Nijmegen, Nijmegen, Netherlands
Simultaneous but Spatially Distinct Occurrence of Inflammation, Tissue Destruction and Osteoproliferation in the HLA-B27/Human beta2 Microglobulin Transgenic Rat Model of Spondyloarthritis
Leonie M. van Duivenvoorde1, Martha L. Dorris2, Nimman Satumtira2, Paul P. Tak1, Joel D. Taurog2 and Dominique L. Baeten1, 1Academic Medical Center / University of Amsterdam, Amsterdam, Netherlands, 2UT Southwestern Medical Center, Dallas, TX
Inhibition of IL-17 by Antibody Administration Improves Onset of Tarsal Ankylosis In a Murine Model
Shin Ebihara and Masao Ono, Department of Pathology, Tohoku University Graduate School of Medicine, Sendai, Japan
HLA Associations Reveal Genetic Heterogeneity in Psoriatic Arthritis and in the Psoriasis Phenotype
Robert Winchester1, Gregory Minevich1, Valeria Steshenko1, Brian Kirby2, David Kane3, David A. Greenberg4 and Oliver M. FitzGerald2, 1Columbia University, New York, NY, 2St. Vincent's University Hospital, Dublin, Ireland, 3Adelaide, Meath hospital Dublin (incorporating the National Children's hospital), Dublin 24, Ireland, 4Mailman School of Public Health Columbia University, New York City, NY
Differential Human Leukocyte Allele Association Between Psoriasis and Psoriatic Arthritis – A Family-Based Association Study
Lihi Eder1, Fawnda Pellett2, Vinod Chandran2, Sutharshini Shanmugarajah2, Shelley Bull3 and Dafna D. Gladman1, 1Toronto Western Hospital, University of Toronto, Toronto, ON, 2Toronto Western Hospital and University of Toronto, Toronto, ON, 3Mount Sinai Hospital, Toronto, ON
Enhanced Expression of KIR3DL2 in Natural Killer and CD3/CD4 Positive T Cells of Ankylosing Spondylitis Patients Compared to HLA-B*2705 or B*2709 Healthy Subjects
Alberto Cauli1, Grazia Dessole1, Giovanni Porru1, Alessandra Vacca1, Matteo Piga1, Valentina Ibba1, Pietro Garau1, Simon Kollnberger2 and Alessandro Mathieu1, 1University of Cagliari, Cagliari, Italy, 2Weatherall Institute of Molecular Medicine, Oxford, United Kingdom
GDF15, a Distinct TGFb Family Member, Is Differentially Regulated in Spondyloarthritides Compared to Other Rheumatic Diseases
Stijn Lambrecht1, Julie Coudenys1, Filip De Keyser2, Gust Verbruggen3, Dieter Deforce4 and Dirk Elewaut5, 1Ghent University, Ghent, Belgium, 2Universitair Ziekenhuis Gent, Gent, Belgium, 3Universitair Ziekenhuis, B-9000 Gent, Belgium, 4Laboratory for Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium, 5Gent University Hospital, Ghent, Belgium
Extended Haplotypes Between Human Leukocyte Antigen - C and Tumour Necrosis Factor A Gene Loci Reveal Psoriatic Arthritis Susceptibility Hotspots
Remy Pollock1, Fawnda Pellett2, Renise Ayearst2, Al Amin P. Rahman3, Dafna D. Gladman1 and Vinod Chandran2, 1Toronto Western Hospital, University of Toronto, Toronto, ON, 2Toronto Western Hospital and University of Toronto, Toronto, ON, 3Memorial University, St Johns, NE
Synovial Cytokine Expression in Psoriatic Arthritis and Associations with Lymphoid Neogenesis and Clinical Features
Raquel Celis1, Raimon Sanmarti1, Julio Ramirez2, Antonio Palacin2, Jose L. Pablos3 and Juan D. Cañete4, 1Clinic Hospital, Barcelona, Spain, 2Hospital Clinic, Barcelona, Spain, 3Instituto de Investigación Hospital 12 de Octubre (I+12), Madrid, Spain, 4Hospital Clínic de Barcelona, IDIBAPS, Barcelona, Spain
Immunopathogenic Role of IL-22 and Its Receptor In Psoriatic Arthritis: Synergistic Effect of IL-22 and TNF-á In FLS Proliferation
Siba P. Raychaudhuri1, Anupam Mitra2, Ananya Datta Mitra3 and Smriti K. Raychaudhuri3, 1Sacramento VA Medical Center/ UC Davis School of Medicine, Mather, CA, 2UC Davis School of Medicine/VA Sacramento Medical Center, Mather, CA, 3VA Sacramento Medical Center, Mather, CA
Association Between Human Leukocyte Antigen and Killer-Cell Immunoglobulin-Like Receptor Gene Variants and Type II Psoriasis and Dactylitis in Psoriatic Arthritis
Vinod Chandran1, Fawnda Pellett1, Arane Thavaneswaran1, Remy Pollock1, Renise Ayearst1 and Dafna D. Gladman2, 1Toronto Western Hospital and University of Toronto, Toronto, ON, 2Toronto Western Hospital, University of Toronto, Toronto, ON
Investigating the Association Between Endoplasmic Reticulum Aminopeptidase 1 Gene Variants and Psoriatic Arthritis
Vinod Chandran1, Fawnda Pellett2, Remy Pollock1, Al Amin P. Rahman3 and Dafna D. Gladman1, 1Toronto Western Hospital, University of Toronto, Toronto, ON, 2Toronto Western Hospital and University of Toronto, Toronto, ON, 3Memorial University, St Johns, NE
The Association Between Human Leukocyte Antigen and Killer-Cell Immunoglobulin-Like Receptor Gene Variants and the Development of Arthritis Mutilans in Patients with Psoriatic Arthritis
Vinod Chandran, Arane Thavaneswaran, Fawnda Pellett and Dafna D. Gladman, Toronto Western Hospital, University of Toronto, Toronto, ON
The Association Between Human Leukocyte Antigen and Killer-Cell Immunoglobulin-Like Receptor Gene Variants and the Development of Axial Arthritis Among Patients with Psoriatic Arthritis
Vinod Chandran, Arane Thavaneswaran, Fawnda Pellett and Dafna D. Gladman, Toronto Western Hospital, University of Toronto, Toronto, ON
Family Based Association Study Confirms Human Leukocyte Antigen Allele Associations with Psoriatic Arthritis
Vinod Chandran1, Fawnda Pellett1, Proton Rahman2 and Dafna D. Gladman1, 1Toronto Western Hospital, University of Toronto, Toronto, ON, 2St. Claires Mercy Hospital, St. Johns, NF
Proteomic Profiling of Synovial Fluid for the Identification of Psoriatic Arthritis Soluble Biomarkers
Daniel Cretu1, Dafna D. Gladman2, Fawnda Pellett3, Eleftherios Diamandis1 and Vinod Chandran3, 1Mount Sinai Hospital, Toronto, ON, 2Toronto Western Hospital, University of Toronto, Toronto, ON, 3Toronto Western Hospital and University of Toronto, Toronto, ON
Association of ERAP1, IL12B and IL23R Gene Polymorphisms with Subphenotypes of Psoriatic Arthritis
Deepak Jadon1, William Tillett1, Dinny Wallis1, Charlotte Cavill2, Anna Dixon2, Nicola Waldron1, Eleanor Korendowych1, Anne Barton3 and Neil J. McHugh1, 1Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, 2Bath Institute for Rheumatic Disease, Bath, United Kingdom, 3University of Manchester, Manchester, United Kingdom
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