Genomics, Proteomics, and Genetics

Session Type: ACR Abstract Submissions
Tuesday, November 8, 2011: 9:00 AM-6:00 PM
Hall F2 - Poster Hall (McCormick Place West)
Papers:
Proteomic Profiling Following Immunoaffinity Capture of HDL Identifies Association of Acute Phase Proteins and Complement Factors with Pro-Inflammatory HDL in Rheumatoid Arthritis
Christina Charles-Schoeman1, Yunan Miao2, Junji Watanabe3, Yuen Yin Lee4, George Katselis2, Terry D. Lee2 and Srinivasa T. Reddy3, 1UCLA David Geffen School of Medicine, Los Angeles, CA, 2Beckman Research Institute of the City of Hope, Duarte, CA, 3UCLA, Los Angeles, 4UCLA, Los Angeles, CA
Association Between Interferon Alpha Gene Expression and Disease Characteristics in Systemic Lupus Erythematosus
Michelle Petri1, Hong Fang1, Wenzheng Hu1, Jadwiga Bienkowska2, Norm Allaire2, John Carulli2 and Matthew D. Linnik3, 1Johns Hopkins University School of Medicine, Baltimore, MD, 2Biogen Idec Inc., Cambridge, MA, 3Biogen Idec Inc., Solana Beach, CA
Association Between Plasma Cell Gene Signature and Disease Characteristics in Systemic Lupus Erythematosus
Michelle Petri1, Hong Fang1, Jie Xu1, Wenzheng Hu1, Ehtisham Akhter1, Jadwiga Bienkowska2, Norm Allaire2, John Carulli2, Laurence S. Magder3 and Matthew D. Linnik4, 1Johns Hopkins University School of Medicine, Baltimore, MD, 2Biogen Idec Inc., Cambridge, MA, 3University of Maryland, Baltimore, MD, 4Biogen Idec Inc., Solana Beach, CA
Narrowing the Protein Tyrosine Phospahatse-22 Locus in Mice with Cartilage Proteoglycan-Induced Arthritis Explores Disease-Promoting and Disease-Suppressive Sub-Loci Neutralizing Their In Vivo Arthritis Susceptibility and Severity
Timea Besenyei1, Andras Kadar1, Beata Tryniszewska1, Vyacheslav A. Adarichev2, Katalin Mikecz1 and Tibor T. Glant1, 1Rush University Medical Center, Chicago, IL, 2Albert Einstein College of Medicine, Bronx, NY
Identification of microRNA-31 as a novel regulator contributing to impaired IL-2 production in T cells from patients with systemic lupus Erythematosus
Wei Fan1, Yuanjia Tang1, Bo Qu1, Huijuan Cui1, Xinfang Huang1, Brandon W. Higgs2, Yihong Yao2, Bahija Jallal2 and Nan Shen1, 1Shanghai Ren Ji Hospital, Shanghai, China, 2MedImmune, Gaithersburg, MD
The Passenger Strand of MicroRNA-34a Is Epigenetically Silenced in Rheumatoid Arthritis Synovial Fibroblasts and Mediates Apoptosis Resistance Via Failure of XIAP (X-linked inhibitor of apoptosis protein) Inhibition
Fabienne Niederer1, Caroline Ospelt1, Joanna Stanczyk2, Michelle Trenkmann2, Emmanuel Karouzakis2, Meike Dahlhaus2, Beat A. Michel2, Christoph Kolling3, Renate E. Gay2, Steffen Gay2, Astrid Juengel2 and Diego Kyburz2, 1Center of Experimental Rheumatology, University Hospital Zurich, Zurich, Switzerland, 2Center of Exp. Rheumatology, Zurich, Switzerland, 3Schultess Clinic, Zurich, Switzerland
Adoptive Transfer of Induced-Regulatory T Cells Effectively Attenuates Murine Airway Allergic Inflammation
Qin Lan1, Wei Xu2, Julie Wang1, Hui-Ming Fan3, Bernhard Ryffel4, Wei Shi2 and Song G. Zheng5, 1University of Southern California, Los Angeles, CA, 2The Saban Rrsearch Institute of Children's Hospital Los Angeles, 3Shanghai East Hospital, Tonji University, Shanghai, China, 4University and CNRS, 3b rue de la Ferollerie, F-45071 Orleans, France, 5USC Keck School of Medicine, Los Angeles, CA
Correlations Between S100 Gene Expression Levels and the Local and Systemic Inflammatory Markers (matrix metalloproteinase-3, MMP3; erythrocyte sedimentation rate, ESR) in Rheumatoid Arthritis Patients
Hooi-Ming Lee1, Hidehiko Sugino1, Chieko Aoki2, Miho Murakami2, Takaji Matsutani2, Takahiro Ochi3 and Norihiro Nishimoto2, 1Osaka University, Suita, Japan, 2Wakayama Medical University, Ibaraki, Japan, 3Osaka Police Hospital, Osaka, Japan
Proteomic Characterization of Plasma Microparticles in Autoimmune Diseases
Christoffer T. Nielsen1, Ole Østergaard1, Line V. Iversen1, Søren Jacobsen2 and Niels H.H. Heegaard1, 1Statens Serum Institut, Copenhagen S, Denmark, 2Rigshospitalet - 4242, Copenhagen, Denmark
Feasibility of a Molecular Diagnosis of Arthritis Based on the Identification of Specific Transcriptomic Profiles in Knee Synovial Biopsies
Isabelle Focant1, Daniel Hernandez-Lobato2, Julie Ducreux1, Patrick Durez1, Adrien Nzeusseu Toukap1, Dirk Elewaut3, Frédéric A. Houssiau1, Pierre Dupont2 and Bernard Lauwerys1, 1Université catholique de Louvain, Brussels, Belgium, 2Université catholique de Louvain, Louvain-La-Neuve, Belgium, 3Gent University Hospital, Ghent, Belgium
Selective Inhibition of Epigenetic Factors Provide Potential New Tools for Arthritis Therapy
Timea Besenyei, Júlia Kurkó, Katalin Mikecz, Tibor T. Glant and Tibor A. Rauch, Rush University Medical Center, Chicago, IL
Genome-Wide DNA Methylation Profiling Studies of Lymphocytes in Arthritic Mice
Tamas Kobezda1, Katalin Olasz2, Katalin Mikecz1, Tibor T. Glant1 and Tibor A. Rauch1, 1Rush University Medical Center, Chicago, IL, 2Pecs, Hungary
The De Novo Revision of TCRα but Not TCRβ Is Responsible for the Generation of Autoantibody-Inducing CD4+ (aiCD4+) T Cell That Causes Systemic Autoimmunity
Kenichi Uto1, Ken Tsumiyama1 and Shunichi Shiozawa2, 1Kobe University Graduate School of Health Science, Kobe, Japan, 2Kobe University Graduate School of Health Science and Medicine/ The Center for Rheumatic Diseases, Kobe University Hospital, Kobe, Japan
The Transcriptomic Analysis From PBMC Is a Powerful Approach to Identify Specific Signatures Able to Predict Responses for Each TNFalpha Blocking Agent
Romain Normand1, Olivier Vittecoq2, Martine Hiron1, Céline Derambure1, Xavier Le Loët2 and Thierry Lequerré2, 1Inserm 905 & Institute for Biomedical Research, University of Rouen, Rouen, France, 2Department of Rheumatology, Rouen University Hospital & Inserm 905, Institute for Biomedical Research, University of Rouen, Rouen, France
Identification of A SET of 8 Proteins ABLE to PREDICT the RESPONSE to Methotrexate/Etanercept In Rheumatoid Arthritis PATIENTS
Antoine Obry1, Pascal Cosette2, Philippe Chan Tchi Tsong3, Jéremy Siemowski4, Paul Morel4, Olivier Boyer1, Patrice Fardellone5, René-Marc Flipo6, Christian Marcelli7, Xavier Le Loët8, Thierry Lequerré8 and Olivier Vittecoq8, 1Inserm 905 & Institute for Biomedical Research, University of Rouen, Rouen, France, 2UMR 6270 CNRS, Plate-Forme d'Analyse protéomique de l'IFRMP23, Faculté des Sciences, University of Rouen, Rouen, France, 3Inserm 982, Plate-Forme d'Analyse Protéomique de l'IFRMP23, Faculté des Sciences, University of Rouen, Rouen, France, 4UMR 6270 CNRS, Faculté des Sciences, University of Rouen, France, 5Rheumatology Department, Amiens University Hospital, Amiens, France, 6Rheumatology Department, Lille University Hospital, Lille, France, 7Rheumatology Department, Caen University Hospital, 8Department of Rheumatology, Rouen University Hospital & Inserm 905, Institute for Biomedical Research, University of Rouen, Rouen, France
Salivary Proteomics and Churg-Strauss Syndrome: A Phase IIa Case-Control Study Aimed At Identifying Novel Diagnostic Disease Biomarkers
Chiara Baldini, Daniela Martini, Sara Grossi, Nicoletta Luciano, Francesco Ferro and Stefano Bombardieri, Rheumatology Unit, Pisa, Italy
BAFF and TACI Gene Expression Are Increased in Untreated Very Early Rheumatoid Arthritis Patients
Rita A. Moura1, Helena Canhão2, Joaquim Polido-Pereira2, Ana M. Rodrigues2, Márcio Navalho3, Ana F. Mourão4, Carlos M. Rosa5, Catarina Resende5, Raquel Campanilho-Marques2, João Madruga Dias2, João R. da Silva5, Mário Bexiga5, José A. Pereira da Silva5, Luis Graca6 and João E. Fonseca7, 1Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal, 2Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa and Rheumatology Department, Centro Hospitalar de Lisboa Norte, EPE, Hospital de Santa Maria, Lisbon, Portugal, 3Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa and Radiology Department, Hospital da Luz, Lisbon, Portugal, 4Rheumatology Research Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa and Rheumatology Department, Centro Hospitalar de Lisboa Ocidental, EPE, Hospital Egas Moniz, Lisbon, Portugal, 5Rheumatology Department, Centro Hospitalar de Lisboa Norte, EPE, Hospital de Santa Maria, Lisbon, Portugal, 6Cellular Immunology Unit, Instituto de Medicina Molecular, Faculdade de Medicina da Universidade de Lisboa, Lisbon, Portugal, 7Lisbon Academic Medical Center, on behalf of Rheumatic Diseases Portuguese Register (Reuma.pt), Lisbon, Portugal
SLC2A9 Gene Expression Is Associated with a Haplotype Tagging Polymorphism
Philip L. Riches, Samuel Gray, Omar Albagha and Stuart H. Ralston, University of Edinburgh, Edinburgh, United Kingdom
Elevated Expression of MMP9 in Plasma of Patients with Symptomatic Knee Osteoarthritic: Correlation with Disease Severity and Progression
Mukundan Attur1, Jeffrey D. Greenberg2, John Todd3, Quynh Ann Lu3, Renita Ramirez3, Cheongeun Oh4, Jonathan Samuels1, Svetlana Krasnokutsky5 and Steven B. Abramson1, 1NYU Hospital for Joint Diseases, New York, NY, 2New York University School of Medicine, New York, NY, 3Singulex, Alameda, California, Alameda, CA, 4New York University, New York, NY, 5NYU Hospital for Joint Disease, New York, NY
MicroRNA Expression in Vault Particles
Anne Rowzee1, Mayank Tandon1, Alessia Gallo1, John Routsias2, Athanasios G. Tzioufas3 and Ilias Alevizos4, 1NIDCR, Bethesda, MD, 2National University of Athens, Greece, 3School of Medicine, National University of Athens, Greece, Athens, Greece, 4NIDCR/ NIH #10 1N110, Bethesda, MD
Regulation of Apoptosis and Matrix Metalloproteinase Expression by Small Ubiquitin Related Modifier-2/3 in Rheumatoid Arthritis Fibroblast-Like Synoviocytes
Svetlana Frank1, Simon Strietholt1, Christine Seyfert2, Marvin A. Peters3, Thomas Pauly4, George Kollias5 and Thomas Pap6, 1Institute of Experimental Musculoskeletal Medicine, University of Muenster, Muenster, Germany, 2Department of Orthopaedic Surgery, Zeisigwaldkliniken, Chemnitz, Germany, 3Kerckhoff- Klinik GmbH, Justus-Liebig-University Gießen, Bad Nauheim, Gießen, Germany, 4Department of Nephrology and Rheumatology, Heinrich-Heine University, Meerbusch, Germany, 5Biomedical Sciences Research Center 'Alexander Fleming', Vari, Greece, 6University Hospital Münster, Münster, Germany
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