Rheumatoid Arthritis - Human Etiology and Pathogenesis

Session Type: ACR Abstract Submissions
Tuesday, November 8, 2011: 9:00 AM-6:00 PM
Hall F2 - Poster Hall (McCormick Place West)
Papers:
Polymorphisms in N-Acetyltransferase 2 Impact Rheumatoid Arthritis Risk Due to Cigarette Smoking in African Americans
Marshall Davis1, Tricia LeVan1, Karen Gould1, Fang Yu1, Geoffrey M. Thiele1, Kimberly Bynote1, Larry W. Moreland2, Doyt L. Conn3, Edwin A. Smith4, Leigh F. Callahan5, Beth L. Jonas6, Richard Brasington7, S. Louis Bridges Jr.8 and Ted R. Mikuls1, 1Univ of Nebraska Med Ctr, Omaha, NE, 2University of Pittsburgh, Pittsburgh, PA, 3Emory Univ School of Medicine, Atlanta, GA, 4Med Univ of South Carolina, Charleston, SC, 5University of North Carolina, Chapel Hill, NC, 6University of North Carolina at Chapel Hill, Chapel Hill, NC, 7Washington Univ School of Med, St. Louis, MO, 8Marguerite Jones Harbert-Gene V. Ball, MD Professor of Medicine, and Director, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL
Integrative Analyses Demonstrate That Rheumatoid Arthritis Risk Loci Impact Genes with CD4+ Effector Memory T-Cell Function
Xinli Hu1, Hyun Kim1, Eli A. Stahl1, Robert M. Plenge1, Mark Daly2 and Soumya Raychaudhuri1, 1Brigham and Women's Hospital, Boston, MA, 2Massachusetts General Hospital, Boston, MA
The Hierarchy of HLA-DRB1 Shared Epitope Risk Genotypes Associated with RA in African-Americans Differs From That in Europeans
Altan F. Ahmed1, Laura B. Hughes1, Doyt L. Conn2, Beth L. Jonas3, Leigh F. Callahan4, Edwin A. Smith5, Richard D. Brasington6, Larry W. Moreland7, S. Louis Bridges Jr.1 and Richard J. Reynolds1, 1University of Alabama at Birmingham, Birmingham, AL, 2Emory Univ School of Medicine, Atlanta, GA, 3University of North Carolina at Chapel Hill, Chapel Hill, NC, 4University of North Carolina, Chapel Hill, NC, 5Med Univ of South Carolina, Charleston, SC, 6Washington Univ School of Med, St. Louis, MO, 7University of Pittsburgh, Pittsburgh, PA
Apolipoprotein M Polymorphism Is a Novel Risk Factor for Dyslipidemia in Rheumatoid Arthritis: A Possible Link Between Disease Susceptibility and dyslipidemia  
Yune-Jung Park1, Jung-Hwa Lee1, Hosung Yoon2, Daejun Kim1, Chul-Soo Cho3 and Wan-Uk Kim1, 1The Catholic University of Korea, St. Vincent's Hospital, Suwon, South Korea, 2The Catholic University, Incheon, South Korea, 3The Catholic University of Korea, Seoul
Increased Frequency of Complement C4B Deficiency in Rheumatoid Arthritis (RA): Interaction with the Shared Epitope (SE)
William F. C. Rigby1, Y.L. Wu2, Moe T. Zan3, Bi Zhou2, Sanna Rosengren4, Cheryl Carlson5, Whitney Hilton5, Jonathan D. Jones6 and Chack-Yung Yu7, 1Dartmouth-Hitchcock Med Ctr, Lebanon, NH, 2Nationwide Children's Hospital The Ohio State University, Columbus, OH, Columbus, OH, 3Dartmouth-Hitchcock Clinic, Manchester, NH, 4UCSD School of Medicine, La Jolla, CA, 5Dartmouth Hitchcock Med Ctr, Lebanon, NH, 6Dartmouth-Hitchcock Medical Center, Lebanon, NH, 77Center for Molecular and Human Genetics, The Research Institute at Nationwide Children's Hospital and The Ohio State University, Columbus, OH
The STAT4 rs7574865 Polymorphism Is Associated with Differences in Disease Activity and Disability in Patients Wirh Early Arthritis
Ana M. Ortiz1, Amalia Lamana1, Alejandro Balsa2, Blanca Rueda3, Laura Nuño2, Maria Eugenia Miranda-Carus2, María F. González-Escribano4, Miguel A. López-Nebot5, Dora Pascual-Salcedo2, Javier Martin6 and Isidoro González-Alvaro1, 1Hospital Universitario de La Princesa. IIS Princesa, Madrid, Spain, 2Hospital La Paz. IdiPaz, Madrid, Spain, 3Facultad de Ciencias de la Salud. Universidad de Granada, Granada, Spain, 4Hospital Universitario Virgen del Rocío, Sevilla, Spain, 5Hospital Universitario Virgen de las Nieves, Granada, Spain, 6Instituto de Parasitologia y Biomedicina Lopez-Neyra (CSIC), Granada, Spain
The Complexity of Anti-CCP Positive Rheumatoid Arthritis, in the Context of Gene-Environment Associations
Karin Lundberg, Camilla Bengtsson, Lena Israelsson, Nastya Kharlamova, Iskra Pollak-Dorocic, Rikard Holmdahl, Leonid Padyukov, Vivianne Malmström, Lars Alfredsson and Lars Klareskog, Karolinska Institutet, Stockholm, Sweden
Genome-Wide Association Study and Comparison of Risk Alleles for Rheumatoid Arthritis in An Isolated Dutch Population
Joanne Nitiham1, Kimberly E. Taylor1, Yurii S. Aulchenko2, Ben Oostra2, Robert M. Plenge3, Tom W.J. Huizinga4, Peter K. Gregersen5, Cornelia M. van Duijn2 and Lindsey A. Criswell1, 1University of California, San Francisco, San Francisco, CA, 2Erasmus Medical Center, Rotterdam, Netherlands, 3Brigham and Women's Hospital, Boston, MA, 4Leiden University Medical Center, Leiden, Netherlands, 5Feinstein Institute Medical Reschearch, Manhasset, NY
Vitamin D Receptor Polymorphism rs2228570 (Fokl) in North American Natives with Rheumatoid Arthritis and Their Unaffected First Degree Relatives
Carol A. Hitchon1, Ye Sun2, David B. Robinson1, Christine A. Peschken1, Charles N. Bernstein1, Katherine A. Siminovitch2 and Hani S. El-Gabalawy1, 1University of Manitoba, Winnipeg, MB, 2Mount Sinai Hospital, Toronto, ON
The I50V IL4R SNP Is Associated with Increased Th17 Cell Frequency and Activity in Autoimmune Arthritis
Jan Leipe1, Iryna Prots2, Markus A. Schramm1, Alla Skapenko1 and Hendrik Schulze-Koops1, 1Division of Rheumatology and Clinical Immunology, Med. Poliklinik, University of Munich, Munich, Germany, 2Junior Research Group III, Nikolaus-Fiebiger Center for Molecular Medicine, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen
Fine-Mapping of Autoimmune Susceptibility Loci Using Immunochip Identifies Novel Susceptibility Loci for Psoriatic Arthritis
John Bowes1, Pauline Ho2, Eleanor Korendowych3, Neil J. McHugh3, Helena Marzo-Ortega4, Jonathon Packham5, Ian N. Bruce1 and Anne Barton1, 1Arthritis Research UK Epidemiology Unit, Manchester Academic Health Science Centre, The University of Manchester, Manchester, United Kingdom, 2Arthritis Research UK, Manchester, United Kingdom, 3Royal National Hospital for Rheumatic Diseases, Bath, United Kingdom, 4University of Leeds, Leeds, United Kingdom, 5Haywood Hospital, Stoke on Trent, United Kingdom
The Potential Role of PTPRD Gene Copy Number Variation in Susceptibility to Rheumatoid Arthritis
Seung Cheol Shim, Donghyuk Sheen, Mi-Kyoung Lim, Jiyoung Kim, Soyoung Lee and Sangkwang Lee, Eulji University Hospital, Daejeon, South Korea
Exposure to Environmental Tobacco Smoke and the Risk of Rheumatoid Arthritis Among Nonsmoking Women
So-Young Bang, Hye-Soon Lee, Jae Hoon Kim, Joo-Hyun Lee, Jin Ju Kim, Young Bin Joo and Sang-Cheol Bae, Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea
Smoking and Oxidative Stress Interaction Is Associated with Rheumatoid Arthritis Risk. A Case – Control Study
Victoria Navarro Compán, Enrique Melguizo Madrid, Blanca Hernández Cruz, Christian Leyva Prado, Teresa Arrobas Velilla, Federico Navarro Sarabia and Concepción González Rodríguez, Hospital Universitario Virgen Macarena, Sevilla, Spain
Smoking and Periodontal Status Are Associated with ACPA Fine Specificity and Levels of Inflammatory Cytokines in Rheumatoid Arthritis: The ARIC Study
Reuven Bromberg1, Jeremy Sokolove1, Lauren J. Lahey1, Alvaro Alonso2, Mark H. Wener3, Vivian H. Gersuk4, Jane Hoyt Buckner4, James D. Beck5, Bryan S. Michalowicz6, Aaron A. Folsom2, William Robinson7 and Jerry A. Molitor8, 1Stanford University, Palo Alto, CA, 2Minneapolis, 3University of Washington, Seattle, WA, 4Benaroya Research Institute, Seattle, WA, 5Chapel Hill, NC, 6Minneapolis, MN, 7Stanford Univ School of Med, Stanford, CA, 8Univ of MN MMC108, Minneapolis, MN
Relationships Between Smoking, HLA-DRB1 Risk Alleles and the Fine Specificity of Anti-Citrullinated Peptide Antibodies in Korean Patients with Rheumatoid Arthritis
Benjamin A. Fisher1, So-Young Bang2, Hye-Soon Lee2, Joo-Hyun Lee2, Muslima Chowdhury3, Peter J. Charles4, Patrick Venables5 and Sang-Cheol Bae6, 1Kennedy Institute of Rheumatology, Imperial College London, London, United Kingdom, 2Hanyang University Hospital for Rheumatic Diseases, Seoul, South Korea, 3Imperial College London, London, United Kingdom, 4Kennedy Institute of Rheumatology, Imperial College, London, United Kingdom, London, England, 5Kennedy Institute, Imperial College London, London, United Kingdom, 6Hanyang University Hospital for Rheumatic Diseases, Clinical Research Center for Rheumatoid Arthritis (CRCRA), Seoul, South Korea
Association of Particulate Air Pollution Exposure with Anti-Citrullinated Protein Antibody  Elevation in Rheumatoid Arthritis Patients
Gary A. Kunkel1, Ryan L. Ragle1, Daniel O. Clegg1, Ted R. Mikuls2 and Grant W. Cannon1, 1Salt Lake City VA and University of Utah, Salt Lake City, UT, 2Omaha VA and University of Nebraska, Omaha, NE
Childhood Residential Pesticides and Other Environmental Exposures in Relation to Rheumatoid Arthritis (RA) in Adulthood
Christine G. Parks, Aimee D'Aloisio, Lisa DeRoo and Dale Sandler, NIH/NIEHS, Research Triangle Park, NC
Periodontal Disease Is Associated with Increased Risk of Incident Rheumatoid Arthritis in Never-Smokers: Results From the First National Health and Nutrition Examination Survey and Its Epidemiologic Follow-up Study
Ryan T. Demmer1, David R. Jacobs Jr.2, Bryan S. Michalowicz2 and Jerry A. Molitor3, 1New York, 2Minneapolis, MN, 3Univ of MN MMC108, Minneapolis, MN
Prevalence of Periodontitis Is High in Rheumatoid Arthritis Patients and Correlated to Disease Activity
Menke J. de Smit, Johanna Westra, Arjan Vissink, Berber Doornbos-van der Meer, Pieter A. Roelofs, Elisabeth Brouwer and Arie Jan van Winkelhoff, University Medical Center Groningen, Groningen, Netherlands
Lung Changes Detected by High Resolution Tomography Are Present in ACPA Positive RA Patients Already At Disease Onset
Gudrun Reynisdottir1, Sven Nyren2, Anders Harju1, Magnus Skold3, Anders Eklund1, Marianne Engström1, Johan Grunewald3, Lars Klareskog4 and Anca Irinel Catrina5, 1Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, Stockholm, Sweden, 2Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, Stockholm, Sweden, 3Respiratory Medicine Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, Stockholm, Sweden, 4Karolinska Institutet, Stockholm, Sweden, 5D2:01, Stockholm, Sweden
Investigating the Cellular Composition of Lymph Nodes in Preclinical and Early Inflammatory Arthritis: A Feasibility Study
Lisa G.M. van Baarsen1, Maria J. H. de Hair1, Tamara H. Ramwadhdoebe1, Marleen G. H. van de Sande1, IJsbrand A.J. Zijlstra2, Mario Maas2, Danielle M. Gerlag1 and PP. Tak1, 1Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands, 2Department of Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
Type 1 Interferon Signature Predicts Development of Rheumatoid Arthritis
Joyce Lubbers1, Mikael Brink2, Lotte A. van de Stadt3, Saskia Vosslamber1, John G. Wesseling1, Dirkjan van Schaardenburg3, Solbritt M. Rantapaa-Dahlqvist2 and Cornelis L. Verweij1, 1VU University Medical Center, Amsterdam, Netherlands, 2Umeå University, Umea, Sweden, 3Jan van Breemen Research Institute / Reade, Amsterdam, Netherlands
Identification of Shared Citrullinated Potentially Immunological Targets in the Lungs and Joints of Patients with Rheumatoid Arthritis
Jimmy Ytterberg1, Gudrun Reynisdottir1, Elena Ossipova1, Aase Haj Hensvold2, Anders Eklund3, Magnus Skold3, Johan Grunewald3, Karin Lundberg4, Vivianne Malmström4, Per Johan Jakobsson5, Roman Zubarev4, Lars Klareskog4 and Anca Irinel Catrina1, 1Rheumatology Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, Stockholm, Sweden, 2Rheumatology unit, 171 76 Stockholm, Sweden, 3Respiratory Medicine Unit, Department of Medicine, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden, Stockholm, Sweden, 4Karolinska Institutet, Stockholm, Sweden, 5Rheumatology Unit, Karolinska Institutet; Karolinska University hospital, Stockholm, Sweden
A Disease-Modifying Role for Mucosal IgA Antibodies to Citrullinated Antigens?
Anna Svärd, Linköping University, Falun, Sweden, Alf Kastbom, Linköping University, Linköping, Sweden, Yngve Sommarin, Euro-Diagnostica AB, Malmö, Sweden and Thomas Skogh, Linkoping University, Linkoping, Sweden
The ACPA Recognition Profile and Sub-Grouping of APCA Positive RA Patients.
Annemiek Willemze, Stefan Böhringer, Rachel Knevel, E.W.Nivine Levarht, Gerrie Stoeken-Rijsbergen, Jeanine J. Houwing-Duistermaat, Annette H.M. van der Helm-van Mil, Tom W.J. Huizinga, René E.M. Toes and Leendert A. Trouw, Leiden University Medical Center, Leiden, Netherlands
Total Protein, Citrullination and Autoantibodies Are Elevated in Lungs of Patients with Established Rheumatoid Arthritis Compared to Controls: Pilot Study Results
Van Willis1, Mark Parish1, Lezlie A. Derber2, M. Kristen Demoruelle3, Jason R. Kolfenbach4, Chris Striebich3, Peter Sachs3, David Lynch5, Russell Bowler5, Kevin K. Brown6, V. Michael Holers4 and Kevin D. Deane3, 1University of Colorado Anschutz Medical Campus, Aurora, CO, 2University of Colorado AMC, Aurora, CO, 3University of Colorado School of Medicine, Aurora, CO, 4Univ of Colorado School of Med, Aurora, CO, 5National Jewish Health, Denver, CO, 6National Jewish Hospital, Denver, CO
A Serological Proteome Approach for Screening of Autoantigens From Korean Rheumatoid Arthritis Patients
Sung-Hoon Park1, Ji Hun Kim1, Seong-Kyu Kim2, Jung-Yoon Choe3, Sang-Hyon Kim4, Yong-Hak Kim5, Yeonkyung Park5 and Mina Choi5, 1Arthritis and Autoimmunity Research Center, Catholic University of Daegu School of Medicine, Daegu, South Korea, 2Arthritis and Autoimmunity Research Center, Catholic University of Daegu School of Medicine, Daegue, South Korea, 3Arthritis and Autoimmunity Research Center, Catholic university of Daegu, School of mediine, Daegu, 4Dongsan Medical Center, Keimyung University, Daegu, South Korea, 5Catholic univeristy of Daegu, School of Medicine, Daegu, South Korea
Could Presence of Antibodies to Citrullinated Proteins Be More Strongly Associated to Bone- Than Cartilage Destruction?- Results From a 10-Year Prospective Study
Silje Watterdal Syversen1, Pernille Bøyesen2, Guro Løvik Goll1, D. Van Der Heijde3 and Tore K. Kvien2, 1Oslo, Norway, 2Diakonhjemmet Hospital, Oslo, Norway, 3Leiden University Medical Center, Leiden, Netherlands
Rheumatoid Arthritis Patients Have Anti-Homocitrullinated Fibrinogen Antibodies
Mathias Scinocca1, David A. Bell1, Janet Pope2, Ewa Cairns1 and Lillian J. Barra1, 1Schulich School of Medicine and Dentistry, London, ON, 2Univ of Western Ontario, London, ON
Heterogeneity in the Memory B Cell Compartment in the Bone Marrow in Human Rheumatoid Arthritis
Arumugam Palanichamy, Christopher A. Cistrone, Jennifer Hossler, Teresa Owen and Jennifer H. Anolik, University of Rochester, Rochester, NY
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